Current status and perspectives of patient-derived xenograft models in cancer research

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

(2017) Aviram Mizrachi et al.   Nature Communications

Multisynergistic Platform for Tumor Therapy by Mild Microwave Irradiation-Activated Chemotherapy and Enhanced Ablation

(2016) Dan Long et al.   ACS Nano

Diffuse large B-cell lymphoma patient-derived xenograft models capture the molecular and biological heterogeneity of the disease

(2016) B. Chapuy et al.   BLOOD

Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation

(2016) Giuliana Cavalloni et al.   BMC CANCER

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors

(2016) Xiumei Huang et al.   CANCER CELL

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors

(2016) Shom Goel et al.   CANCER CELL

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

(2016) Michaël Cerezo et al.   CANCER CELL

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia

(2016) Silvia Nucera et al.   CANCER CELL

N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells

(2016) John K. Lee et al.   CANCER CELL

Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

(2016) Jungoh Ham et al.   CANCER CELL

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

(2016) Elizabeth C. Townsend et al.   CANCER CELL

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma

(2016) Wei Wei et al.   CANCER CELL

High-throughput Phenotyping of Lung Cancer Somatic Mutations

(2016) Alice H. Berger et al.   CANCER CELL

Antitumor effect of FGFR inhibitors on a novel cholangiocarcinoma patient derived xenograft mouse model endogenously expressing an FGFR2-CCDC6 fusion protein

(2016) Yu Wang et al.   CANCER LETTERS

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells

(2016) Michael Boice et al.   CELL

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

Cetuximab Inhibits T790M-Mediated Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in a Lung Adenocarcinoma Patient-Derived Xenograft Mouse Model

(2016) Petra Martin et al.   Clinical Lung Cancer

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Histologic and molecular analysis of patient derived xenografts of high-grade serous ovarian carcinoma

(2016) Ruifen Dong et al.   Journal of Hematology & Oncology

Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

(2016) Zhiwu Jiang et al.   Journal of Hematology & Oncology

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

(2016) Petra ter Brugge et al.   JNCI-Journal of the National Cancer Institute

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

(2016) Raymond G. Fox et al.   NATURE

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

Melanoma addiction to the long non-coding RNA SAMMSON

(2016) Eleonora Leucci et al.   NATURE

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

(2016) Eirini P Papapetrou   NATURE MEDICINE

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

Patient-Derived Xenograft: An Adjuvant Technology for the Treatment of Metastatic Disease

(2016) Guilhem Bousquet et al.   PATHOBIOLOGY

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model

(2016) Mako Yamamoto et al.   PLoS One

A U.S. "Cancer Moonshot" to accelerate cancer research

(2016) D. S. Singer et al.   SCIENCE

Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma

(2016) Juli R. Bagó et al.   Nature Communications

Gene and microRNA modulation upon trabectedin treatment in a human intrahepatic cholangiocarcinoma paired patient derived xenograft and cell line

(2016) Caterina Peraldo Neia et al.   Oncotarget

Tumor Take Rate Optimization for Colorectal Carcinoma Patient-Derived Xenograft Models

(2016) Michael Gock et al.   Biomed Research International

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

(2016) Petra ter Brugge et al.   JNCI-Journal of the National Cancer Institute

Patient-derived xenograft mouse models of pseudomyxoma peritonei recapitulate the human inflammatory tumor microenvironment

(2016) Murali R. Kuracha et al.   Cancer Medicine

Anti-Tumoral Effects of Anti-Progestins in a Patient-Derived Breast Cancer Xenograft Model

(2016) Nathalie Esber et al.   Hormones & Cancer

Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor

(2016) Xuemei Jiang et al.   Frontiers in Immunology

Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers

(2016) K. B. Skowron et al.   Scientific Reports

BRCA1 and BRCA2 mutations sensitize to chemotherapy in patient-derived pancreatic cancer xenografts

(2015) I Lohse et al.   BRITISH JOURNAL OF CANCER

Five critical elements to ensure the precision medicine

(2015) Chengshui Chen et al.   CANCER AND METASTASIS REVIEWS

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death

(2015) Lei Wang et al.   CANCER CELL

Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes

(2015) Ana Herrero et al.   CANCER CELL

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

(2015) Colin A. Flaveny et al.   CANCER CELL

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia

(2015) Shuo-Chieh Wu et al.   CANCER CELL

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma

(2015) Maria Romina Girotti et al.   CANCER CELL

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models

(2015) Helen Y. Zou et al.   CANCER CELL

CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia

(2015) Diana Passaro et al.   CANCER CELL

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

(2015) Lauren A. Pitt et al.   CANCER CELL

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

(2015) Bingshe Han et al.   CANCER CELL

Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery

(2015) S Yano et al.   CANCER GENE THERAPY

The combinational therapy of trastuzumab and cetuximab inhibits tumor growth in a patient-derived tumor xenograft model of gastric cancer

(2015) C. J. Wang et al.   Clinical & Translational Oncology

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

(2015) E. M. Lee et al.   HAEMATOLOGICA

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells

(2015) Y. Xiao et al.   HAEMATOLOGICA

Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments

(2015) Wei Ye et al.   Journal of Hematology & Oncology

Inhibiting MDM2-p53 Interaction Suppresses Tumor Growth in Patient-Derived Non–Small Cell Lung Cancer Xenograft Models

(2015) Josephine Hai et al.   Journal of Thoracic Oncology

Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer

(2015) Jun Lu et al.   Journal of Translational Medicine

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice

(2015) J Etchin et al.   LEUKEMIA

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

(2015) Elaine E. Storm et al.   NATURE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

(2015) J J Morton et al.   ONCOGENE

The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells

(2015) Lotte M.E. Berghauser Pont et al.   PLoS One

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Patient-Derived Xenografts as a Model System for Radiation Research

(2015) Christopher D. Willey et al.   SEMINARS IN RADIATION ONCOLOGY

Concise Review: Humanized Models of Tumor Immunology in the 21st Century: Convergence of Cancer Research and Tissue Engineering

(2015) Boris Michael Holzapfel et al.   STEM CELLS

Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells

(2015) Keiki Sugimoto et al.   Scientific Reports

Biobanking of patient and patient-derived xenograft ovarian tumour tissue: efficient preservation with low and high fetal calf serum based methods

(2015) Nicolette G. Alkema et al.   Scientific Reports

Establishment and characterization of patient-derived tumor xenograft using gastroscopic biopsies in gastric cancer

(2015) Yan Zhu et al.   Scientific Reports

Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice

(2015) E. M. Lee et al.   HAEMATOLOGICA

ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells

(2015) Y. Xiao et al.   HAEMATOLOGICA

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

(2015) Estrelania S. Williams et al.   Jove-Journal of Visualized Experiments

Patient-Derived Gastric Carcinoma Xenograft Mouse Models Faithfully Represent Human Tumor Molecular Diversity

(2015) Tianwei Zhang et al.   PLoS One

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer

(2015) Zachary C. Dobbin et al.   Oncotarget

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia

(2014) Jeffery M. Klco et al.   CANCER CELL

CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

(2014) Sadhna R. Vora et al.   CANCER CELL

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

(2014) Erik Procko et al.   CELL

Successful Fluorescence-Guided Surgery on Human Colon Cancer Patient-Derived Orthotopic Xenograft Mouse Models Using a Fluorophore-Conjugated Anti-CEA Antibody and a Portable Imaging System

(2014) Yukihiko Hiroshima et al.   Journal of Laparoendoscopic & Advanced Surgical Techniques

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

(2014) Antonina V. Kurtova et al.   NATURE

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

(2014) Andriy Marusyk et al.   NATURE

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing

(2014) Andrea Pavía-Jiménez et al.   Nature Protocols

Circulating Tumor Cells as a Biomarker of Response to Treatment in Patient-Derived Xenograft Mouse Models of Pancreatic Adenocarcinoma

(2014) Robert J. Torphy et al.   PLoS One

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity

(2014) P. S. Adusumilli et al.   Science Translational Medicine

A Human ICAM-1 Antibody Isolated by a Function-First Approach Has Potent Macrophage-Dependent Antimyeloma Activity In Vivo

(2013) Niina Veitonmäki et al.   CANCER CELL

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties

(2013) Françoise Bono et al.   CANCER CELL

NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers

(2013) Wen Zhou et al.   CANCER CELL

Development and characterization of a colon PDX model that reproduces drug responsiveness and the mutation profiles of its original tumor

(2013) Hyang Sook Seol et al.   CANCER LETTERS

Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγnull(NSG) mice engrafted with human thymus and autologous haematopoietic stem cells

(2013) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model

(2013) Cristina A. Metildi et al.   JOURNAL OF SURGICAL ONCOLOGY

Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies

(2013) Xu-chao Zhang et al.   Journal of Translational Medicine

The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere

(2013) Jing Li et al.   Journal of Translational Medicine

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs

(2013) Liuqing Yang et al.   NATURE

Erlotinib Inhibits Growth of a Patient-Derived Chordoma Xenograft

(2013) I-Mei Siu et al.   PLoS One

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

(2012) Michael A. Milhollen et al.   CANCER CELL

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Engineering humanized mice for improved hematopoietic reconstitution

(2012) Adam C Drake et al.   Cellular & Molecular Immunology

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

(2012) C Allen et al.   GENE THERAPY

Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models

(2012) Xianhua Wu et al.   Journal of Translational Medicine

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

(2012) Anirudh Prahallad et al.   NATURE

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant

(2011) Hiroshi Sakamoto et al.   CANCER CELL

Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance

(2011) Rebekka Krumbach et al.   EUROPEAN JOURNAL OF CANCER

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Assessment of a Novel VEGF Targeted Agent Using Patient-Derived Tumor Tissue Xenograft Models of Colon Carcinoma with Lymphatic and Hepatic Metastases

(2011) Ketao Jin et al.   PLoS One

Establishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation

(2010) L de Plater et al.   BRITISH JOURNAL OF CANCER

PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase

(2010) Haihe Wang et al.   CANCER CELL

Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor

(2010) Raymond J. Andersen et al.   CANCER CELL

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Evaluation of systemic external microwave hyperthermia for treatment of pleural metastasis in orthotopic lung cancer model

(2010) Motomura   ONCOLOGY REPORTS

Proteomic and Genetic Approaches Identify Syk as an AML Target

(2009) Cynthia K. Hahn et al.   CANCER CELL

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Patient-derived xenografts of non-small-cell lung cancer: a pre-clinical model to evaluate adjuvant chemotherapy?☆

(2009) Johannes Merk et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice

(2009) Michael P Kim et al.   Nature Protocols

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

(2009) C. Tran et al.   SCIENCE

Argyrin A Reveals a Critical Role for the Tumor Suppressor Protein p27kip1 in Mediating Antitumor Activities in Response to Proteasome Inhibition

(2008) Irina Nickeleit et al.   CANCER CELL

Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rγnull mice generate a faster and more efficient disease compared to other NOD/scid-related strains

(2008) Alice Agliano et al.   INTERNATIONAL JOURNAL OF CANCER