Mechanisms of noncovalent β subunit regulation of Na V channel gating

Regulation of Na+channel inactivation by the DIII and DIV voltage-sensing domains

(2017) Eric J. Hsu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias

(2016) Hong-Gang Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry

(2016) Wandi Zhu et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Embryonic type Na+ channel β-subunit, SCN3B masks the disease phenotype of Brugada syndrome

(2016) Shinichiro Okata et al.   Scientific Reports

A mathematical model explains saturating axon guidance responses to molecular gradients

(2016) Huyen Nguyen et al.   eLife

Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels

(2015) Michael F. Sheets et al.   BIOPHYSICAL JOURNAL

Direct Measurement of Cardiac Na+Channel Conformations Reveals Molecular Pathologies of Inherited Mutations

(2015) Zoltan Varga et al.   Circulation-Arrhythmia and Electrophysiology

A new look at sodium channel   subunits

(2015) S. Namadurai et al.   Open Biology

Investigations of the Navβ1b sodium channel subunit in human ventricle; functional characterization of the H162P Brugada syndrome mutant

(2014) Lei Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps

(2014) Rene Barro-Soria et al.   Nature Communications

The Xenopus Oocyte Cut-open Vaseline Gap Voltage-clamp Technique With Fluorometry

(2014) Michael W. Rudokas et al.   Jove-Journal of Visualized Experiments

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: A periodic paralysis mutation in NaV1.4 (L689I)

(2013) Jonathan R. Silva et al.   JOURNAL OF GENERAL PHYSIOLOGY

Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4

(2013) Jonathan R. Silva et al.   JOURNAL OF GENERAL PHYSIOLOGY

Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels

(2013) Deborah L. Capes et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystallographic insights into sodium-channel modulation by the  4 subunit

(2013) J. Gilchrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The immunoglobulin domain of the sodium channel β3 subunit contains a surface-localized disulfide bond that is required for homophilic binding

(2012) Nikitha R. Yereddi et al.   FASEB JOURNAL

Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore–quencher pairing

(2012) Antonios Pantazis et al.   JOURNAL OF GENERAL PHYSIOLOGY

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Nav1.5 and Kv4.3 channel currents

(2011) Dan Hu et al.   HEART RHYTHM

Voltage-Gated Na+ Channel  1B: A Secreted Cell Adhesion Molecule Involved in Human Epilepsy

(2011) G. A. Patino et al.   JOURNAL OF NEUROSCIENCE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Distance Mapping in Proteins Using Fluorescence Spectroscopy: The Tryptophan-Induced Quenching (TrIQ) Method

(2010) Steven E. Mansoor et al.   BIOCHEMISTRY

Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation

(2010) Morten S. Olesen et al.   CARDIOVASCULAR RESEARCH

Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics

(2010) Manoel Arcisio-Miranda et al.   JOURNAL OF GENERAL PHYSIOLOGY

Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel   Subunits via Paradoxical Effects on Persistent Sodium Currents

(2010) M. Uebachs et al.   JOURNAL OF NEUROSCIENCE

Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channel

(2010) Yukiko Muroi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties

(2009) P. Hakim et al.   Acta Physiologica

Mutations in Sodium Channel β1- and β2-Subunits Associated With Atrial Fibrillation

(2009) Hiroshi Watanabe et al.   Circulation-Arrhythmia and Electrophysiology

Cardiac sodium channel Nav1.5 and interacting proteins: Physiology and pathophysiology

(2009) Hugues Abriel   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its β1 subunit

(2009) Victor A. Maltsev et al.   Journal of Physiological Sciences

Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties

(2009) Parvez Hakim et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels

(2008) Fabiana V. Campos et al.   JOURNAL OF GENERAL PHYSIOLOGY

Local Anesthetics Disrupt Energetic Coupling between the Voltage-sensing Segments of a Sodium Channel

(2008) Yukiko Muroi et al.   JOURNAL OF GENERAL PHYSIOLOGY