Targeting of Prosurvival Pathways as Therapeutic Approaches against Primary Effusion Lymphomas: Past, Present, and Future

Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells

(2014) Kazufumi Wakao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STAT3 activation by KSHV correlates with IL-10, IL-6 and IL-23 release and an autophagic block in dendritic cells

(2014) Roberta Santarelli et al.   Scientific Reports

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies

(2013) U. Nayar et al.   BLOOD

A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF- B

(2013) R. Gopalakrishnan et al.   CLINICAL CANCER RESEARCH

The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma

(2013) M. Chatterjee et al.   HAEMATOLOGICA

Kaposi sarcoma associated herpesvirus (KSHV) induces AKT hyperphosphorylation, bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line

(2013) Roberta Gonnella et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

(2013) Marisa Granato et al.   PLoS One

HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma

(2013) M Granato et al.   Cell Death & Disease

The Viral KSHV Chemokine vMIP-II Inhibits the Migration of Naive and Activated Human NK Cells by Antagonizing Two Distinct Chemokine Receptors

(2013) Rachel Yamin et al.   PLoS Pathogens

AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV

(2013) Aadra P. Bhatt et al.   Frontiers in Immunology

The Effects of Heat Shock Protein 90 Inhibitors on Apoptosis and Viral Replication in Primary Effusion Lymphoma Cells

(2012) Chizuka Higashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases

(2012) Britta Lamottke et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Regulation of NF-κB by ubiquitination and degradation of the IκBs

(2012) Naama Kanarek et al.   IMMUNOLOGICAL REVIEWS

Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation

(2012) David A. Braun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Effusion Lymphoma Cell Death Induced by Bortezomib and AG 490 Activates Dendritic Cells through CD91

(2012) Mara Cirone et al.   PLoS One

Targeting COX-2/PGE2 Pathway in HIPK2 Knockdown Cancer Cells: Impact on Dendritic Cell Maturation

(2012) Alessia Garufi et al.   PLoS One

JNK2 is activated during ER stress and promotes cell survival

(2012) M Raciti et al.   Cell Death & Disease

Hsp90 Inhibitors Are Efficacious against Kaposi Sarcoma by Enhancing the Degradation of the Essential Viral Gene LANA, of the Viral Co-Receptor EphA2 as well as Other Client Proteins

(2012) Wuguo Chen et al.   PLoS Pathogens

Activation of dendritic cells by tumor cell death

(2012) Mara Cirone et al.   OncoImmunology

Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines

(2011) Stacey L Fossey et al.   BMC CANCER

How to improve the immunogenicity of chemotherapy and radiotherapy

(2011) Yuting Ma et al.   CANCER AND METASTASIS REVIEWS

Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells

(2011) Thomas S. Griffith et al.   IMMUNITY

Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas

(2010) A. P. Bhatt et al.   BLOOD

Enhancement of Autophagy during Lytic Replication by the Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator

(2010) H.-J. Wen et al.   JOURNAL OF VIROLOGY

Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1

(2010) K W Wen et al.   ONCOGENE

Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells

(2009) Li   INTERNATIONAL JOURNAL OF ONCOLOGY

Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis

(2008) Ken Arita et al.   AMERICAN JOURNAL OF HUMAN GENETICS