Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination

Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro

(2016) Wenjuan Wang et al.   CANCER LETTERS

Trifluoperazine: A Sprightly Old Drug

(2016) Robert H. Howland   JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES

Radioresistance of Brain Tumors

(2016) Kevin Kelley et al.   Cancers

Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy

(2016) Chia-Hsien Wu et al.   Scientific Reports

Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage

(2015) Qing-qing Zhang et al.   ACTA PHARMACOLOGICA SINICA

The interplay between DNA repair and autophagy in cancer therapy

(2015) Dan Zhang et al.   CANCER BIOLOGY & THERAPY

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

(2015) Byeong Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy

(2015) Renata Silva et al.   PHARMACOLOGY & THERAPEUTICS

A method to measure cardiac autophagic flux in vivo

(2014) Eri Iwai-Kanai et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Combinatorial Therapy With Tamoxifen and Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades

(2014) Stephanie N. Brosius et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks

(2014) Stephen M Strittmatter   NATURE MEDICINE

Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer

(2012) Chi-Tai Yeh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases

(2012) Z. Wang et al.   CARCINOGENESIS

Molecular Pathways: Old Drugs Define New Pathways: Non-Histone Acetylation at the Crossroads of the DNA Damage Response and Autophagy

(2012) O. A. Botrugno et al.   CLINICAL CANCER RESEARCH

Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: Potential role in atherosclerosis

(2012) DANG-HENG WEI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Autophagy inhibition plays the synergetic killing roles with radiation in the multi-drug resistant SKVCR ovarian cancer cells

(2012) Bing Liang et al.   Radiation Oncology

Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S

(2011) Martin L. Biniossek et al.   JOURNAL OF PROTEOME RESEARCH

Autophagy contributes to resistance of tumor cells to ionizing radiation

(2011) Hassan Chaachouay et al.   RADIOTHERAPY AND ONCOLOGY

Impaired turnover of autophagolysosomes in cathepsin L deficiency

(2010) Julia Dennemärker et al.   BIOLOGICAL CHEMISTRY

New twists on proteasome inhibitors

(2010) Jim Kling   NATURE BIOTECHNOLOGY

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells

(2009) Keng-Fu Hsu et al.   Autophagy

Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization

(2008) M. A. Qadir et al.   BREAST CANCER RESEARCH AND TREATMENT

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs

(2007) Kristian Linnet et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY