Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy

A triterpenoid from wild bitter gourd inhibits breast cancer cells

(2016) Li-Yuan Bai et al.   Scientific Reports

Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway

(2015) Li-Yuan Bai et al.   Journal of Functional Foods

Role of AMP-Activated Protein Kinase in Cancer Therapy

(2014) Gauhar Rehman et al.   ARCHIV DER PHARMAZIE

The pro-apoptotic role of autophagy in breast cancer

(2014) S Suman et al.   BRITISH JOURNAL OF CANCER

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Current treatment of head and neck squamous cell cancer

(2014) Ryan Belcher et al.   JOURNAL OF SURGICAL ONCOLOGY

Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity

(2014) Matthias Höllerhage et al.   NEUROBIOLOGY OF AGING

Chemical structure of phenothiazines and their biological activity

(2014) Agata Jaszczyszyn et al.   Pharmacological Reports

Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma

(2014) H Wang et al.   Cell Death & Disease

Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress

(2013) Lien-Yu Chang et al.   ARCHIVES OF ORAL BIOLOGY

OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis

(2013) Li-Yuan Bai et al.   BIOCHEMICAL PHARMACOLOGY

Selaginella tamariscina Attenuates Metastasis via Akt Pathways in Oral Cancer Cells

(2013) Jia-Sin Yang et al.   PLoS One

New farnesyltransferase inhibitors in the phenothiazine series

(2012) Dalila Belei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents

(2012) Cristina-Maria Abuhaie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives

(2012) Valérie Verones et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecules and their functions in autophagy

(2012) Jong-Ok Pyo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Pharmacophore Modelling: A Forty Year Old Approach and its Modern Synergies

(2011) F. Caporuscio et al.   CURRENT MEDICINAL CHEMISTRY

Phenothiazine: the seven lives of pharmacology's first lead structure

(2011) Maike J. Ohlow et al.   DRUG DISCOVERY TODAY

N-Benzoylated Phenoxazines and Phenothiazines: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization

(2011) Helge Prinz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation

(2011) D Zong et al.   Cell Death & Disease

Protective effect of trifluoperazine on hydrogen peroxide-induced apoptosis in PC12 cells

(2010) Shichang Liu et al.   BRAIN RESEARCH BULLETIN

Targeting autophagy to fight hematopoietic malignancies

(2010) Alexandre Puissant et al.   CELL CYCLE

A systems level strategy for analyzing the cell death network: implication in exploring the apoptosis/autophagy connection

(2010) E Zalckvar et al.   CELL DEATH AND DIFFERENTIATION

Multiple non-psychiatric effects of phenothiazines: A review

(2010) Gangopadhyay Sudeshna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic

(2008) Andy T.Y. Lau et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Head and neck cancer

(2008) Athanassios Argiris et al.   LANCET