High body clearance and low oral bioavailability of alantolactone, isolated fromInula helenium, in rats: extensive hepatic metabolism and low stability in gastrointestinal fluids

Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells

(2015) Jaemoo Chun et al.   CANCER LETTERS

Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of Radix Inulae Extract

(2015) Renjie Xu et al.   MOLECULES

Absorption, tissue distribution, tissue metabolism and safety of α-mangostin in mangosteen extract using mouse models

(2014) Young Hee Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

Simultaneous determination of sesquiterpene lactones isoalantolactone and alantolactone isomers in rat plasma by liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study

(2014) Chunjie Guo et al.   JOURNAL OF SEPARATION SCIENCE

In Vitro and In Vivo Evaluation of the Effect of Puerarin on Hepatic Cytochrome P450-Mediated Drug Metabolism

(2014) Sang-Bum Kim et al.   PLANTA MEDICA

Stability of stock and diluted rituximab

(2013) Y. Zhang et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice

(2013) Eun Jung Park et al.   FOOD AND CHEMICAL TOXICOLOGY

The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin

(2012) Ji-Eon Kim et al.   XENOBIOTICA

Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats

(2012) Insoo Yoon et al.   XENOBIOTICA

Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica

(2012) Yong Li et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity

(2011) Siamak Cyrus Khojasteh et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol

(2010) In-Soo Yoon et al.   XENOBIOTICA

Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

(2009) Prati Bajracharya et al.   ARCHIVES OF PHARMACAL RESEARCH

Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans

(2009) T. Watanabe et al.   DRUG METABOLISM AND DISPOSITION

HPLC determination and NMR structural elucidation of sesquiterpene lactones in Inula helenium

(2009) Yan Huo et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Antimicrobial activity of Inula helenium L. essential oil against Gram-positive and Gram-negative bacteria and Candida spp.

(2008) Antonella Deriu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS