Mimicking exercise in three-dimensional bioengineered skeletal muscle to investigate cellular and molecular mechanisms of physiological adaptation

Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise

(2016) Adam P. Sharples et al.   AGING CELL

Factors That Affect Tissue-Engineered Skeletal Muscle Function and Physiology

(2016) Alastair Khodabukus et al.   CELLS TISSUES ORGANS

Creating Interactions between Tissue-Engineered Skeletal Muscle and the Peripheral Nervous System

(2016) Alec S.T. Smith et al.   CELLS TISSUES ORGANS

Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model

(2016) James C. Evans et al.   MOLECULAR PHARMACEUTICS

Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues

(2016) Cindy S. Cheng et al.   TISSUE ENGINEERING PART A

A novel bioreactor for the generation of highly aligned 3D skeletal muscle-like constructs through orientation of fibrin via application of static strain

(2015) Philipp Heher et al.   Acta Biomaterialia

A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy

(2015) Daniel J. Owens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases

(2015) Diana Romero et al.   CARCINOGENESIS

Contractile and Metabolic Properties of Engineered Skeletal Muscle Derived From Slow and Fast Phenotype Mouse Muscle

(2015) Alastair Khodabukus et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of contraction duration in inducing fast-to-slow contractile and metabolic protein and functional changes in engineered muscle

(2015) Alastair Khodabukus et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neuromuscular Junction Formation in Tissue-Engineered Skeletal Muscle Augments Contractile Function and Improves Cytoskeletal Organization

(2015) Neil R.W. Martin et al.   TISSUE ENGINEERING PART A

Roles of adherent myogenic cells and dynamic culture in engineered muscle function and maintenance of satellite cells

(2014) Mark Juhas et al.   BIOMATERIALS

Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle

(2014) D. J. Player et al.   BIOTECHNOLOGY LETTERS

A Genetically Modified Protein-Based Hydrogel for 3D Culture of AD293 Cells

(2014) Xiao Du et al.   PLoS One

Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo

(2014) M. Juhas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway

(2013) Hannah Crossland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Use of Flow, Electrical, and Mechanical Stimulation to Promote Engineering of Striated Muscles

(2013) Swathi Rangarajan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Three-dimensional neuron–muscle constructs with neuromuscular junctions

(2013) Yuya Morimoto et al.   BIOMATERIALS

Factors affecting the structure and maturation of human tissue engineered skeletal muscle

(2013) Neil R.W. Martin et al.   BIOMATERIALS

The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy

(2013) Adam P. Sharples et al.   GROWTH HORMONE & IGF RESEARCH

Mechanical-Stretch of C2C12 Myoblasts Inhibits Expression of Toll-Like Receptor 3 (TLR3) and of Autoantigens Associated with Inflammatory Myopathies

(2013) Rong Chen et al.   PLoS One

Engineering muscle constructs for the creation of functional engineered musculoskeletal tissue

(2013) Jacob P Mertens et al.   Regenerative Medicine

Modellingin vivoskeletal muscle ageingin vitrousing three-dimensional bioengineered constructs

(2012) Adam P. Sharples et al.   AGING CELL

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise

(2012) Nataša Nikolić et al.   PLoS One

The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle

(2011) Sara Hinds et al.   BIOMATERIALS

Myoblast models of skeletal muscle hypertrophy and atrophy

(2011) Adam P Sharples et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

(2011) Anne-Françoise Richard et al.   DEVELOPMENTAL BIOLOGY

Characterization and optimization of a simple, repeatable system for the long term in vitro culture of aligned myotubes in 3D

(2011) A.S.T. Smith et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling

(2011) Mitsunori Miyazaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mechanoregulation of Vascularization in Aligned Tissue-Engineered Muscle: A Role for Vascular Endothelial Growth Factor

(2011) Daisy W.J. van der Schaft et al.   TISSUE ENGINEERING PART A

Induction ofSirt1by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response

(2010) Patricia S. Pardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: Relevance to disease and ageing?

(2010) Adam P. Sharples et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The effect of cell density on the maturation and contractile ability of muscle derived cells in a 3D tissue-engineered skeletal muscle model and determination of the cellular and mechanical stimuli required for the synthesis of a postural phenotype

(2010) V. Mudera et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Advanced maturation by electrical stimulation: Differences in response between C2C12 and primary muscle progenitor cells

(2010) Marloes L. P. Langelaan et al.   Journal of Tissue Engineering and Regenerative Medicine

PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice

(2009) Lotte Leick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscleThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) David A. Hood   Applied Physiology Nutrition and Metabolism

Differentiation rather than aging of muscle stem cells abolishes their telomerase activity

(2009) Matthew S. O'Connor et al.   BIOTECHNOLOGY PROGRESS

Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome

(2009) Claire Niro et al.   DEVELOPMENTAL BIOLOGY

Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells

(2009) P. J. Atherton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Human Muscle Gene Expression following Resistance Exercise and Blood Flow Restriction

(2009) MICAH J. DRUMMOND et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle

(2008) Taku Nedachi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of Electromechanical Stimulation on the Maturation of Myotubes on Aligned Electrospun Fibers

(2008) I-Chien Liao et al.   Cellular and Molecular Bioengineering

Effects of electrical stimulation in C2C12 muscle constructs

(2008) Hyoungshin Park et al.   Journal of Tissue Engineering and Regenerative Medicine