Does skeletal muscle have an ‘epi’-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

(2016) Ida Donkin et al.   Cell Metabolism

Muscle memory and a new cellular model for muscle atrophy and hypertrophy

(2016) Kristian Gundersen   JOURNAL OF EXPERIMENTAL BIOLOGY

DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation

(2016) Rhianna C. Laker et al.   Stem Cells International

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

(2015) Adam P. Sharples et al.   AGING CELL

Skeletal muscle cells possess a ‘memory’ of acute early life TNF-α exposure: role of epigenetic adaptation

(2015) Adam P. Sharples et al.   BIOGERONTOLOGY

Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to maternal nutrition

(2015) Huan Wang et al.   BRITISH JOURNAL OF NUTRITION

High-Fat Diet During Mouse Pregnancy and Lactation Targets GIP-Regulated Metabolic Pathways in Adult Male Offspring

(2015) Michael Kruse et al.   DIABETES

Effects of sleeping with reduced carbohydrate availability on acute training responses

(2015) Stephen C. Lane et al.   JOURNAL OF APPLIED PHYSIOLOGY

High-Protein Exposure during Gestation or Lactation or after Weaning Has a Period-Specific Signature on Rat Pup Weight, Adiposity, Food Intake, and Glucose Homeostasis up to 6 Weeks of Age

(2015) Caroline Desclée de Maredsous et al.   JOURNAL OF NUTRITION

Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low-protein diet

(2015) Kate J. Claycombe et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of aging and maternal protein restriction on the muscle fibers morphology and neuromuscular junctions of rats after nutritional recovery

(2015) Heloisa Deola Confortim et al.   MICRON

Lipid exposure elicits differential responses in gene expression and DNA methylation in primary human skeletal muscle cells from severely obese women

(2015) Jill M. Maples et al.   PHYSIOLOGICAL GENOMICS

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Age-Associated Methylation Suppresses SPRY1 , Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle

(2015) Anne Bigot et al.   Cell Reports

Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice

(2015) Timothy L. Lochmann et al.   PLoS One

RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

(2015) Valérie Grandjean et al.   Scientific Reports

Epigenetic Change as the Major Mediator of Fetal Programming in Humans: Are We There Yet?

(2014) Richard Saffery   ANNALS OF NUTRITION AND METABOLISM

Maternal protein restriction impairs the transcriptional metabolic flexibility of skeletal muscle in adult rat offspring

(2014) Raquel da Silva Aragão et al.   BRITISH JOURNAL OF NUTRITION

Lean Mass, Muscle Strength and Gene Expression in Community Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

(2014) Harnish P. Patel et al.   CALCIFIED TISSUE INTERNATIONAL

Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of thePgc-1αGene and Age-Dependent Metabolic Dysfunction in the Offspring

(2014) Rhianna C. Laker et al.   DIABETES

Gestational Protein Restriction Impairs Insulin-Regulated Glucose Transport Mechanisms in Gastrocnemius Muscles of Adult Male Offspring

(2014) Chellakkan S. Blesson et al.   ENDOCRINOLOGY

Maternal low-protein diet affects myostatin signaling and protein synthesis in skeletal muscle of offspring piglets at weaning stage

(2014) Xiujuan Liu et al.   EUROPEAN JOURNAL OF NUTRITION

Epigenetic control of adult skeletal muscle stem cell functions

(2014) Jessica Segalés et al.   FEBS Journal

Wnt Protein-mediated Satellite Cell Conversion in Adult and Aged Mice Following Voluntary Wheel Running

(2014) Shin Fujimaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maternal Overnutrition Programs Changes in the Expression of Skeletal Muscle Genes That Are Associated with Insulin Resistance and Defects of Oxidative Phosphorylation in Adult Male Rat Offspring

(2014) Celine Latouche et al.   JOURNAL OF NUTRITION

Postnatal exposure to a high-carbohydrate diet interferes epigenetically with thyroid hormone receptor induction of the adult male rat skeletal muscle glucose transporter isoform 4 expression

(2014) Nupur Raychaudhuri et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Myoblasts from intrauterine growth-restricted sheep fetuses exhibit intrinsic deficiencies in proliferation that contribute to smaller semitendinosus myofibres

(2014) Dustin T. Yates et al.   JOURNAL OF PHYSIOLOGY-LONDON

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Post-Receptor Crosstalk between Growth Hormone and Insulin Signal in Rats Born Small for Gestational Age with Catch-Up Growth

(2014) Hong-Zhu Deng et al.   PLoS One

Epigenetic inheritance: histone bookmarks across generations

(2014) Eric I. Campos et al.   TRENDS IN CELL BIOLOGY

Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging

(2014) Nazif Alic et al.   Cell Reports

Epigenetic Regulation by Heritable RNA

(2014) Reinhard Liebers et al.   PLoS Genetics

Primary human muscle precursor cells obtained from young and old donors produce similar proliferative, differentiation and senescent profiles in culture

(2013) Mansour Alsharidah et al.   AGING CELL

Genome-wide DNA methylation changes with age in disease-free human skeletal muscle

(2013) Artem Zykovich et al.   AGING CELL

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

(2013) Alika K Maunakea et al.   CELL RESEARCH

Heightened muscle inflammation susceptibility may impair regenerative capacity in aging humans

(2013) Edward K. Merritt et al.   JOURNAL OF APPLIED PHYSIOLOGY

Physical activity is associated with retained muscle metabolism in human myotubes challenged with palmitate

(2013) C. J. Green et al.   JOURNAL OF PHYSIOLOGY-LONDON

Remembering those ‘lazy’ days - imprinting memory in our satellite cells

(2013) Ana P. Valencia et al.   JOURNAL OF PHYSIOLOGY-LONDON

A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids

(2013) Ingrid M. Egner et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impaired Hypothalamic mTOR Activation in the Adult Rat Offspring Born to Mothers Fed a Low-Protein Diet

(2013) Omar Guzmán-Quevedo et al.   PLoS One

Lower Maternal Body Condition During Pregnancy Affects Skeletal Muscle Structure and Glut-4 Protein Levels But Not Glucose Tolerance in Mature Adult Sheep

(2013) Paula M. Costello et al.   Reproductive Sciences

The developmental origins of ageing: study protocol for the Dutch famine birth cohort study on ageing

(2013) Susanne R de Rooij et al.   BMJ Open

Modellingin vivoskeletal muscle ageingin vitrousing three-dimensional bioengineered constructs

(2012) Adam P. Sharples et al.   AGING CELL

TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

(2012) Svetlana Petruk et al.   CELL

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

(2012) Romain Barrès et al.   Cell Metabolism

Non-passaged muscle precursor cells from 32-month old rat skeletal muscle have delayed proliferation and differentiation

(2012) K. A. Zwetsloot et al.   CELL PROLIFERATION

Coordination of Satellite Cell Activation and Self-Renewal by Par-Complex-Dependent Asymmetric Activation of p38α/β MAPK

(2012) Andrew Troy et al.   Cell Stem Cell

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

(2012) M. D. Nitert et al.   DIABETES

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men

(2012) S. C. Jacobsen et al.   DIABETOLOGIA

High Resolution Methylome Map of Rat Indicates Role of Intragenic DNA Methylation in Identification of Coding Region

(2012) Satish Sati et al.   PLoS One

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

(2012) Laura Tornatore et al.   TRENDS IN CELL BIOLOGY

DNA Demethylation Dynamics

(2011) Nidhi Bhutani et al.   CELL

Epigenetic inheritance of cell differentiation status

(2011) Ray K. Ng et al.   CELL CYCLE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Myoblast models of skeletal muscle hypertrophy and atrophy

(2011) Adam P Sharples et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo

(2011) Anders H Olsson et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol

(2011) Amarjit Saini et al.   EXPERIMENTAL PHYSIOLOGY

Reduction of myoblast differentiation following multiple population doublings in mouse C2C12 cells: A model to investigate ageing?

(2011) Adam P. Sharples et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

In epidemiological studies: Findings from the hertfordshire sarcopenia study (HSS)

(2011) Harnish Patel et al.   Journal of Nutrition Health & Aging

Age-related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species

(2011) Malcolm J. Jackson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sca-1-Expressing Nonmyogenic Cells Contribute to Fibrosis in Aged Skeletal Muscle

(2011) M. Hidestrand et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Detraining and Retraining in Older Adults Following Long-Term Muscle Power or Muscle Strength Specific Training

(2011) T. R. Henwood et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Developmental Origins of Sarcopenia: Using Peripheral Quantitative Computed Tomography to Assess Muscle Size in Older People

(2011) A. A. Sayer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Developmental Influences, Muscle Morphology, and Sarcopenia in Community-Dwelling Older Men

(2011) H. P. Patel et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages

(2011) Prashanth Kumar Kandalla et al.   MECHANISMS OF AGEING AND DEVELOPMENT

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Early Life Nutrition Modulates Muscle Stem Cell Number: Implications for Muscle Mass and Repair

(2011) Melissa Woo et al.   STEM CELLS AND DEVELOPMENT

Epigenetic regulation of satellite cell activation during muscle regeneration

(2011) F Jeffrey Dilworth et al.   Stem Cell Research & Therapy

Aberrant repair and fibrosis development in skeletal muscle

(2011) Christopher J Mann et al.   Skeletal Muscle

Human muscle satellite cells show age-related differential expression of S100B protein and RAGE

(2010) Sara Beccafico et al.   AGE

Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients

(2010) C. Aguer et al.   DIABETOLOGIA

Regulation and dysregulation of fibrosis in skeletal muscle

(2010) Antonio L. Serrano et al.   EXPERIMENTAL CELL RESEARCH

C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: Relevance to disease and ageing?

(2010) Adam P. Sharples et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Satellite cell characterization from aging human muscle

(2010) Arianna Corbu et al.   NEUROLOGICAL RESEARCH

Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining

(2010) J. C. Bruusgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hertfordshire sarcopenia study: design and methods

(2010) Harnish P Patel et al.   BMC Geriatrics

Maternal obesity downregulates myogenesis and β-catenin signaling in fetal skeletal muscle

(2009) Jun F. Tong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice

(2009) Piran Shelley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice

(2009) Maqsood M. Elahi et al.   BRITISH JOURNAL OF NUTRITION

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density

(2009) Romain Barrès et al.   Cell Metabolism

DNA methylation and methyl-CpG binding proteins: developmental requirements and function

(2009) Ozren Bogdanović et al.   CHROMOSOMA

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

(2009) Tiziana Pietrangelo et al.   EXPERIMENTAL GERONTOLOGY

Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity

(2009) C. Schmidl et al.   GENOME RESEARCH

Exercise-induced histone modifications in human skeletal muscle

(2009) Sean L. McGee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the Glut4 gene

(2008) James A. H. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Replicative aging down-regulates the myogenic regulatory factors in human myoblasts

(2008) Anne Bigot et al.   BIOLOGY OF THE CELL

Alterations in Muscle Attenuation following Detraining and Retraining in Resistance-Trained Older Adults

(2008) Dennis R. Taaffe et al.   GERONTOLOGY

IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis

(2008) Nadine Bakkar et al.   JOURNAL OF CELL BIOLOGY

Nuclear factor-kappa B signaling in skeletal muscle atrophy

(2008) Hong Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development

(2008) Paula M. Costello et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep

(2008) Mei J. Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

A model for transmission of the H3K27me3 epigenetic mark

(2008) Klaus H. Hansen et al.   NATURE CELL BIOLOGY

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance

(2007) Anne-Maj Samuelsson et al.   HYPERTENSION