The novel role of pyrvinium in cancer therapy

Role of Systemic Chemotherapy in Urothelial Urinary Bladder Cancer

(2017) Shilpa Gupta et al.   Cancer Control

Pyrvinium selectively induces apoptosis of lymphoma cells through impairing mitochondrial functions and JAK2/STAT5

(2016) Meifang Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds

(2016) Diego Carrella et al.   Oncotarget

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder

(2016) Jiawei Guo et al.   Oncotarget

Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells

(2015) A Grimaldi et al.   CANCER BIOLOGY & THERAPY

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells

(2015) C. Venugopal et al.   CLINICAL CANCER RESEARCH

First-line Treatment of Metastatic Disease

(2015) Richard Cathomas et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Levofolene modulates apoptosis induced by 5-fluorouracil through autophagy inhibition: Clinical and occupational implications

(2015) MONICA LAMBERTI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development

(2015) A M Roncero et al.   LEUKEMIA

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia

(2015) Meili Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration

(2015) Wei Xiang et al.   Oncotarget

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

Molecular Pathogenesis of Peripheral T Cell Lymphoma

(2015) Mamiko Sakata-Yanagimoto et al.   Current Hematologic Malignancy Reports

Targeting Autophagy Addiction in Cancer

(2015) Joseph D. Mancias et al.   Oncotarget

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

(2015) Rebecca Lamb et al.   Oncotarget

Pyrvinium Attenuates Hedgehog Signaling Downstream of Smoothened

(2014) Bin Li et al.   CANCER RESEARCH

The role of DNA repair pathways in cisplatin resistant lung cancer

(2014) Shane O’Grady et al.   CANCER TREATMENT REVIEWS

The impact of pyrvinium pamoate on colon cancer cell viability

(2014) Armin Wiegering et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

(2014) Bin Li et al.   PLoS One

Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

(2014) Christian Jekimovs et al.   Frontiers in Oncology

Ligand-Independent and Tissue-Selective Androgen Receptor Inhibition by Pyrvinium

(2013) Minyoung Lim et al.   ACS Chemical Biology

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

The expression status of CD133 is associated with the pattern and timing of primary glioblastoma recurrence

(2013) Ichiyo Shibahara et al.   NEURO-ONCOLOGY

Histone Acetylation-Mediated Regulation of the Hippo Pathway

(2013) Dipanjan Basu et al.   PLoS One

The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

(2013) Wei Xu et al.   PLoS One

The Synergistic Effect of Everolimus and Chloroquine on Endothelial Cell Number Reduction Is Paralleled by Increased Apoptosis and Reduced Autophagy Occurrence

(2013) Anna Grimaldi et al.   PLoS One

Pyrvinium targets autophagy addiction to promote cancer cell death

(2013) Longfei Deng et al.   Cell Death & Disease

Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities

(2012) Mary E. Irwin et al.   ANTIOXIDANTS & REDOX SIGNALING

How I treat CML blast crisis

(2012) R. Hehlmann   BLOOD

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for Urothelial Carcinoma—Neoadjuvant and Adjuvant Settings

(2012) Cora N. Sternberg et al.   EUROPEAN UROLOGY

New Synthesis of Pyrvinium That inhibits the β-Catenin/Tcf4 Pathway

(2012) Jing An et al.   HETEROCYCLES

An anticancer agent, pyrvinium pamoate inhibits the NADH–fumarate reductase system—a unique mitochondrial energy metabolism in tumour microenvironments

(2012) Eriko Tomitsuka et al.   JOURNAL OF BIOCHEMISTRY

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

(2012) Wei Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hippo Pathway

(2012) K. F. Harvey et al.   Cold Spring Harbor Perspectives in Biology

Mouse Skeletal Muscle Fiber-Type-Specific Macroautophagy and Muscle Wasting Are Regulated by a Fyn/STAT3/Vps34 Signaling Pathway

(2012) Eijiro Yamada et al.   Cell Reports

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3

(2011) Yasuo Harada et al.   CANCER LETTERS

Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants

(2011) Elahe A. Mostaghel et al.   CLINICAL CANCER RESEARCH

Inducing Indigestion: Companies Embrace Autophagy Inhibitors

(2011) K. Garber   JNCI-Journal of the National Cancer Institute

TAZ is a novel oncogene in non-small cell lung cancer

(2011) Z Zhou et al.   ONCOGENE

Suppression of Casein Kinase 1  in Melanoma Cells Induces a Switch in  -Catenin Signaling to Promote Metastasis

(2010) T. Sinnberg et al.   CANCER RESEARCH

Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer

(2010) Yang Wang et al.   CANCER SCIENCE

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

(2010) Yi Arial Zeng et al.   Cell Stem Cell

TAZ/WWTR1 is overexpressed in papillary thyroid carcinoma

(2010) Tiziana de Cristofaro et al.   EUROPEAN JOURNAL OF CANCER

Novel strategies for treating relapsed/refractory urothelial carcinoma

(2010) Gopa Iyer et al.   Expert Review of Anticancer Therapy

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

(2010) Sarika Saraswati et al.   PLoS One

Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

(2009) E. Charafe-Jauffret et al.   CLINICAL CANCER RESEARCH

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

(2009) Julia Bollrath et al.   EMBO REPORTS

Non-competitive androgen receptor inhibition in vitro and in vivo

(2009) J. O. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110  Predisposes Mammary Glands to Neoplastic Transformation

(2008) O. Renner et al.   CANCER RESEARCH

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

(2008) V. Serra et al.   CANCER RESEARCH

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

(2008) F. Zeppernick et al.   CLINICAL CANCER RESEARCH

Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance

(2008) Nadine N. Bewry et al.   MOLECULAR CANCER THERAPEUTICS

Pyrvinium Targets the Unfolded Protein Response to Hypoglycemia and Its Anti-Tumor Activity Is Enhanced by Combination Therapy

(2008) De-Hua Yu et al.   PLoS One