Molecular Pathogenesis of Peripheral T Cell Lymphoma

Multistep tumorigenesis in peripheral T cell lymphoma

(2015) Mamiko Sakata-Yanagimoto   INTERNATIONAL JOURNAL OF HEMATOLOGY

Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation

(2015) Olaf Merkel et al.   JOURNAL OF PATHOLOGY

ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes

(2014) E. R. Parrilla Castellar et al.   BLOOD

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia

(2014) M. J. Kiel et al.   BLOOD

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

(2014) J. Iqbal et al.   BLOOD

Disease-specific mutations in mature lymphoid neoplasms: Recent advances

(2014) Mamiko Sakata-Yanagimoto et al.   CANCER SCIENCE

Identification of putative pathogenic microRNA and its downstream targets in anaplastic lymphoma kinase–negative anaplastic large cell lymphoma

(2014) Meenakshi Mehrotra et al.   HUMAN PATHOLOGY

TET proteins and 5-methylcytosine oxidation in hematological cancers

(2014) Myunggon Ko et al.   IMMUNOLOGICAL REVIEWS

The Epstein-Barr virus and the pathogenesis of lymphoma

(2014) Martina Vockerodt et al.   JOURNAL OF PATHOLOGY

Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas

(2014) A Nicolae et al.   LEUKEMIA

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice

(2014) H Muto et al.   Blood Cancer Journal

Epstein-Barr Virus–Encoded miR-BART20-5p Inhibits T-bet Translation with Secondary Suppression of p53 in Invasive Nasal NK/T-Cell Lymphoma

(2013) Ting-Chu Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia

(2013) O. Abdel-Wahab et al.   BLOOD

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

(2013) H. L. M. Rajala et al.   BLOOD

Comprehensive gene expression profiles of NK cell neoplasms identify vorinostat as an effective drug candidate

(2013) Kennosuke Karube et al.   CANCER LETTERS

Molecular Profiling Improves Classification and Prognostication of Nodal Peripheral T-Cell Lymphomas: Results of a Phase III Diagnostic Accuracy Study

(2013) Pier Paolo Piccaluga et al.   JOURNAL OF CLINICAL ONCOLOGY

Premature Terminal Differentiation Protects from Deregulated Lymphocyte Activation by ITK-Syk

(2013) M. P. Bach et al.   JOURNAL OF IMMUNOLOGY

JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma

(2013) A Bouchekioua et al.   LEUKEMIA

STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia

(2013) R S Ohgami et al.   LEUKEMIA

Rare occurrence ofJAK3mutations in natural killer cell neoplasms in Japan

(2013) Hiroshi Kimura et al.   LEUKEMIA & LYMPHOMA

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

ROQUIN/RC3H1 Alterations Are Not Found in Angioimmunoblastic T-Cell Lymphoma

(2013) Tiphanie Auguste et al.   PLoS One

Pathogenesis and Treatment of Extranodal Natural Killer/T-Cell Lymphoma

(2013) Ritsuro Suzuki   SEMINARS IN HEMATOLOGY

Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

(2012) J. I. Ellyard et al.   BLOOD

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

(2012) A. Jerez et al.   BLOOD

Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas

(2012) G. Vasmatzis et al.   BLOOD

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

(2012) F. Lemonnier et al.   BLOOD

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

(2012) R. A. Cairns et al.   BLOOD

Angioimmunoblastic T-cell lymphoma mice model

(2012) Fumihiko Sato et al.   LEUKEMIA RESEARCH

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas

(2012) Daniela Laimer et al.   NATURE MEDICINE

TET2andDNMT3AMutations in Human T-Cell Lymphoma

(2012) Lucile Couronné et al.   NEW ENGLAND JOURNAL OF MEDICINE

ALKoma: A Cancer Subtype with a Shared Target

(2012) Hiroyuki Mano   Cancer Discovery

Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma

(2012) Ghee Chong Koo et al.   Cancer Discovery

Epstein-Barr Virus and the Pathogenesis of T and NK Lymphoma: a Mystery Unsolved

(2012) Lindsay C. George et al.   Current Hematologic Malignancy Reports

Dysregulated microRNAs affect pathways and targets of biologic relevance in nasal-type natural killer/T-cell lymphoma

(2011) S.-B. Ng et al.   BLOOD

MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression

(2011) C. Desjobert et al.   BLOOD

Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses

(2011) K. Karube et al.   BLOOD

miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma

(2011) H. Matsuyama et al.   BLOOD

Expression of follicular helper T cell markers in nodal peripheral T cell lymphomas: a tissue microarray analysis of 162 cases

(2011) H.-Q. Zhan et al.   JOURNAL OF CLINICAL PATHOLOGY

Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas

(2011) E Dejean et al.   LEUKEMIA

PRDM1 is a tumor suppressor gene in natural killer cell malignancies

(2011) C. Kucuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing

(2010) A. L. Feldman et al.   BLOOD

The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease

(2010) C. Dierks et al.   CANCER RESEARCH

Gene Expression Profiling Uncovers Molecular Classifiers for the Recognition of Anaplastic Large-Cell Lymphoma Within Peripheral T-Cell Neoplasms

(2010) Roberto Piva et al.   JOURNAL OF CLINICAL ONCOLOGY

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

(2010) Konstanze Pechloff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro

(2010) J Iqbal et al.   LEUKEMIA

Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma

(2010) O. Merkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral T-cell Lymphomas With a Follicular Growth Pattern are Derived From Follicular Helper T Cells (TFH) and may Show Overlapping Features With Angioimmunoblastic T-cell Lymphomas

(2009) Yenlin Huang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways

(2009) M. S. Lim et al.   BLOOD

Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type

(2009) Y. Huang et al.   BLOOD

Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

(2009) J. Iqbal et al.   BLOOD

Advances in the understanding and management of angioimmunoblastic T-cell lymphoma

(2009) Laurence de Leval et al.   BRITISH JOURNAL OF HAEMATOLOGY

NPM-ALK Oncogenic Tyrosine Kinase Controls T-Cell Identity by Transcriptional Regulation and Epigenetic Silencing in Lymphoma Cells

(2009) C. Ambrogio et al.   CANCER RESEARCH

How are TH1 and TH2 effector cells made?

(2009) Derk Amsen et al.   CURRENT OPINION IN IMMUNOLOGY

Peripheral T-cell Lymphoma With Follicular T-cell Markers

(2008) Socorro María Rodríguez-Pinilla et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY