Ebselen impairs cellular oxidative state and induces endoplasmic reticulum stress and activation of crucial mitogen-activated protein kinases in pancreatic tumour AR42J cells

Protection of rat liver against hepatic ischemia-reperfusion injury by a novel selenocysteine-containing 7-mer peptide

(2016) Qianqian Jiang et al.   Molecular Medicine Reports

Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes

(2016) Patricia Santofimia-Castaño et al.   TOXICOLOGY

Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents

(2015) Jun Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Basic mechanisms in endoplasmic reticulum stress and relation to cardiovascular diseases

(2015) Erdi Sozen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of copper accumulation and copper-induced toxicity by antioxidants and copper chelators in cultured primary brain astrocytes

(2015) Felix Bulcke et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Streptozotocin induces endoplasmic reticulum stress and apoptosis via disruption of calcium homeostasis in mouse pancreas

(2015) Changhwan Ahn et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

(2015) Jeng Yie Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines

(2015) Paul D. Hanavan et al.   Oncotarget

Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication

(2014) Sourav Mukherjee et al.   ACS Chemical Biology

Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview

(2014) Estefanie Dufey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Histidine-Tryptophan-Ketoglutarate Solution With Added Ebselen Augments Myocardial Protection in Neonatal Porcine Hearts Undergoing Ischemia/Reperfusion

(2014) Yan Chen et al.   ARTIFICIAL ORGANS

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

(2014) Nicola J. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ebselen exhibits glycation-inhibiting properties and protects against osmotic fragility of human erythrocytes in vitro

(2014) Julio C. M. Soares et al.   CELL BIOLOGY INTERNATIONAL

Endoplasmic reticulum stress in insulin resistance and diabetes

(2014) Agustin Guerrero-Hernández et al.   CELL CALCIUM

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

(2014) Anna-Liisa Levonen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils

(2014) S. Park et al.   FREE RADICAL RESEARCH

Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways

(2014) Gajendra Kumar Azad et al.   MOLECULAR BIOLOGY REPORTS

The seleno-organic compound ebselen impairs mitochondrial physiology and induces cell death in AR42J cells

(2014) Patricia Santofimia-Castaño et al.   TOXICOLOGY LETTERS

The early research and development of ebselen

(2013) Michael J. Parnham et al.   BIOCHEMICAL PHARMACOLOGY

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage

(2013) Feng-Jin Guo et al.   CELLULAR SIGNALLING

Ebselen Alters Mitochondrial Physiology and Reduces Viability of Rat Hippocampal Astrocytes

(2013) Patricia Santofimia-Castaño et al.   DNA AND CELL BIOLOGY

Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway

(2013) YING-YING CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+handling in ageing rabbit hearts

(2013) Leroy L. Cooper et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reactive Oxygen Species via Redox Signaling to PI3K/AKT Pathway Contribute to the Malignant Growth of 4-Hydroxy Estradiol-Transformed Mammary Epithelial Cells

(2013) Victor O. Okoh et al.   PLoS One

Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress

(2012) Daiana Silva Avila et al.   FREE RADICAL BIOLOGY AND MEDICINE

XBP1S protects cells from ER stress-induced apoptosis through Erk1/2 signaling pathway involving CHOP

(2012) Feng-Jin Guo et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mitochondrial electron transfer chain complexes inhibition by different organochalcogens

(2012) Robson L. Puntel et al.   TOXICOLOGY IN VITRO

The endoplasmic reticulum stress response in aging and age-related diseases

(2012) Marishka K. Brown et al.   Frontiers in Physiology

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

(2011) Michael P. Murphy   ANTIOXIDANTS & REDOX SIGNALING

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds

(2011) Cristina W. Nogueira et al.   ARCHIVES OF TOXICOLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen

(2011) Sonia Antony et al.   INORGANIC CHEMISTRY

Thiol redox proteomics seen with fluorescent eyes: The detection of cysteine oxidative modifications by fluorescence derivatization and 2-DE

(2011) Alicia Izquierdo-Álvarez et al.   Journal of Proteomics

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity

(2010) Marita Wallenberg et al.   BIOCHEMICAL JOURNAL

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFα)-induced apoptosis through two distinct pathways involving NF-κB downregulation and Fas-mediated formation of death inducing signaling complex

(2008) Vivek Sharma et al.   INTERNATIONAL JOURNAL OF CANCER

Ebselen increases cytosolic free Ca2+ concentration, stimulates glutamate release and increases GFAP content in rat hippocampal astrocytes

(2008) Miguel Salazar et al.   TOXICOLOGY