Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways

An ebselen like catalyst with enhanced GPx activity via a selenol intermediate

(2014) Shah Jaimin Balkrishna et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target

(2014) Gajendra Kumar Azad et al.   FEBS Open Bio

Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase

(2013) Michael T. Harris et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves  -Cell Mass and Function in ZDF Rats

(2013) J. Mahadevan et al.   DIABETES

Ebselen Alters Mitochondrial Physiology and Reduces Viability of Rat Hippocampal Astrocytes

(2013) Patricia Santofimia-Castaño et al.   DNA AND CELL BIOLOGY

Synthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer’s Disease Based on the Fusion of Donepezil and Ebselen

(2013) Zonghua Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen

(2013) Lorenza Favrot et al.   Nature Communications

A safe lithium mimetic for bipolar disorder

(2013) Nisha Singh et al.   Nature Communications

Ebselen and Congeners Inhibit NADPH Oxidase 2-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits

(2012) Susan M.E. Smith et al.   CHEMISTRY & BIOLOGY

Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen

(2012) Jade B. Aitken et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Lithium toxicity profile: a systematic review and meta-analysis

(2012) Rebecca F McKnight et al.   LANCET

Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake

(2012) Ling Xie et al.   NEUROCHEMISTRY INTERNATIONAL

A near-infrared reversible fluorescent probe for real-time imaging of redox status changes in vivo

(2012) Kehua Xu et al.   Chemical Science

Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins

(2011) Gajendra K. Azad et al.   BIOCHEMICAL PHARMACOLOGY

The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains

(2011) Cristiane L. Dalla Corte et al.   BRAIN RESEARCH

Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer

(2011) Behrooz Kasraee et al.   EXPERIMENTAL DERMATOLOGY

Reactive oxygen species in cardiovascular disease

(2011) Koichi Sugamura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen

(2011) Sonia Antony et al.   INORGANIC CHEMISTRY

Neuroprotective Effects of Ebselen Following Forebrain Ischemia: Involvement of Glutamate and Nitric Oxide

(2011) Hiroyasu KOIZUMI et al.   NEUROLOGIA MEDICO-CHIRURGICA

Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen

(2011) Zhaobao Yin et al.   NEUROTOXICOLOGY

Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity

(2011) A.P. Marreilha dos Santos et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Study of Highly Selective and Efficient Thiol Derivatization Using Selenium Reagents by Mass Spectrometry

(2010) Kehua Xu et al.   ANALYTICAL CHEMISTRY

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse

(2010) P. Chew et al.   DIABETES

Inhibitory effect of ebselen on lactate dehydrogenase activity from mammals: a comparative study with diphenyl diselenide and diphenyl ditelluride

(2010) Thiago H. Lugokenski et al.   DRUG AND CHEMICAL TOXICOLOGY

Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling

(2010) Shan Soe-Lin et al.   EXPERIMENTAL HEMATOLOGY

Post-transcriptional Defects of Antioxidant Selenoenzymes Cause Oxidative Stress under Methylmercury Exposure

(2010) Fusako Usuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of the antifungal and plasma membrane H+-ATPase inhibitory action of ebselen and two ebselen analogs inS. cerevisiaecultures

(2010) Blase Billack et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial

(2010)   LANCET

Adoptive Transfer of Syngeneic Bone Marrow-Derived Cells in Mice with Obesity-Induced Diabetes

(2009) Jun Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Small molecule inhibitors of divalent metal transporter-1

(2009) Peter D. Buckett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Selenazal Drug Ebselen Potently Inhibits Indoleamine 2,3-Dioxygenase by Targeting Enzyme Cysteine Residues

(2009) Andrew C. Terentis et al.   BIOCHEMISTRY

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)

(2009) Rok Sekirnik et al.   CHEMICAL COMMUNICATIONS

The use of ebselen for radioprotection in cultured cells and mice

(2009) Jean Kyoung Tak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells

(2009) Se-Jin Kim et al.   HEARING RESEARCH

Neuroprotection of ebselen against ischemia/reperfusion injury involves GABA shunt enzymes

(2009) Jeong Yeol Seo et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Ebselen Improves Ischemia-Reperfusion Injury After Rat Lung Transplantation

(2009) Jürg Hamacher et al.   LUNG

Growth Inhibitory Action of Ebselen on Fluconazole-Resistant Candida albicans: Role of the Plasma Membrane H+-ATPase

(2009) Blase Billack et al.   Microbial Drug Resistance

Reduction of vesicant toxicity by butylated hydroxyanisole in A-431 skin cells

(2008) Maria A. Pino et al.   Cutaneous and Ocular Toxicology

Ebselen attenuates cyclophosphamide-induced oxidative stress and DNA damage in mice

(2008) D. N. Tripathi et al.   FREE RADICAL RESEARCH

Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFα)-induced apoptosis through two distinct pathways involving NF-κB downregulation and Fas-mediated formation of death inducing signaling complex

(2008) Vivek Sharma et al.   INTERNATIONAL JOURNAL OF CANCER

Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents

(2008) Cinthia M. Mazzanti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Mechanisms of inhibition of zinc-finger transcription factors by selenium compounds ebselen and selenite

(2008) Jason L. Larabee et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ebselen abrogates TNFα induced pro-inflammatory response in glioblastoma

(2008) Richa Tewari et al.   Molecular Oncology

Antioxidant and anti-mutagenic effects of ebselen in yeast and in cultured mammalian V79 cells

(2008) S. T. Miorelli et al.   MUTAGENESIS

Ebselen increases cytosolic free Ca2+ concentration, stimulates glutamate release and increases GFAP content in rat hippocampal astrocytes

(2008) Miguel Salazar et al.   TOXICOLOGY

Ebselen attenuates cadmium-induced testicular damage in mice

(2007) Ana P. Ardais et al.   JOURNAL OF APPLIED TOXICOLOGY