Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics

(2014) Randal J. Kaufman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6  Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

(2014) A. Higa et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel ER Stress-Independent Function of the UPR in Angiogenesis

(2014) Hery Urra et al.   MOLECULAR CELL

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

(2014) Fabiola Osorio et al.   NATURE IMMUNOLOGY

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

TMBIM protein family: ancestral regulators of cell death

(2014) D Rojas-Rivera et al.   ONCOGENE

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

(2014) B. Kharabi Masouleh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis

(2014) J. Groenendyk et al.   Science Signaling

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Addicted to secrete – novel concepts and targets in cancer therapy

(2014) Nicolas Dejeans et al.   TRENDS IN MOLECULAR MEDICINE

When ER stress reaches a dead end

(2013) Hery Urra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IRE 

(2013) O. Pluquet et al.   CANCER RESEARCH

X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic  -Cell Function

(2013) M. Akiyama et al.   DIABETES

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

(2013) Juan Pablo Muñoz et al.   EMBO JOURNAL

Role of the unfolded protein response in organ physiology: Lessons from mouse models

(2013) Víctor Hugo Cornejo et al.   IUBMB LIFE

Interaction of Nck1 and PERK phosphorylated at Y561 negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content

(2013) Lama Yamani et al.   MOLECULAR BIOLOGY OF THE CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis

(2013) Soledad Matus et al.   PLoS One

Negative feedback by IRE1  optimizes mucin production in goblet cells

(2013) A. Tsuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response

(2013) K.-i. Mishiba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-1291-mediated silencing of IRE1  enhances Glypican-3 expression

(2013) M. Maurel et al.   RNA

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

(2012) D Rojas-Rivera et al.   CELL DEATH AND DIFFERENTIATION

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

Nonmuscle Myosin IIB Links Cytoskeleton to IRE1α Signaling during ER Stress

(2012) Yin He et al.   DEVELOPMENTAL CELL

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α

(2012) Diego A Rodriguez et al.   EMBO JOURNAL

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

(2012) Rene L. Vidal et al.   HUMAN MOLECULAR GENETICS

Autocrine control of glioma cells adhesion and migration through IRE1 -mediated cleavage of SPARC mRNA

(2012) N. Dejeans et al.   JOURNAL OF CELL SCIENCE

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

(2012) Kyu Yeon Hur et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

(2012) Masahiro Usui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Comparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells

(2012) Deepika Gaddam et al.   MOLECULAR BIOLOGY OF THE CELL

The ER stress transducer IRE1β is required for airway epithelial mucin production

(2012) M B Martino et al.   Mucosal Immunology

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

(2012) Cécile Guichard et al.   NATURE GENETICS

PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites

(2012) Jürgen Glas et al.   PLoS One

Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β

(2012) Daisuke Oikawa et al.   PLoS One

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

(2012) V Valenzuela et al.   Cell Death & Disease

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

(2012) Mimi A. Trinh et al.   Cell Reports

The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

(2012) Philipp Kimmig et al.   eLife

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

(2011) Maruf M U Ali et al.   EMBO JOURNAL

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

(2011) Roberto Bravo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

(2011) J. Maiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat

(2010) Diego Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells

(2010) Yukio Kimata et al.   CURRENT OPINION IN CELL BIOLOGY

XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum

(2010) Won Jae Huh et al.   GASTROENTEROLOGY

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress

(2010) Juan Rong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2

(2010) Atsushi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

XBP-1 Couples Endoplasmic Reticulum Stress to Augmented IFN-  Induction via a cis-Acting Enhancer in Macrophages

(2010) L. Zeng et al.   JOURNAL OF IMMUNOLOGY

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription

(2010) Q. J. Lew et al.   NUCLEIC ACIDS RESEARCH

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs

(2010) Mariana Bollo et al.   PLoS One

Inositol-requiring enzyme 1  is a key regulator of angiogenesis and invasion in malignant glioma

(2010) G. Auf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak

(2009) Martina Klee et al.   EMBO JOURNAL

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance

(2009) Béatrice Bailly-Maitre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP

(2009) Min Ni et al.   PLoS One

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA

(2008) Jahangir Iqbal et al.   Cell Metabolism

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

RNase domains determine the functional difference between IRE1α and IRE1β

(2008) Yusuke Imagawa et al.   FEBS LETTERS

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation

(2008) Jianwen Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Cytochrome c: functions beyond respiration

(2008) Yong-Ling P. Ow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

(2008) C. Hetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Activating transcription factor 4

(2007) Kurosh Ameri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

(2007) Jennifer N. Gass et al.   MOLECULAR IMMUNOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY