Engineering mammalian cells to seek senescence-associated secretory phenotypes

Novel strategies for anti-aging drug discovery

(2017) Komal Saraswat et al.   Expert Opinion on Drug Discovery

Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6

(2016) Fredrik Anesten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Engineering Synthetic Proteins to Generate Ca2+ Signals in Mammalian Cells

(2016) Anam Qudrat et al.   ACS Synthetic Biology

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells

(2015) Luis Jaime Castro-Vega et al.   CARCINOGENESIS

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2

(2015) S Hubackova et al.   ONCOGENE

IL-6 biology: implications for clinical targeting in rheumatic disease

(2014) Leonard H. Calabrese et al.   Nature Reviews Rheumatology

Light activated cell migration in synthetic extracellular matrices

(2012) Qiongyu Guo et al.   BIOMATERIALS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

An Improved Genetically Encoded Red Fluorescent Ca2+ Indicator for Detecting Optically Evoked Action Potentials

(2012) Masamichi Ohkura et al.   PLoS One

Engineered Networks of Synthetic and Natural Proteins To Control Cell Migration

(2012) Evan Mills et al.   ACS Synthetic Biology

Programming Membrane Fusion and Subsequent Apoptosis into Mammalian Cells

(2012) Seema Nagaraj et al.   ACS Synthetic Biology

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ca2+-Mediated Synthetic Biosystems Offer Protein Design Versatility, Signal Specificity, and Pathway Rewiring

(2011) Evan Mills et al.   CHEMISTRY & BIOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism

(2010) Dervla O'Malley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Characterization of Herpes Simplex Virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity

(2002) Mark S. Kokoris et al.   PROTEIN SCIENCE