KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability

Mechanism of ciliary disassembly

(2016) Yinwen Liang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure–function relationships of human JmjC oxygenases—demethylases versus hydroxylases

(2016) Suzana Markolovic et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53

(2016) S Ramadoss et al.   ONCOGENE

HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

(2016) Damayanti Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival

(2016) Hiroto Ohguchi et al.   Nature Communications

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

(2016) Riina Kaukonen et al.   Nature Communications

Role for the IFT-A Complex in Selective Transport to the Primary Cilium

(2016) Wenxiang Fu et al.   Cell Reports

Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model

(2016) Quan-Yi Zhao et al.   Clinical Epigenetics

A mathematical model explains saturating axon guidance responses to molecular gradients

(2016) Huyen Nguyen et al.   eLife

Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization

(2015) Gil Myoung Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm

(2015) Jovenal T. San Agustin et al.   MOLECULAR BIOLOGY OF THE CELL

The centrosome is an actin-organizing centre

(2015) Francesca Farina et al.   NATURE CELL BIOLOGY

Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

(2015) Philipp Schneider et al.   Nature Communications

JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis

(2015) Yohei Abe et al.   Nature Communications

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

(2015) Jongshin Kim et al.   Nature Communications

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

(2015) Andrew E. Tee et al.   Oncotarget

Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events

(2014) Haguy Wolfenson et al.   BIOPHYSICAL JOURNAL

Actin Is Required for IFT Regulation in Chlamydomonas reinhardtii

(2014) Prachee Avasthi et al.   CURRENT BIOLOGY

Leptin-promoted cilia assembly is critical for normal energy balance

(2014) Yu Mi Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis

(2014) Ioannis Kasioulis et al.   MOLECULAR BIOLOGY OF THE CELL

Capping protein regulators fine-tune actin assembly dynamics

(2014) Marc Edwards et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer

(2014) Mark A. Wade et al.   NUCLEIC ACIDS RESEARCH

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Apical Abscission Alters Cell Polarity and Dismantles the Primary Cilium During Neurogenesis

(2014) R. M. Das et al.   SCIENCE

Specific Phosphorylation of Histone Demethylase KDM3A Determines Target Gene Expression in Response to Heat Shock

(2014) Mo-bin Cheng et al.   PLOS BIOLOGY

Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages

(2013) T. Osawa et al.   CANCER RESEARCH

Small Molecules CK-666 and CK-869 Inhibit Actin-Related Protein 2/3 Complex by Blocking an Activating Conformational Change

(2013) Byron Hetrick et al.   CHEMISTRY & BIOLOGY

Bardet–Biedl syndrome proteins control the cilia length through regulation of actin polymerization

(2013) Victor Hernandez-Hernandez et al.   HUMAN MOLECULAR GENETICS

Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin

(2013) Stefan A. Koestler et al.   MOLECULAR BIOLOGY OF THE CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma

(2013) J K Parrish et al.   ONCOGENE

Protein Complex Interactor Analysis and Differential Activity of KDM3 Subfamily Members Towards H3K9 Methylation

(2013) Michael Brauchle et al.   PLoS One

Evidence for reciliation of RPE1 cells in late G1 phase, and ciliary localisation of cyclin B1

(2013) Cosma Spalluto et al.   FEBS Open Bio

miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics

(2012) Jingli Cao et al.   NATURE CELL BIOLOGY

Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection

(2011) Daisaku Yamada et al.   ANNALS OF SURGICAL ONCOLOGY

The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene

(2011) Hyun-Soo Cho et al.   INTERNATIONAL JOURNAL OF CANCER

Jumonji Domain Containing 1A Is a Novel Prognostic Marker for Colorectal Cancer: In vivo Identification from Hypoxic Tumor Cells

(2010) M. Uemura et al.   CLINICAL CANCER RESEARCH

Histone Demethylase JHDM2A Is Involved in Male Infertility and Obesity

(2010) Y. Okada et al.   JOURNAL OF ANDROLOGY

Cell shape and contractility regulate ciliogenesis in cell cycle–arrested cells

(2010) Amandine Pitaval et al.   JOURNAL OF CELL BIOLOGY

Functional genomic screen for modulators of ciliogenesis and cilium length

(2010) Joon Kim et al.   NATURE

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases

(2009) Jun Yang et al.   Annals of the New York Academy of Sciences

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice

(2009) Takeshi Inagaki et al.   GENES TO CELLS

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

(2009) Keisuke Tateishi et al.   NATURE

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

(2008) Sven Wellmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction

(2008) Gaelle Kustermans et al.   BIOCHEMICAL PHARMACOLOGY

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors

(2008) Nicolas F. Berbari et al.   MOLECULAR BIOLOGY OF THE CELL