Article
Biochemistry & Molecular Biology
Anand Chopra, William G. Willmore, Kyle K. Biggar
Summary: JmjC KDMs are a type of demethylase that not only are associated with histone demethylation, but also with non-histone demethylation. Recent findings have highlighted the importance of KDM3A in promoting cancerous phenotypes, which can provide insights into the mechanisms through which it exerts its oncogenic functions.
Review
Pharmacology & Pharmacy
Chang-Yun Li, Yan-Jun Liu, Fan Tao, Ru-Yi Chen, Jin-Jin Shi, Jian-Fei Lu, Guan -Jun Yang, Jiong Chen
Summary: This article discusses the important role of lysine-specific demethylase 7A (KDM7A) in biological regulation and disease development, as well as its structure, function, and potential drug treatments. KDM7A is not only crucial for normal development but also associated with various diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhenshuo Zhu, Xiaolong Wu, Qun Li, Juqing Zhang, Shuai Yu, Qiaoyan Shen, Zhe Zhou, Qin Pan, Wei Yue, Dezhe Qin, Ying Zhang, Wenxu Zhao, Rui Zhang, Sha Peng, Na Li, Shiqiang Zhang, Anmin Lei, Yi-Liang Miao, Zhonghua Liu, Xingqi Chen, Huayan Wang, Mingzhi Liao, Jinlian Hua
Summary: By culturing piPSCs in different conditions and studying the dynamic changes of H3K9 methylation, the study revealed the critical role of H3K9 demethylases KDM3A and KDM3B in maintaining the pluripotency of piPSCs. It was also found that OCT4 and SOX2 cooperate with KDM3A and KDM3B to promote pluripotency gene expression, thus sustaining the pluripotent state of piPSCs.
Article
Biochemistry & Molecular Biology
Jian-Cheng Wu, Jie Sun, Jia-Cheng Xu, Zhen-Yu Zhou, Ya-Feng Zhang
Summary: This study investigated the impact of miR-199a-3p on osteoporosis and its underlying mechanism. MiR-199a-3p negatively regulated MSC differentiation, with increased expression in OVX rats inhibiting osteogenic differentiation. Kdm3a was targeted negatively by miR-199a-3p, and it promoted osteogenic differentiation by enhancing Erk2 and Klf2 demethylation.
BIOCHEMICAL JOURNAL
(2021)
Review
Chemistry, Medicinal
Yihui Song, Huiqing Zhang, Xiaoke Yang, Yuting Shi, Bin Yu
Summary: Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising epigenetic target for disease treatment. This review provides an update on LSD1 inhibitors, including natural products, synthetic compounds, and cyclic peptides reported in 2021. The design strategies, structure-activity relationships, binding model analysis, and modes of action are discussed. Highlights include the repurposing of FDA-approved drugs as reversible LSD1 inhibitors, the identification of clinical candidates for neuro-developmental disorders, and the enhanced anti-cancer effects of dual inhibitors targeting both LSD1 and HDAC6 or tubulin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Hua Zhang, Yanfang Wang, Xiaolei Bian, Hang Yin
Summary: This study revealed that miR-194 inhibits the development of abdominal aortic aneurysm by suppressing BNIP3 expression mediated by KDM3A. This finding provides a new target for the treatment of AAA.
Article
Biochemistry & Molecular Biology
Chunling Ren, Yaolan Lin, Xiaoqin Liu, Dan Yan, Xiao Xu, Dongrong Zhu, Lingyi Kong, Chao Han
Summary: The study isolated four sesquiterpene-based LSD1 inhibitors from zedoary turmeric oil using target separation countercurrent chromatography technique, demonstrating their potential anti-tumor activity.
BIOORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Bofang Zhang, Gen Liu, Bing Huang, Huafen Liu, Hong Jiang, Zheng Hu, Jing Chen
Summary: This study demonstrates the important role of KDM3A in cardiac microvascular endothelial cell injury during hypoxia/reoxygenation. KDM3A knockout exacerbates CMEC dysfunction and pyroptosis, while its overexpression ameliorates these injuries. Mechanistically, KDM3A activates the PI3K/Akt signaling pathway to protect against CMEC pyroptosis. These findings suggest that KDM3A is a promising therapeutic target for alleviating CMEC ischemia-reperfusion injury.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Lokha R. Alagar Boopathy, Emma Beadle, Alan RuoChen Xiao, Aitana Garcia-Bueno Rico, Celia Alecki, Irene Garcia de-Andres, Kyla Edelmeier, Luca Lazzari, Mehdi Amiri, Maria Vera
Summary: Cells survive harsh conditions by upregulating heat shock proteins (HSPs), specifically HSP70 family. The HSP70 mRNA is translated during stress and rapidly degraded upon recovery. Contrary to its untranslated region, the coding sequence (CDS) of HSP70 suppresses its translation via ribosome quality control (RQC) mechanism. RQC recognizes stalled ribosomes and destabilizes the mRNA, regulating HSP70 synthesis.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Shojiro Kitajima, Wendi Sun, Kian Leong Lee, Jolene Caifeng Ho, Seiichi Oyadomari, Takashi Okamoto, Hisao Masai, Lorenz Poellinger, Hiroyuki Kato
Summary: The UTX/KDM6A gene encodes a major histone H3 lysine 27 (H3K27) demethylase and is frequently mutated in human cancers. The pharmacological inhibitor GSK-J4 induces the expression of ATF4 protein and its target genes. The inhibition of UTX partially leads to ATF4 induction, suggesting a potential role of UTX in regulating cancer formation through the HRI-ATF4 axis.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Fangjing Ni, Heting Tang, Siteng Cheng, Yaoyu Yu, Zhihao Yuan, Yingfei Chen, Encheng Zhang, Xiang Wang
Summary: This review provides a comprehensive examination of the structure, mechanism, and function of KDM4B, as well as a critical analysis of its involvement in tumorigenesis and development. It also explores potential therapeutic strategies that specifically target KDM4B.
Review
Integrative & Complementary Medicine
Li Zhong-Rui, Gu Meng-Zhen, Xu Xiao, Zhang Jing-Han, Zhang Hai-Li, Han Chao
Summary: This review highlights recent advances in natural LSD1 inhibitors, including their discovery and identification process, natural sources, chemical structures, anticancer effects, and structure-activity relationships. Natural products play an important role in drug discovery, particularly in cancer therapy.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Cell Biology
Laura Virtanen, Emilia Holm, Mona Halme, Gun West, Fanny Lindholm, Josef Gullmets, Juho Irjala, Tiina Helio, Artur Padzik, Annika Meinander, John E. Eriksson, Pekka Taimen
Summary: The heat shock response is crucial for cell survival in harmful environments. This study found that lamin A/C, encoded by the LMNA gene, is reversibly phosphorylated at serine 22 upon heat shock, facilitating nucleoplasmic localization and nuclear shape changes. This phosphorylation stoichiometry of lamin A/C plays a conserved role in regulating lamina structure and promoting cell survival during heat shock.
JOURNAL OF CELL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Dongha Kim, Hye Jin Nam, Sung Hee Baek
Summary: Lysine-specific demethylase 1 (LSD1) plays a crucial role in regulating gene expression through its catalytic activity and interactions with various protein partners. The function of LSD1 is tightly regulated by diverse post-translational modifications (PTMs). This review provides a comprehensive understanding of the regulation and function of LSD1 following various PTMs and discusses the therapeutic implications of targeting these modifications for human diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Review
Cardiac & Cardiovascular Systems
Yifei Zou, Henghe Shi, Ning Liu, He Wang, Xianjing Song, Bin Liu
Summary: Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in various cellular stress states and plays a crucial role in regulating proteostasis and cellular response to stress. It has been extensively studied in cardiovascular diseases, where it is involved in oxidative stress, inflammatory responses, apoptosis, and potentially serves as a diagnostic and therapeutic target. Targeting HSP27 shows promise for the treatment of cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gui-fen Liu, Jian-yi Lu, Yan-jun Zhang, Lang-xi Zhang, Guo-dong Lu, Ze-jun Xie, Mo-bin Cheng, Yu-fei Shen, Ye Zhang
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2016)
Article
Biochemistry & Molecular Biology
C. Cao, S. N. Vasilatos, R. Bhargava, J. L. Fine, S. Oesterreich, N. E. Davidson, Y. Huang
Article
Oncology
Jian-lin Yang, Ye Qin, Liang Li, Chu-yu Cao, Qing Wang, Qian Li, Ya-feng Lv, Yanlin Wang
Article
Oncology
Lin Chen, Shauna N. Vasilatos, Ye Qin, Tiffany A. Katz, Chunyu Cao, Hao Wu, Nilgun Tasdemir, Kevin M. Levine, Steffi Oesterreich, Nancy E. Davidson, Yi Huang
Article
Oncology
Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen, Ye Zhang
Review
Biotechnology & Applied Microbiology
Hong-yan Wu, Chun-yu Cao
BRIEFINGS IN FUNCTIONAL GENOMICS
(2019)
Article
Oncology
Chunyu Cao, Hao Wu, Shauna N. Vasilatos, Uma Chandran, Ye Qin, Yong Wan, Steffi Oesterreich, Nancy E. Davidson, Yi Huang
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Medicine, Research & Experimental
Fan Yang, Faling Wang, Yuni Liu, Shien Wang, Xin Li, Yi Huang, Yan Xia, Chunyu Cao
Article
Oncology
Li-Ming Liu, Wen-Zheng Sun, Xue-Zhe Fan, Ya-Li Xu, Mo-Bin Cheng, Ye Zhang
Article
Biochemistry & Molecular Biology
Qi Liu, Xin-ling Zhang, Mo-bin Cheng, Ye Zhang
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2019)
Letter
Cell & Tissue Engineering
Mo-bin Cheng, Xue Wang, Yue Huang, Ye Zhang
STEM CELL RESEARCH & THERAPY
(2020)
Article
Cell & Tissue Engineering
Wei Wang, Ya-feng Lv, Yan-jun Zhang, Wen-ji Dong, Ye Zhang
STEM CELL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Zhen-yu Zuo, Guang-hui Yang, Hai-yu Wang, Shu-yu Liu, Yan-jun Zhang, Yun Cai, Fei Chen, Hui Dai, Yi Xiao, Mo-bin Cheng, Yue Huang, Ye Zhang
Summary: This study reveals the important regulatory role of Prmt1 in the formation of primitive endoderm (PrE). Prmt1 depletion promotes the expression of PrE genes and increases the efficiency of induction of extraembryonic endoderm stem cells. Furthermore, the study shows that Prmt1-mediated methylation of Klf4 is required for the repression of PrE genes, and inhibition of Prmt1 and mutation of Klf4 can induce the integration of mouse embryonic stem cells into the PrE lineage.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mei Li, Jing Wang, Fenfen Wang, Padraig Strappe, Wenting Liu, Jianxian Zheng, Zhongkai Zhou, Ye Zhang
Summary: Starches acylated with specific short-chain fatty acids have the potential to provide specificity in SCFA delivery. Fermentation of these acylated starches in the gut microbiota specifically increased the production of corresponding SCFAs, indicating effective release of the introduced acyl group. Furthermore, utilization of these starches generated more total SCFAs and can be effectively fermented by the microbiota as a carbohydrate substrate.
Article
Biochemistry & Molecular Biology
Hai-xia Yan, Yan-jun Zhang, Yuan Zhang, Xue Ren, Yu-fei Shen, Mo-bin Cheng, Ye Zhang
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2017)