The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma

The Role of miRNAs in Regulating Gene Expression Networks

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Epigenetic Changes in Pediatric Solid Tumors: Promising New Targets

(2012) E. R. Lawlor et al.   CLINICAL CANCER RESEARCH

Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A

(2012) I. Mimura et al.   MOLECULAR AND CELLULAR BIOLOGY

Restoration of miR-200c to Ovarian Cancer Reduces Tumor Burden and Increases Sensitivity to Paclitaxel

(2012) D. M. Cittelly et al.   MOLECULAR CANCER THERAPEUTICS

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

MiR-30a-5p connects EWS-FLI1 and CD99, two major therapeutic targets in Ewing tumor

(2012) G-A Franzetti et al.   ONCOGENE

Genetic Events That Shape the Cancer Epigenome

(2012) R. J. H. Ryan et al.   SCIENCE

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription

(2011) M. Patel et al.   GENOME RESEARCH

The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene

(2011) Hyun-Soo Cho et al.   INTERNATIONAL JOURNAL OF CANCER

miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

(2011) Fumihiko Nakatani et al.   JOURNAL OF PATHOLOGY

Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening

(2011) Patrick J. Grohar et al.   JNCI-Journal of the National Cancer Institute

Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells

(2011) Jian Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma

(2011) J Ban et al.   ONCOGENE

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs

(2011) E L McKinsey et al.   ONCOGENE

Targeting the epigenome for treatment of cancer

(2011) E-J Geutjes et al.   ONCOGENE

Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development

(2011) Claudio De Vito et al.   PLoS One

Differentiation-associated miR-22 represses Max expression and inhibits cell cycle progression

(2010) Yi Ting et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

(2010) J Zhang et al.   BRITISH JOURNAL OF CANCER

Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells

(2010) Haobin Chen et al.   CARCINOGENESIS

Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future

(2010) Joseph A Ludwig   CURRENT OPINION IN ONCOLOGY

An estrogen receptor α suppressor, microRNA-22, is downregulated in estrogen receptor α-positive human breast cancer cell lines and clinical samples

(2010) Jianhua Xiong et al.   FEBS Journal

An inhibitory effect of miR-22 on cell migration and invasion in ovarian cancer

(2010) Jun Li et al.   GYNECOLOGIC ONCOLOGY

A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer

(2010) Ankur K. Nagaraja et al.   MOLECULAR ENDOCRINOLOGY

Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein

(2010) J Xiong et al.   ONCOGENE

Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22

(2010) J B Patel et al.   ONCOGENE

Recent advances in the molecular pathogenesis of Ewing's sarcoma

(2010) E C Toomey et al.   ONCOGENE

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

(2009) G. H. S. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell

(2009) G. Sotiropoulou et al.   RNA

BMI-1 Promotes Ewing Sarcoma Tumorigenicity Independent of CDKN2A Repression

(2008) D. Douglas et al.   CANCER RESEARCH

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

A Jumonji (Jarid2) Protein Complex Repressescyclin D1Expression by Methylation of Histone H3-K9

(2008) Haruki Shirato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY