Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome

(2015) Emily L. Putiri et al.   Oncotarget

Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer

(2014) L Chen et al.   BRITISH JOURNAL OF CANCER

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Identification of functional cooperative mutations of SETD2 in human acute leukemia

(2014) Xiaofan Zhu et al.   NATURE GENETICS

The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer

(2014) Mark A. Wade et al.   NUCLEIC ACIDS RESEARCH

Epigenetic targets and drug discovery

(2014) Yanli Liu et al.   PHARMACOLOGY & THERAPEUTICS

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

(2014) Sílvia Carvalho et al.   eLife

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

(2013) Adam M. Fontebasso et al.   ACTA NEUROPATHOLOGICA

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors

(2013) Joshua C. Black et al.   CELL

Aberrant promoter hypermethylation ofPBRM1,BAP1,SETD2,KDM6Aand other chromatin-modifying genes is absent or rare in clear cell RCC

(2013) Ilsiya Ibragimova et al.   Epigenetics

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model

(2013) F. Danielsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Regulation of Mouse Sex Determination by the Histone Demethylase Jmjd1a

(2013) S. Kuroki et al.   SCIENCE

SET for life: biochemical activities and biological functions of SET domain-containing proteins

(2013) Hans-Martin Herz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

(2013) James P Reddington et al.   GENOME BIOLOGY

The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression

(2012) Leah C. Young et al.   Biochemistry and Cell Biology

MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB

(2012) Xiang Wang et al.   JOURNAL OF CELL SCIENCE

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

JMJD2A Promotes Cellular Transformation by Blocking Cellular Senescence through Transcriptional Repression of the Tumor Suppressor CHD5

(2012) Frédérick A. Mallette et al.   Cell Reports

Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway

(2012) Quanyi Zhao et al.   SpringerPlus

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Global Levels of Histone Modifications Predict Prognosis in Different Cancers

(2009) David B. Seligson et al.   AMERICAN JOURNAL OF PATHOLOGY

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

(2009) Chongzhi Zang et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

(2009) S. E. Elsheikh et al.   CANCER RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1  Enhances Hypoxic Gene Expression and Tumor Growth

(2009) A. J. Krieg et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetics in cancer: Targeting chromatin modifications

(2009) L. Ellis et al.   MOLECULAR CANCER THERAPEUTICS

Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells

(2009) Bo Wen et al.   NATURE GENETICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE