Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer

Activation of toll-like receptor signaling pathways leading to nitric oxide-mediated antiviral responses

(2016) Mohamed Sarjoon Abdul-Cader et al.   ARCHIVES OF VIROLOGY

Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model

(2015) Hiroyasu Ito et al.   IMMUNOLOGY

New TLR7 agonists with improved humoral and cellular immune responses

(2015) Katherine C. Upchurch et al.   IMMUNOLOGY LETTERS

Dendritic Cell–Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma

(2015) Mahua Dey et al.   JOURNAL OF IMMUNOLOGY

Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus

(2015) D. Ramírez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dendritic-cell vaccines on the move

(2015) Rachel Lubong Sabado et al.   NATURE

Prophylactic Dendritic Cell-Based Vaccines Efficiently Inhibit Metastases in Murine Metastatic Melanoma

(2015) Oleg V. Markov et al.   PLoS One

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

(2015) Michael Platten et al.   Frontiers in Immunology

Dendritic Cell-Based Vaccination in Cancer: Therapeutic Implications Emerging from Murine Models

(2015) Soledad Mac Keon et al.   Frontiers in Immunology

PyNTTTTGT and CpG Immunostimulatory Oligonucleotides: Effect on Granulocyte/Monocyte Colony-Stimulating Factor (GM-CSF) Secretion by Human CD56+ (NK and NKT) Cells

(2015) Juan M. Rodriguez et al.   PLoS One

Nitric Oxide Sustains IL-1β Expression in Human Dendritic Cells Enhancing Their Capacity to Induce IL-17–Producing T-Cells

(2015) Carolina Obregon et al.   PLoS One

Plasmacytoid Dendritic Cells in the Tumor Microenvironment: Immune Targets for Glioma Therapeutics

(2015) Marianela Candolfi et al.   NEOPLASIA

Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells

(2014) Liana Verinaud et al.   Cellular & Molecular Immunology

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration

(2014) Karen Rosenberger et al.   Journal of Neuroinflammation

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

(2014) Julia Scheiermann et al.   VACCINE

Vaccines for Cancer Prevention: A Practical and Feasible Approach to the Cancer Epidemic

(2014) O. J. Finn   Cancer Immunology Research

Tolerogenic Splenic IDO+Dendritic Cells from the Mice Treated with Induced-Treg Cells Suppress Collagen-Induced Arthritis

(2014) Jie Yang et al.   Journal of Immunology Research

Combination therapy targeting toll like receptors 7, 8 and 9 eliminates large established tumors

(2014) By Zhao et al.   Journal for ImmunoTherapy of Cancer

In vitro and in vivo evaluations of human papillomavirus type 16 (HPV16)-derived peptide-loaded dendritic cells (DCs) with a CpG oligodeoxynucleotide (CpG-ODN) adjuvant as tumor vaccines for immunotherapy of cervical cancer

(2013) Hua Li Wang et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

CD141+ dendritic cells produce prominent amounts of IFN-  after dsRNA recognition and can be targeted via DEC-205 in humanized mice

(2013) S. Meixlsperger et al.   BLOOD

Combinations of TLR Ligands: A Promising Approach in Cancer Immunotherapy

(2013) Saskia Stier et al.   Clinical & Developmental Immunology

The use of Toll-like receptor 7/8 agonists as vaccine adjuvants

(2013) John P Vasilakos et al.   Expert Review of Vaccines

Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients

(2013) MOULDY SIOUD et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness

(2013) Caroline Hémont et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

NF-κB activation during intradermal DNA vaccination is essential for eliciting tumor protective antigen-specific CTL responses

(2013) Maarten A Ligtenberg et al.   Human Vaccines & Immunotherapeutics

Differential Expression of Toll-like Receptors in Dendritic Cells of Patients with Dengue during Early and Late Acute Phases of the Disease

(2013) Silvia Torres et al.   PLoS Neglected Tropical Diseases

A distinct tolerogenic subset of splenic IDO+CD11b+ dendritic cells from orally tolerized mice is responsible for induction of systemic immune tolerance and suppression of collagen-induced arthritis

(2012) Min-Jung Park et al.   CELLULAR IMMUNOLOGY

Molecular Pathways: Toll-like Receptors in the Tumor Microenvironment--Poor Prognosis or New Therapeutic Opportunity

(2012) L. A. Ridnour et al.   CLINICAL CANCER RESEARCH

Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model

(2012) Xiufen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

Dendritic Cell-Specific Transcript: Dendritic Cell Marker and Regulator of TLR-Induced Cytokine Production

(2012) S. Hontelez et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 7 agonist, Imiquimod, inhibits oral squamous carcinoma cells through apoptosis and necrosis

(2012) Mee-Young Ahn et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28

(2011) J. S. Pufnock et al.   BLOOD

Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance

(2011) C. Bourquin et al.   CANCER RESEARCH

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

CpG DNA as a vaccine adjuvant

(2011) Christian Bode et al.   Expert Review of Vaccines

A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy

(2011) Priyadharshini Narayanan et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer

(2011) Rui Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Physiologic Control of IDO Competence in Splenic Dendritic Cells

(2011) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Phase I clinical trial of CpG oligonucleotide 7909 (PF-03512676) in patients with previously treated chronic lymphocytic leukemia

(2011) Clive S. Zent et al.   LEUKEMIA & LYMPHOMA

IL-10 expression by primary tumor cells correlates with melanoma progression from radial to vertical growth phase and development of metastatic competence

(2011) Eijun Itakura et al.   MODERN PATHOLOGY

Co-stimulation with TLR7/8 and TLR9 agonists induce down-regulation of innate immune responses in sheep blood mononuclear and B cells

(2010) Jayaum S. Booth et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Neuronal Nitric Oxide Synthase Modulates Maturation of Human Dendritic Cells

(2010) H. S. Adler et al.   JOURNAL OF IMMUNOLOGY

Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis

(2010) M. A. Ciorba et al.   JOURNAL OF IMMUNOLOGY

Dual Stimulation of MyD88‐Dependent Toll‐Like Receptors Induces Synergistically Enhanced Production of Inflammatory Cytokines in Murine Bone Marrow–Derived Dendritic Cells

(2010) Daniel Mitchell et al.   JOURNAL OF INFECTIOUS DISEASES

Human Flt3L Generates Dendritic Cells from Canine Peripheral Blood Precursors: Implications for a Dog Glioma Clinical Trial

(2010) Weidong Xiong et al.   PLoS One

Mature dendritic cells use endocytic receptors to capture and present antigens

(2010) C. D. Platt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer

(2010) Ivan Hirsch et al.   TRENDS IN IMMUNOLOGY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia

(2009) Niranjan B. Butchi et al.   GLIA

Human Dendritic Cells Stimulated via TLR7 and/or TLR8 Induce the Sequential Production of Il-10, IFN- , and IL-17A by Naive CD4+ T Cells

(2009) V. Lombardi et al.   JOURNAL OF IMMUNOLOGY

TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation

(2009) A. Larange et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites

(2008) R. T. Semnani et al.   BLOOD

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC- -dependent mechanism

(2008) A. Paone et al.   CARCINOGENESIS

Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

(2008) A M Krieg   ONCOGENE

TLR signaling by tumor and immune cells: a double-edged sword

(2008) B Huang et al.   ONCOGENE

TLR7 and TLR8 as targets in cancer therapy

(2008) M P Schön et al.   ONCOGENE

The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy

(2008) E. L. J. M. Smits et al.   ONCOLOGIST

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

(2008) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA