Glycation of Lys-16 and Arg-5 in amyloid-β and the presence of Cu2+ play a major role in the oxidative stress mechanism of Alzheimer’s disease

Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides

(2017) Jeffrey S. Derrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

(2017) Clémence Cheignon et al.   Chemical Science

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1–42 Aggregation

(2016) Ke Sherry Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the generation of OH· radical species from H2O2 by Cu(I) amyloid beta peptide model complexes: a DFT investigation

(2015) Tommaso Prosdocimi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Dioxygen activation in the Cu–amyloid β complex

(2015) Andrea Mirats et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Arginine: Its pKavalue revisited

(2015) Carolyn A. Fitch et al.   PROTEIN SCIENCE

β-Amyloid Fibrils in Alzheimer Disease Are Not Inert When Bound to Copper Ions but Can Degrade Hydrogen Peroxide and Generate Reactive Oxygen Species

(2014) Jennifer Mayes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Methylglyoxal in Alzheimer’s Disease

(2014) Cristina Angeloni et al.   Biomed Research International

Arginine Modifications by Methylglyoxal: Discovery in a Recombinant Monoclonal Antibody and Contribution to Acidic Species

(2013) Chris Chumsae et al.   ANALYTICAL CHEMISTRY

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

(2013) Elsa Suberbielle et al.   NATURE NEUROSCIENCE

Heme prevents amyloid beta peptide aggregation through hydrophobic interaction based on molecular dynamics simulation

(2013) Li Na Zhao et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Glycation exacerbates the neuronal toxicity of β-amyloid

(2013) X-H Li et al.   Cell Death & Disease

Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

(2012) Gözde Eskici et al.   BIOCHEMISTRY

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

Bioinorganic Chemistry of Alzheimer’s Disease

(2012) Kasper P. Kepp   CHEMICAL REVIEWS

Werner coordination chemistry and neurodegeneration

(2012) Maria A. Telpoukhovskaia et al.   CHEMICAL SOCIETY REVIEWS

Large shifts in pKa values of lysine residues buried inside a protein

(2011) D. G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maillard reaction of ribose 5-phosphate generates superoxide and glycation products for bovine heart cytochrome c reduction

(2010) Rebecca A. Gersten et al.   CARBOHYDRATE RESEARCH

Ternary Complexes of Iron, Amyloid-β, and Nitrilotriacetic Acid: Binding Affinities, Redox Properties, and Relevance to Iron-Induced Oxidative Stress in Alzheimer’s Disease

(2009) Dianlu Jiang et al.   BIOCHEMISTRY

Reevaluation of the 2-deoxyribose assay for determination of free radical formation

(2009) Thiago C. Genaro-Mattos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The chemistry of Alzheimer’s disease

(2009) Arvi Rauk   CHEMICAL SOCIETY REVIEWS

Comparative Molecular Dynamics Studies of Wild-Type and Oxidized Forms of Full-Length Alzheimer Amyloid β-Peptides Aβ(1−40) and Aβ(1−42)

(2008) Luciano Triguero et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Amyloid-β Peptide of Alzheimer’s Disease Binds CuIin a Linear Bis-His Coordination Environment: Insight into a Possible Neuroprotective Mechanism for the Amyloid-β Peptide

(2008) Jason Shearer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY