Werner coordination chemistry and neurodegeneration

Interactions of Cu2+ with prion family peptide fragments: Considerations on affinity, speciation and coordination

(2012) Giuseppe Arena et al.   COORDINATION CHEMISTRY REVIEWS

Affinity of copper and zinc ions to proteins and peptides related to neurodegenerative conditions (Aβ, APP, α-synuclein, PrP)

(2012) Izabela Zawisza et al.   COORDINATION CHEMISTRY REVIEWS

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

(2012) Andrés Binolfi et al.   COORDINATION CHEMISTRY REVIEWS

The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

(2012) Cristina Rodríguez-Rodríguez et al.   COORDINATION CHEMISTRY REVIEWS

Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species

(2012) Xiaoming He et al.   DALTON TRANSACTIONS

Metal Binding Dictates Conformation and Function of the Amyloid Precursor Protein (APP) E2 Domain

(2012) Sven O. Dahms et al.   JOURNAL OF MOLECULAR BIOLOGY

Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42 Peptide

(2012) Anuj K. Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Myricetin: A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity

(2011) Alaina S. DeToma et al.   CHEMBIOCHEM

The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers

(2011) Yong Zhang et al.   DALTON TRANSACTIONS

Exploring the Reactions of β-Amyloid (Aβ) Peptide 1–28 with AlIIIand FeIIIIons

(2011) Daniela Valensin et al.   INORGANIC CHEMISTRY

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

The role of His-50 of α-synuclein in binding Cu(ii): pH dependence, speciation, thermodynamics and structure

(2011) Daniela Valensin et al.   Metallomics

Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126

(2011) Masahiro Kawahara et al.   Metallomics

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Hydroxyquinoline based binders: Promising ligands for chelatotherapy?

(2010) Ana Budimir et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Prochelator Activated by β-Secretase Inhibits Aβ Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

(2010) Drew S. Folk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Aryl-substituted 3-(β-D-glucopyranosyloxy)-2-methyl-4(1H)-pyridinones as agents for Alzheimer's therapy

(2010) Lauren E. Scott et al.   Chemical Science

Pulse EPR Spectroscopy Reveals the Coordination Sphere of Copper(II) Ions in the 1–16 Amyloid-β Peptide: A Key Role of the First Two N-Terminus Residues

(2009) Pierre Dorlet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease

(2009) Lauren E. Scott et al.   CHEMICAL REVIEWS

Two pyridine derivatives as potential Cu(ii) and Zn(ii) chelators in therapy for Alzheimer's disease

(2009) Andrea Lakatos et al.   DALTON TRANSACTIONS

Identification of the Minimal Copper(II)-Binding α-Synuclein Sequence

(2009) Mark S. Jackson et al.   INORGANIC CHEMISTRY

Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid β-Peptide Aggregation and Neurotoxicity

(2009) Tingting Chen et al.   INORGANIC CHEMISTRY

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-β complexes

(2009) Christelle Hureau et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A Cysteine-Based Tripodal Chelator with a High Affinity and Selectivity for Copper(I)

(2009) Anaïs M. Pujol et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pleomorphic Copper Coordination by Alzheimer’s Disease Amyloid-β Peptide

(2009) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alanine-2 Carbonyl is an Oxygen Ligand in Cu2+Coordination of Alzheimer’s Disease Amyloid-β Peptide − Relevance to N-Terminally Truncated Forms

(2009) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease

(2009) Cristina Rodríguez-Rodríguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CuII binding sites located at His-96 and His-111 of the human prion protein: thermodynamic and spectroscopic studies on model peptides

(2008) Ewa Gralka et al.   DALTON TRANSACTIONS

Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides

(2008) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Potentiometric, spectrophotometric and calorimetric study on iron(III) and copper(II) complexes with 1,2-dimethyl-3-hydroxy-4-pyridinone

(2007) Valeria M. Nurchi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

NMR Studies of the Zn2+Interactions with Rat and Human β-Amyloid (1−28) Peptides in Water-Micelle Environment

(2007) Elena Gaggelli et al.   JOURNAL OF PHYSICAL CHEMISTRY B