Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons

(2012) Emmanuel Thomas et al.   GASTROENTEROLOGY

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

(2011) Svetlana Marukian et al.   HEPATOLOGY

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Innate immunity and adjuvants

(2011) S. Akira   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Expression of Type III Interferon (IFN) in the Vaginal Mucosa Is Mediated Primarily by Dendritic Cells and Displays Stronger Dependence on NF- B than Type I IFNs

(2010) M. B. Iversen et al.   JOURNAL OF VIROLOGY

Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system

(2009) Pantxika Bellecave et al.   HEPATOLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

RNA recognition and signal transduction by RIG-I-like receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNOLOGICAL REVIEWS

Interferon-λ Contributes to Innate Immunity of Mice against Influenza A Virus but Not against Hepatotropic Viruses

(2008) Markus Mordstein et al.   PLoS Pathogens