Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM)

(2016) Andrew N. Lane et al.   Metabolomics

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Applications of NMR spectroscopy to systems biochemistry

(2016) Teresa W.-M. Fan et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

(2016) Naniye Mallı Cetinbas et al.   Scientific Reports

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

(2015) Brandon N. Nicolay et al.   GENES & DEVELOPMENT

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

(2015) Neetu Saxena et al.   JNCI-Journal of the National Cancer Institute

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

(2015) Emma E. Vincent et al.   MOLECULAR CELL

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

(2015) Simone Cardaci et al.   NATURE CELL BIOLOGY

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

(2015) Neetu Saxena et al.   JNCI-Journal of the National Cancer Institute

Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells

(2015) Laura Brunelli et al.   Oncotarget

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Glycolysis and the Pentose Phosphate Pathway after Human Traumatic Brain Injury: Microdialysis Studies Using 1,2-13C2 Glucose

(2014) Ibrahim Jalloh et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A metabolomics approach for predicting the response to neoadjuvant chemotherapy in cervical cancer patients

(2014) Yan Hou et al.   Molecular BioSystems

PCK2 activation mediates an adaptive response to glucose depletion in lung cancer

(2014) K Leithner et al.   ONCOGENE

Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase

(2014) Jose L. Izquierdo-Garcia et al.   PLoS One

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

(2013) Paulo A. Gameiro et al.   Cell Metabolism

Loss of RBF1 changes glutamine catabolism

(2013) B. N. Nicolay et al.   GENES & DEVELOPMENT

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Control of glutamine metabolism by the tumor suppressor Rb

(2013) M R Reynolds et al.   ONCOGENE

Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma

(2013) Youfeng Yang et al.   PLoS One

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

Rational design of 13C-labeling experiments for metabolic flux analysis in mammalian cells

(2012) Scott B Crown et al.   BMC Systems Biology

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

(2012) Jenson Qi et al.   JOURNAL OF LIPID RESEARCH

Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer

(2012) Siwei Wei et al.   Molecular Oncology

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on 13C mass isotopologue profiles under non-steady-state conditions

(2011) Hunter NB Moseley et al.   BMC BIOLOGY

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression

(2011) Simon Hu et al.   Cell Metabolism

NMR-based stable isotope resolved metabolomics in systems biochemistry

(2011) Teresa W-M. Fan et al.   JOURNAL OF BIOMOLECULAR NMR

High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS

(2011) Pawel Lorkiewicz et al.   Metabolomics

Stable isotope resolved metabolomics analysis of ribonucleotide and RNA metabolism in human lung cancer cells

(2011) Teresa W-M. Fan et al.   Metabolomics

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Stable isotope-resolved metabolomics and applications for drug development

(2011) Teresa W.-M. Fan et al.   PHARMACOLOGY & THERAPEUTICS

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nontargeted Elucidation of Metabolic Pathways Using Stable-Isotope Tracers and Mass Spectrometry

(2010) Karsten Hiller et al.   ANALYTICAL CHEMISTRY

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

(2010) Saroj P. Mathupala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions

(2010) Teresa W.-M. Fan et al.   Metabolomics

Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR

(2009) Andrew N. Lane et al.   ANALYTICA CHIMICA ACTA

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells

(2009) Jelena Klawitter et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

(2009) Christian M. Metallo et al.   JOURNAL OF BIOTECHNOLOGY

Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)

(2009) Teresa WM Fan et al.   Molecular Cancer

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Structure-based profiling of metabolites and isotopomers by NMR

(2007) Teresa W.-M. Fan et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY