Colibactin: understanding an elusive gut bacterial genotoxin

Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

(2015) Zhong-Rui Li et al.   CHEMBIOCHEM

Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor

(2015) A. O. Brachmann et al.   CHEMICAL COMMUNICATIONS

Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria

(2015) Antony Cougnoux et al.   GUT

Oral Tolerance Failure upon Neonatal Gut Colonization with Escherichia coli Producing the Genotoxin Colibactin

(2015) Thomas Secher et al.   INFECTION AND IMMUNITY

The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic Infection

(2015) Alex J. McCarthy et al.   INFECTION AND IMMUNITY

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

(2015) Carolyn A. Brotherton et al.   ORGANIC LETTERS

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety

(2015) Xiaoying Bian et al.   Chemical Science

Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways

(2014) Philipp Engel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics

(2014) Mohamed S. Donia et al.   CELL

Specialized Metabolites from the Microbiome in Health and Disease

(2014) Gil Sharon et al.   Cell Metabolism

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

The Genotoxin Colibactin Exacerbates Lymphopenia and Decreases Survival Rate in Mice Infected With Septicemic Escherichia coli

(2014) I. Marcq et al.   JOURNAL OF INFECTIOUS DISEASES

The Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity

(2014) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

(2014) Maria I. Vizcaino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microbiology: Microbiome science needs a healthy dose of scepticism

(2014) William P. Hanage   NATURE

Human and Plant Fungal Pathogens: The Role of Secondary Metabolites

(2014) Daniel H. Scharf et al.   PLoS Pathogens

Screening metatranscriptomes for toxin genes as functional drivers of human colorectal cancer

(2013) Bas E. Dutilh et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

(2013) Xiaoying Bian et al.   CHEMBIOCHEM

The genusPseudovibriocontains metabolically versatile bacteria adapted for symbiosis

(2013) Vladimir Bondarev et al.   ENVIRONMENTAL MICROBIOLOGY

A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

(2013) Carolyn A. Brotherton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides

(2013) Daniela Reimer et al.   NATURAL PRODUCT REPORTS

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

(2013) Emmanuel Buc et al.   PLoS One

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

(2013) Thomas Secher et al.   PLoS One

Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli

(2013) Patricia Martin et al.   PLoS Pathogens

Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents

(2012) Marina Tanasova et al.   CHEMICAL REVIEWS

Analysis of Structure–Function Relationships in the Colibactin-Maturating Enzyme ClbP

(2012) Antony Cougnoux et al.   JOURNAL OF MOLECULAR BIOLOGY

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

ClbP Is a Prototype of a Peptidase Subgroup Involved in Biosynthesis of Nonribosomal Peptides

(2011) Damien Dubois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A natural prodrug activation mechanism in nonribosomal peptide synthesis

(2011) Daniela Reimer et al.   Nature Chemical Biology

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Type of Pyrrolidine Biosynthesis Is Involved in the Late Steps of Xenocoumacin Production inXenorhabdus nematophila

(2009) Daniela Reimer et al.   CHEMBIOCHEM

Chemical and Biological Explorations of the Family of CC-1065 and the Duocarmycin Natural Products

(2009) Nandita Ghosh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

(2009) J. Putze et al.   INFECTION AND IMMUNITY

Characterization of the Complete Zwittermicin A Biosynthesis Gene Cluster from Bacillus cereus

(2008) B. M. Kevany et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Molecular Epidemiology and Phylogenetic Distribution of the Escherichia coli pks Genomic Island

(2008) J. R. Johnson et al.   JOURNAL OF CLINICAL MICROBIOLOGY