Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling

Role of TGF Beta and PPAR Alpha Signaling Pathways in Radiation Response of Locally Exposed Heart: Integrated Global Transcriptomics and Proteomics Analysis

(2016) Vikram Subramanian et al.   JOURNAL OF PROTEOME RESEARCH

Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy

(2016) Ritwik Datta et al.   MOLECULAR AND CELLULAR BIOLOGY

Improved bioavailability of targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiac microenvironment

(2016) Aramita Ray et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Hsp90/Cdc37 assembly modulates TGFβ receptor-II to act as a profibrotic regulator of TGFβ signaling during cardiac hypertrophy

(2015) Ritwik Datta et al.   CELLULAR SIGNALLING

Getting to the Heart of the Matter

(2015) Andrew Leask   CIRCULATION RESEARCH

A spatio-temporal cardiomyocyte targeted vector system for efficient delivery of therapeutic payloads to regress cardiac hypertrophy abating bystander effect

(2015) Santanu Rana et al.   JOURNAL OF CONTROLLED RELEASE

Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor α/γ

(2015) Jademilson Celestino dos Santos et al.   JOURNAL OF STRUCTURAL BIOLOGY

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

An Ideal PPAR Response Element Bound to and Activated by PPARα

(2015) John Tzeng et al.   PLoS One

Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway

(2014) M Jiao et al.   Cell Death & Disease

Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine

(2013) Jyotirmoy Ghosh et al.   BIOCHIMIE

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A map of the PPARα transcription regulatory network for primary human hepatocytes

(2013) Patrick D. McMullen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Regulation of TAK1/TAB1-Mediated IL-1β Signaling by Cytoplasmic PPARβ/δ

(2013) Josefine Stockert et al.   PLoS One

The Novel PPAR α/γ Dual Agonist MHY 966 Modulates UVB–Induced Skin Inflammation by Inhibiting NF-κB Activity

(2013) Min Hi Park et al.   PLoS One

Role of α-crystallin B as a regulatory switch in modulating cardiomyocyte apoptosis by mitochondria or endoplasmic reticulum during cardiac hypertrophy and myocardial infarction

(2013) A Mitra et al.   Cell Death & Disease

Therapeutic Potential of Terminalia Arjuna in Cardiovascular Disorders

(2012) Subir K. Maulik et al.   American Journal of Cardiovascular Drugs

Improved model quality assessment using ProQ2

(2012) Arjun Ray et al.   BMC BIOINFORMATICS

NF-κB mediated miR-26a regulation in cardiac fibrosis

(2012) Chuanyu Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-Step Atomic-Level Energy Minimization

(2011) Dong Xu et al.   BIOPHYSICAL JOURNAL

New Take on the Role of Angiotensin II in Cardiac Hypertrophy and Fibrosis

(2011) Mazen Kurdi et al.   HYPERTENSION

Structural Basis for Iloprost as a Dual Peroxisome Proliferator-activated Receptor α/δ Agonist

(2011) Lihua Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) Attenuates Interleukin-6 (IL-6)-induced Collagen Synthesis and Resultant Hypertrophy in Rat Heart

(2011) Saiful Anam Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of 2′-hydroxyl sampling on the conformational properties of RNA: Update of the CHARMM all-atom additive force field for RNA

(2011) Elizabeth J. Denning et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

SwissParam: A fast force field generation tool for small organic molecules

(2011) Vincent Zoete et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Isolation, characterisation and cytotoxicity study of arjunolic acid fromTerminalia arjuna

(2011) A. Sai Ramesh et al.   NATURAL PRODUCT RESEARCH

BSP-SLIM: A blind low-resolution ligand-protein docking approach using predicted protein structures

(2011) Hui Sun Lee et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart

(2010) E. E. Creemers et al.   CARDIOVASCULAR RESEARCH

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation

(2010) Renfang Mao et al.   CELLULAR SIGNALLING

Whole Grape Intake Impacts Cardiac Peroxisome Proliferator-Activated Receptor and Nuclear Factor κB Activity and Cytokine Expression in Rats With Diastolic Dysfunction

(2010) E. Mitchell Seymour et al.   HYPERTENSION

Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated byTerminalia arjuna(Roxb.)

(2010) Santosh Kumar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension

(2010) Jian Fang et al.   PHYTOMEDICINE

Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

(2010) Vivek R. Yadav et al.   Toxins

Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures

(2009) Takuji Oyama et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload

(2008) Nadia Hedhli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

(2008) P. J.H. Smeets et al.   CARDIOVASCULAR RESEARCH

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH