Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

Oleanolic Acid Induces Prostacyclin Release in Human Vascular Smooth Muscle Cells through a Cyclooxygenase-2-Dependent Mechanism

(2018) José Martínez-González et al.   JOURNAL OF NUTRITION

Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NF-kappaB signaling pathways

(2010) Sahdeo Prasad et al.   CANCER BIOLOGY & THERAPY

Combination of ginsenoside Rg3 with docetaxel enhances the susceptibility of prostate cancer cells via inhibition of NF-κB

(2010) Sun Mi Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism

(2010) Zi Chen et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells

(2010) Xianghong Wang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of Nuclear Factor- B Signaling Pathway

(2010) K. B. Harikumar et al.   MOLECULAR PHARMACOLOGY

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion

(2009) Franziska B. Mullauer et al.   APOPTOSIS

Lupeol induces p53 and cyclin-B-mediated G2/M arrest and targets apoptosis through activation of caspase in mouse skin

(2009) Nidhi Nigam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lupeol triterpene, a novel diet-based microtubule targeting agent: Disrupts survivin/cFLIP activation in prostate cancer cells

(2009) Mohammad Saleem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective role of betulinic acid on TNF-α-induced cell adhesion molecules in vascular endothelial cells

(2009) Jung Joo Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism

(2009) Dorrah Deeb et al.   BIOCHEMICAL PHARMACOLOGY

Asiatic Acid Induces Colon Cancer Cell Growth Inhibition and Apoptosis through Mitochondrial Death Cascade

(2009) Xue-Lian Tang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae)

(2009) Rosa Tundis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

(2009) Tai-Guo Liu et al.   BMC CANCER

Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, α- and β-amyrin, in a mouse model of colitis

(2009) CE Vitor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lupeol, a Dietary Triterpene, Inhibited Growth, and Induced Apoptosis Through Down-Regulation of DR3 in SMMC7721 Cells

(2009) Lin Zhang et al.   CANCER INVESTIGATION

Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

(2009) Kin Tak Chan et al.   CANCER LETTERS

Suppression of cFLIP by Lupeol, a Dietary Triterpene, Is Sufficient to Overcome Resistance to TRAIL-Mediated Apoptosis in Chemoresistant Human Pancreatic Cancer Cells

(2009) I. Murtaza et al.   CANCER RESEARCH

Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

(2009) N. H. Thoennissen et al.   CANCER RESEARCH

Acetyl-11-Keto- -Boswellic Acid Inhibits Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2-Mediated Angiogenesis

(2009) X. Pang et al.   CANCER RESEARCH

Lupeol inhibits proliferation of human prostate cancer cells by targeting  -catenin signaling

(2009) M. Saleem et al.   CARCINOGENESIS

Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells

(2009) Vivian W.Y. Lui et al.   CARCINOGENESIS

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model

(2009) Dae Yong Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Estrogen-like activities of saikosaponin-d in vitro: A pilot study

(2009) Peng Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion-induced liver injury by inhibiting NF-κB activation

(2009) Jin Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis

(2009) Yang Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells

(2009) Sowmyalakshmi Srinivasan et al.   INTERNATIONAL JOURNAL OF CANCER

Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid

(2009) Ruth Chu et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction

(2009) Tao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling

(2009) Chunyan Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation

(2009) Vincent Kam Wai Wong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting NF- B with a Natural Triterpenoid Alleviates Skin Inflammation in a Mouse Model of Psoriasis

(2009) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway

(2009) Jian-zhen Shan et al.   Journal of Zhejiang University-SCIENCE B

Hyperactivated NF- B and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells

(2009) M. N. Ndlovu et al.   MOLECULAR AND CELLULAR BIOLOGY

Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1

(2009) Ajaikumar B. Kunnumakkara et al.   MOLECULAR CANCER RESEARCH

Cucurbitacin B induces G2arrest and apoptosisviaa reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells

(2009) Shusuke Yasuda et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reactive Oxygen Species-Dependent Activation of Bax and Poly(ADP-ribose) Polymerase-1 Is Required for Mitochondrial Cell Death Induced by Triterpenoid Pristimerin in Human Cervical Cancer Cells

(2009) J.-Y. Byun et al.   MOLECULAR PHARMACOLOGY

Mechanism of betulinic acid inhibition of collagen biosynthesis in human endometrial adenocarcinoma cells

(2009) E. KARNA et al.   NEOPLASMA

Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation

(2009) Vanisree Mulabagal et al.   PHYTOTHERAPY RESEARCH

Anti-inflammatory Effects of Madecassic Acid via the Suppression of NF-κB Pathway in LPS-Induced RAW 264.7 Macrophage Cells

(2009) Jong-Heon Won et al.   PLANTA MEDICA

Avicin D: A Protein Reactive Plant Isoprenoid Dephosphorylates Stat 3 by Regulating Both Kinase and Phosphatase Activities

(2009) Valsala Haridas et al.   PLoS One

Natural Triterpenic Diols Promote Apoptosis in Astrocytoma Cells through ROS-Mediated Mitochondrial Depolarization and JNK Activation

(2009) Rubén Martín et al.   PLoS One

Avicin D, a Plant Triterpenoid, Induces Cell Apoptosis by Recruitment of Fas and Downstream Signaling Molecules into Lipid Rafts

(2009) Zhi-Xiang Xu et al.   PLoS One

Oleanane Triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR

(2009) Dorrah Deeb et al.   PROSTATE

Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines

(2009) Sheng-lei Yan et al.   TOXICOLOGY IN VITRO

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE

Inhibitory effect of acetyl-11-keto-β-boswellic acid on androgen receptor by interference of Sp1 binding activity in prostate cancer cells

(2008) Hui-Qing Yuan et al.   BIOCHEMICAL PHARMACOLOGY

Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells

(2008) Dong Yeok Shin et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF- B with antimyeloma activity in vitro and in vivo

(2008) R. E. Tiedemann et al.   BLOOD

Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells

(2008) M. Emília Juan et al.   BRITISH JOURNAL OF NUTRITION

Saponins derived from the roots of Platycodon grandiflorum inhibit HT-1080 cell invasion and MMPs activities: Regulation of NF-κB activation via ROS signal pathway

(2008) Kyung Jin Lee et al.   CANCER LETTERS

Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells

(2008) Mun-Ock Kim et al.   CANCER LETTERS

Acetyl-Keto- -Boswellic Acid Induces Apoptosis through a Death Receptor 5-Mediated Pathway in Prostate Cancer Cells

(2008) M. Lu et al.   CANCER RESEARCH

Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum

(2008) Ichiko Miyamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix

(2008) Jae-Yong Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells

(2008) K.A. Manu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tubocapsanolide A Inhibits Transforming Growth Factor-β-activating Kinase 1 to Suppress NF-κB-induced CCR7

(2008) Mei-Ren Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins

(2008) Wen-Ying Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Avicin D Selectively Induces Apoptosis and Downregulates p-STAT-3, bcl-2, and Survivin in Cutaneous T-Cell Lymphoma Cells

(2008) Chunlei Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration

(2008) Milan Popovic et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor–κB Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors

(2008) Hironori Takei et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Ganoderic Acid Me Inhibits Tumor Invasion Through Down-Regulating Matrix Metalloproteinases 2/9 Gene Expression

(2008) Nian-Hong Chen et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

18β-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity

(2008) Chung Soo Lee et al.   LIFE SCIENCES

Betulinic acid suppresses constitutive and TNFα-induced NF-κB activation and induces apoptosis in human prostate carcinoma PC-3 cells

(2008) Thangaiyan Rabi et al.   MOLECULAR CARCINOGENESIS

Ursolic acid inhibits IL-1β or TNF-α-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-ζ and downregulating the MMP-9 expression

(2008) Hsiu-Chen Huang et al.   MOLECULAR CARCINOGENESIS

Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice

(2008) M MENEGAZZI et al.   PHARMACOLOGICAL RESEARCH

Cancer Chemopreventive Potential of Apples, Apple Juice, and Apple Components

(2008) Clarissa Gerhauser   PLANTA MEDICA

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

(2008) Fung-Ming Siu et al.   PROTEOMICS

Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells

(2008) Patricia Marçal da Costa et al.   TOXICOLOGY IN VITRO

Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenin-type saponins from the root of Platycodon grandiflorum

(2008) Yong Xie et al.   VACCINE

Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11-Keto-β-Boswellic Acid in LPS-Challenged ApoE −/− Mice

(2007) Clarisse Cuaz-Pérolin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways

(2007) Kyung-Jin Yun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ginsenoside Re Reduces Insulin Resistance through Inhibition of c-Jun NH2-Terminal Kinase and Nuclear Factor-κB

(2007) Zhiguo Zhang et al.   MOLECULAR ENDOCRINOLOGY