The ATAD2 bromodomain binds different acetylation marks on the histone H4 in similar fuzzy complexes

Bromodomain Histone Readers and Cancer

(2017) Abhinav K Jain et al.   JOURNAL OF MOLECULAR BIOLOGY

Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation

(2016) Jean-Rémy Marchand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions

(2016) Jian Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The “Gatekeeper” Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains

(2016) Andrea Unzue et al.   JOURNAL OF MEDICINAL CHEMISTRY

OUP accepted manuscript

(2016)   NUCLEIC ACIDS RESEARCH

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

(2015) Guillaume Poncet-Montange et al.   BIOCHEMICAL JOURNAL

Peptide Binding to a PDZ Domain by Electrostatic Steering via Nonnative Salt Bridges

(2015) Nicolas Blöchliger et al.   BIOPHYSICAL JOURNAL

Binding Mode of Acetylated Histones to Bromodomains: Variations on a Common Motif

(2015) Jean-Rémy Marchand et al.   ChemMedChem

Intrinsically disordered proteins: emerging interaction specialists

(2015) Peter Tompa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

(2015) Paul Bamborough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

(2015) Emmanuel H. Demont et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells

(2015) Yuichi Morozumi et al.   Journal of Molecular Cell Biology

The bromodomain: From epigenome reader to druggable target

(2014) Roberto Sanchez et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Fragment-Based Screening of the Bromodomain of ATAD2

(2014) Mary J. Harner et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain

(2014) Apirat Chaikuad et al.   MedChemComm

High-Resolution Visualisation of the States and Pathways Sampled in Molecular Dynamics Simulations

(2014) Nicolas Blöchliger et al.   Scientific Reports

A scalable algorithm to order and annotate continuous observations reveals the metastable states visited by dynamical systems

(2013) Nicolas Blöchliger et al.   COMPUTER PHYSICS COMMUNICATIONS

Direct detection of neuropeptide dynorphin A binding to the second extracellular loop of the κ opioid receptor using a soluble protein scaffold

(2013) Johannes Björnerås et al.   FEBS Journal

Does bromodomain flexibility influence histone recognition?

(2013) Sandra Steiner et al.   FEBS LETTERS

Mechanism and Kinetics of Acetyl-Lysine Binding to Bromodomains

(2013) A. Magno et al.   Journal of Chemical Theory and Computation

Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites

(2013) Yupeng Zheng et al.   Nature Communications

Epigenetics meets mathematics: Towards a quantitative understanding of chromatin biology

(2012) Philipp A. Steffen et al.   BIOESSAYS

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Combinatorial complexity in chromatin structure and function: revisiting the histone code

(2012) Oliver J Rando   CURRENT OPINION IN GENETICS & DEVELOPMENT

The bromodomain interaction module

(2012) Panagis Filippakopoulos et al.   FEBS LETTERS

Efficient Construction of Mesostate Networks from Molecular Dynamics Trajectories

(2012) Andreas Vitalis et al.   Journal of Chemical Theory and Computation

More than just tails: intrinsic disorder in histone proteins

(2012) Zhenling Peng et al.   Molecular BioSystems

A benchmark for chromatin binding measurements in live cells

(2012) Davide Mazza et al.   NUCLEIC ACIDS RESEARCH

Regulation of the H4 tail binding and folding landscapes via Lys-16 acetylation

(2012) D. A. Potoyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex

(2012) Zhijian Duan et al.   PROSTATE

Disordered Binding of Small Molecules to Aβ(12–28)

(2011) Marino Convertino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

(2011) Martin Philpott et al.   Molecular BioSystems

Fuzziness: linking regulation to protein dynamics

(2011) Monika Fuxreiter   Molecular BioSystems

Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark

(2010) A. S. Revenko et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

(2010) C Caron et al.   ONCOGENE

Fast signals and slow marks: the dynamics of histone modifications

(2010) Teresa K. Barth et al.   TRENDS IN BIOCHEMICAL SCIENCES

ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors

(2009) M. Ciro et al.   CANCER RESEARCH

Fundamental Aspects of Protein−Protein Association Kinetics

(2009) G. Schreiber et al.   CHEMICAL REVIEWS

Protein dynamics and conformational disorder in molecular recognition

(2009) Tanja Mittag et al.   JOURNAL OF MOLECULAR RECOGNITION

Transcription Dynamics

(2009) Gordon L. Hager et al.   MOLECULAR CELL

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES