Neuropilins: A New Target for Cancer Therapy

Neuropilin-2 and epithelial to mesenchymal transition in colorectal cancer cells.

(2017) C. Grandclement et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models

(2011) Andrea Casazza et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Polysialic acid is required for neuropilin-2a/b-mediated control of CCL21-driven chemotaxis of mature dendritic cells and for their migration in vivo

(2011) Angela Rey-Gallardo et al.   GLYCOBIOLOGY

Small Interfering RNAs Induce Target-Independent Inhibition of Tumor Growth and Vasculature Remodeling in a Mouse Model of Hepatocellular Carcinoma

(2010) Mathieu Bergé et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting neuropilin-1 in human leukemia and lymphoma

(2010) K. Karjalainen et al.   BLOOD

Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta

(2010) Yelena Glinka et al.   CARCINOGENESIS

Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21

(2010) A. Rey-Gallardo et al.   GLYCOBIOLOGY

Neuropilin-1 Mediates Divergent R-Smad Signaling and the Myofibroblast Phenotype

(2010) Ying Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

(2010) Sheng Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

(2010) Ashley Jarvis et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Mutated Soluble Neuropilin-2 B Domain Antagonizes Vascular Endothelial Growth Factor Bioactivity and Inhibits Tumor Progression

(2010) E. Geretti et al.   MOLECULAR CANCER RESEARCH

Hormonal Regulation and Distinct Functions of Semaphorin-3B and Semaphorin-3F in Ovarian Cancer

(2010) D. Joseph et al.   MOLECULAR CANCER THERAPEUTICS

Peptide-based interference of the transmembrane domain of neuropilin-1 inhibits glioma growth in vivo

(2010) C Nasarre et al.   ONCOGENE

Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: Its implication in tumor progression and angiogenesis

(2010) Yu Cai et al.   PATHOLOGY RESEARCH AND PRACTICE

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Inhibition of Neuropilin-1 by RNA-Interference and its Angiostatic Potential in the Treatment of Hepatocellular Carcinoma

(2010) E. Raskopf et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Identification of Signaling Systems in Proliferating and Involuting Phase Infantile Hemangiomas by Genome-Wide Transcriptional Profiling

(2009) Monica L. Calicchio et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression

(2009) Hironao Yasuoka et al.   BMC CANCER

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Neuropilin‐1 is not a marker of human Foxp3+Treg

(2009) Pierre Milpied et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

αvβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis

(2009) Stephen D. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Semaphorin signaling in cancer cells and in cells of the tumor microenvironment - two sides of a coin

(2009) L. Capparuccia et al.   JOURNAL OF CELL SCIENCE

Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubular cells

(2009) Herbert Schramek et al.   LABORATORY INVESTIGATION

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

Neuropilins: structure, function and role in disease

(2008) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells

(2008) Hongjie Pan et al.   BREAST CANCER RESEARCH AND TREATMENT

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Semaphorin 3B Inhibits the Phosphatidylinositol 3-Kinase/Akt Pathway through Neuropilin-1 in Lung and Breast Cancer Cells

(2008) E. Castro-Rivera et al.   CANCER RESEARCH

Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer

(2008) Min Li et al.   CANCER SCIENCE

Neuropilin-2-Mediated Tumor Growth and Angiogenesis in Pancreatic Adenocarcinoma

(2008) N. A. Dallas et al.   CLINICAL CANCER RESEARCH

High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer

(2008) Sriparna Ghosh et al.   HUMAN PATHOLOGY

Neuropilin-1 Expression on Regulatory T Cells Enhances Their Interactions with Dendritic Cells during Antigen Recognition

(2008) Milka Sarris et al.   IMMUNITY

The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment

(2008) Charlotte Rolny et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Therapeutic Targeting of Neuropilin-2 on Colorectal Carcinoma Cells Implanted in the Murine Liver

(2008) M. J. Gray et al.   JNCI-Journal of the National Cancer Institute

Neuropilin-1 in acute myeloid leukemia: Expression and role in proliferation and migration of leukemia cells

(2008) Lin Lu et al.   LEUKEMIA & LYMPHOMA

Neuropilin-1 is expressed by chronic lymphocytic leukemia B cells

(2008) Grzegorz S. Nowakowski et al.   LEUKEMIA RESEARCH

Successful Inhibition of Tumor Development by Specific Class-3 Semaphorins Is Associated with Expression of Appropriate Semaphorin Receptors by Tumor Cells

(2008) Boaz Kigel et al.   PLoS One