Measuring high-altitude adaptation

Impact of urbanisation and altitude on the incidence of, and risk factors for, hypertension

(2017) Antonio Bernabé-Ortiz et al.   HEART

Are Permanent Residents of High Altitude Fully Adapted to Their Hypoxic Environment?

(2017) John B. West   HIGH ALTITUDE MEDICINE & BIOLOGY

Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude

(2017) Edward Gilbert-Kawai et al.   JOURNAL OF APPLIED PHYSIOLOGY

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders

(2017) Tsewang Tashi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Down-Regulation ofEPAS1Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia

(2017) Yi Peng et al.   MOLECULAR BIOLOGY AND EVOLUTION

Metabolic basis to Sherpa altitude adaptation

(2017) James A. Horscroft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human genetic adaptation to high altitudes: Current status and future prospects

(2017) Lorna G. Moore   QUATERNARY INTERNATIONAL

Evolutionary history of Tibetans inferred from whole-genome sequencing

(2017) Hao Hu et al.   PLoS Genetics

Exhaled nitric oxide is associated with postnatal adaptation to hypoxia in Tibetan and non-Tibetan newborn infants

(2016) Panpan Wu et al.   ACTA PAEDIATRICA

Hypoxemia, oxygen content, and the regulation of cerebral blood flow

(2016) Ryan L. Hoiland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sleep-Disordered Breathing and Vascular Function in Patients With Chronic Mountain Sickness and Healthy High-Altitude Dwellers

(2016) Emrush Rexhaj et al.   CHEST

Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns

(2016) Norina N. Gassmann et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary artery pressure and arterial oxygen saturation in people living at high or low altitude: systematic review and meta-analysis

(2016) Rodrigo Soria et al.   JOURNAL OF APPLIED PHYSIOLOGY

The effect of α1 -adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea level and high altitude

(2016) Michael M. Tymko et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adaptation to Life in the High Andes: Nocturnal Oxyhemoglobin Saturation in Early Development

(2016) Catherine Mary Hill et al.   SLEEP

Effects of race and sex on cerebral hemodynamics, oxygen delivery and blood flow distribution in response to high altitude

(2016) Jie Liu et al.   Scientific Reports

Adaptation to Life in the High Andes: Nocturnal Oxyhemoglobin Saturation in Early Development

(2016) Catherine Mary Hill et al.   SLEEP

Surname-Inferred andean ancestry is associated with child stature and limb lengths at high altitude in Peru, but not at sea level

(2015) Emma Pomeroy et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence

(2015) Haiyi Lou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Larger FVC and FEV1among Tibetans compared to Han born and raised at high altitude

(2015) Charles A Weitz et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction

(2015) Colleen Glyde Julian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Glucose Homeostasis During Short-term and Prolonged Exposure to High Altitudes

(2015) Orison O. Woolcott et al.   ENDOCRINE REVIEWS

Metabolic aspects of high-altitude adaptation in Tibetans

(2015) Ri-Li Ge et al.   EXPERIMENTAL PHYSIOLOGY

Developmental Effects Determine Submaximal Arterial Oxygen Saturation in Peruvian Quechua

(2015) Melisa Kiyamu et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

HMOX2Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans

(2015) Deying Yang et al.   HUMAN MUTATION

New genetic and physiological factors for excessive erythrocytosis and Chronic Mountain Sickness

(2015) Francisco C. Villafuerte   JOURNAL OF APPLIED PHYSIOLOGY

Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity

(2015) T. S. Simonson et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Novel Candidate Region for Genetic Adaptation to High Altitude in Andean Populations

(2015) Guido Valverde et al.   PLoS One

Neonatal Oxygenation, Pulmonary Hypertension, and Evolutionary Adaptation to High Altitude (2013 Grover Conference series)

(2015) Susan Niermeyer et al.   Pulmonary Circulation

Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes

(2015) Vanessa Cristina Jacovas et al.   PLoS One

Widespread Signals of Convergent Adaptation to High Altitude in Asia and America

(2014) Matthieu Foll et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aerobic capacity of Peruvian Quechua: A test of the developmental adaptation hypothesis

(2014) Melisa Kiyamu et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Cardiovascular function in healthy Himalayan high-altitude dwellers

(2014) R.M. Bruno et al.   ATHEROSCLEROSIS

Short-term adaptation and chronic cardiac remodelling to high altitude in lowlander natives and Himalayan Sherpa

(2014) Mike Stembridge et al.   EXPERIMENTAL PHYSIOLOGY

Time Course Variations in the Mechanisms by Which Cerebral Oxygen Delivery Is Maintained on Exposure to Hypoxia/Altitude

(2014) Christopher Imray et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Genetic Variation in SENP1 and ANP32D as Predictors of Chronic Mountain Sickness

(2014) Amy M. Cole et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing

(2014) Daisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Higher Estrogen Levels During Pregnancy in Andean Than European Residents of High Altitude Suggest Differences in Aromatase Activity

(2014) Shelton M. Charles et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA

(2014) Emilia Huerta-Sánchez et al.   NATURE

A genetic mechanism for Tibetan high-altitude adaptation

(2014) Felipe R Lorenzo et al.   NATURE GENETICS

Pre-eclampsia part 2: prediction, prevention and management

(2014) Tinnakorn Chaiworapongsa et al.   Nature Reviews Nephrology

Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude

(2014) Abigail W. Bigham et al.   PHYSIOLOGICAL GENOMICS

King of the Mountains: Tibetan and Sherpa Physiological Adaptations for Life at High Altitude

(2014) Edward T. Gilbert-Kawai et al.   PHYSIOLOGY

Autonomic Cardiovascular Responses in Acclimatized Lowlanders on Prolonged Stay at High Altitude: A Longitudinal Follow Up Study

(2014) Priyanka Dhar et al.   PLoS One

The Andean Adaptive Toolkit to Counteract High Altitude Maladaptation: Genome-Wide and Phenotypic Analysis of the Collas

(2014) Christina A. Eichstaedt et al.   PLoS One

Paleoindian settlement of the high-altitude Peruvian Andes

(2014) Kurt Rademaker et al.   SCIENCE

Admixture facilitates genetic adaptations to high altitude in Tibet

(2014) Choongwon Jeong et al.   Nature Communications

Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes

(2014) Nitin Udpa et al.   GENOME BIOLOGY

Andean and Tibetan patterns of adaptation to high altitude

(2013) Abigail W. Bigham et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Whole-Genome Sequencing Uncovers the Genetic Basis of Chronic Mountain Sickness in Andean Highlanders

(2013) Dan Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Oxidative-Nitrosative Stress and Systemic Vascular Function in Highlanders With and Without Exaggerated Hypoxemia

(2013) Damian M. Bailey et al.   CHEST

Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia

(2013) Nayia Petousi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era

(2013) Nayia Petousi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cerebral Pressure–Flow Relationship in Lowlanders and Natives at High Altitude

(2013) Jonathan D Smirl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation

(2013) Nia C. S. Lewis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic Signatures Reveal High-Altitude Adaptation in a Set of Ethiopian Populations

(2013) Emilia Huerta-Sánchez et al.   MOLECULAR BIOLOGY AND EVOLUTION

Graduated effects of high-altitude hypoxia and highland ancestry on birth size

(2013) Rudy Soria et al.   PEDIATRIC RESEARCH

Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis)

(2013) Colleen Glyde Julian et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Developmental and genetic components explain enhanced pulmonary volumes of female peruvian quechua

(2012) Melisa Kiyamu et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

(2012) Hong Wa Yung et al.   FASEB JOURNAL

Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA

(2012) Colleen Glyde Julian et al.   Journal of Maternal-Fetal & Neonatal Medicine

Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans

(2012) F. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Architecture of Adaptations to High Altitude in Ethiopia

(2012) Gorka Alkorta-Aranburu et al.   PLoS Genetics

Genetic adaptation to high altitude in the Ethiopian highlands

(2012) Laura B Scheinfeldt et al.   GENOME BIOLOGY

Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight

(2011) Colleen G. Julian et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude

(2011) Vaughn A. Browne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Systemic Vascular Dysfunction in Patients With Chronic Mountain Sickness

(2011) Stefano F. Rimoldi et al.   CHEST

Differences in mtDNA whole sequence between Tibetan and Han populations suggesting adaptive selection to high altitude

(2011) Mingliang Gu et al.   GENE

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

On the Origin of Tibetans and Their Genetic Basis in Adapting High-Altitude Environments

(2011) Binbin Wang et al.   PLoS One

Elevated pulmonary artery pressure among Amhara highlanders in Ethiopia

(2010) Brian D. Hoit et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Brain Blood Flow in Andean and Himalayan High-Altitude Populations: Evidence of Different Traits for the Same Environmental Constraint

(2010) Gerard FA Jansen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Genome-Wide Search for Signals of High-Altitude Adaptation in Tibetans

(2010) S. Xu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas

(2010) Y. Peng et al.   MOLECULAR BIOLOGY AND EVOLUTION

Hypoglycemia and the Origin of Hypoxia-Induced Reduction in Human Fetal Growth

(2010) Stacy Zamudio et al.   PLoS One

Natural selection on EPAS1 (HIF2 ) associated with low hemoglobin concentration in Tibetan highlanders

(2010) C. M. Beall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do Anti-angiogenic or Angiogenic Factors Contribute to the Protection of Birth Weight at High Altitude Afforded by Andean Ancestry?

(2010) R. Daniela Dávila et al.   Reproductive Sciences

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

(2010) Abigail Bigham et al.   PLoS Genetics

Prolonged high-altitude residence impacts verbal working memory: an fMRI study

(2010) Xiaodan Yan et al.   EXPERIMENTAL BRAIN RESEARCH

Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth

(2009) Colleen Glyde Julian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Placental mTOR links maternal nutrient availability to fetal growth

(2009) Sara Roos et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Outcome of hospital deliveries of women living at high altitude: a study from Lhasa in Tibet

(2008) Yeshe Yangzom et al.   ACTA PAEDIATRICA

Evidence that parent-of-origin affects birth-weight reductions at high altitude

(2008) Adam Bennett et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

(2008) Hong-wa Yung et al.   AMERICAN JOURNAL OF PATHOLOGY

Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude

(2008) Colleen Glyde Julian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Do high-altitude natives have enhanced exercise performance at altitude?

(2008) Tom D. Brutsaert   Applied Physiology Nutrition and Metabolism

Tibetans Retained Innate Ability Resistance to Acute Hypoxia after Long Period of Residing at Sea Level

(2008) Zhao-Nian Zhou et al.   Journal of Physiological Sciences

Adaptation and Mal-Adaptation to Ambient Hypoxia; Andean, Ethiopian and Himalayan Patterns

(2008) Guoqiang Xing et al.   PLoS One

Cerebrovascular Responses to Hypoxia and Hypocapnia in Ethiopian High Altitude Dwellers

(2007) Victoria E. Claydon et al.   STROKE