Repurposing of nucleoside- and nucleobase-derivative drugs as antibiotics and biofilm inhibitors

Escherichia coli Harboringmcr-1andblaCTX-Mon a Novel IncF Plasmid: First Report ofmcr-1in the United States

(2016) Patrick McGann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

5-azacytidine induces transcriptome changes in Escherichia coli via DNA methylation-dependent and DNA methylation-independent mechanisms

(2016) Kevin T. Militello et al.   BMC MICROBIOLOGY

A study of the utility of azathioprine metabolite testing in myasthenia gravis

(2016) William Rae et al.   JOURNAL OF NEUROIMMUNOLOGY

Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway

(2016) Sung Ryeol Park et al.   Nature Communications

The Path From Bench to Bedside

(2016) Mason Wright Freeman et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The Clinical Efficacy of Azathioprine in Korean Patients with Atopic Dermatitis

(2015) Hemin Lee et al.   Annals of Dermatology

The Complex Mechanism of Antimycobacterial Action of 5-Fluorouracil

(2015) Vinayak Singh et al.   CHEMISTRY & BIOLOGY

Repurposing Non-Antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections

(2015) Waleed Younis et al.   CURRENT PHARMACEUTICAL DESIGN

Azathioprine treatment of intractable pruritus: A retrospective review

(2015) Alexander Maley et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

PubChem Substance and Compound databases

(2015) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

The human gut resistome

(2015) W. van Schaik   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Socially mediated induction and suppression of antibiosis during bacterial coexistence

(2015) Monica I. Abrudan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical treatment of pandrug-resistant bacterial infection consulted by clinical pharmacist

(2015) Yang Zhi-Wen et al.   SAUDI PHARMACEUTICAL JOURNAL

The Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro

(2015) Mukesh Kumar Yadav et al.   PLoS One

Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections

(2015) Shankar Thangamani et al.   Scientific Reports

A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms

(2014) Fany Reffuveille et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Prediction of resistance development against drug combinations by collateral responses to component drugs

(2014) C. Munck et al.   Science Translational Medicine

The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability

(2013) Davide Antoniani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biologically inspired strategies for combating bacterial biofilms

(2013) Meghan S Blackledge et al.   CURRENT OPINION IN PHARMACOLOGY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Applying insights from biofilm biology to drug development — can a new approach be developed?

(2013) Thomas Bjarnsholt et al.   NATURE REVIEWS DRUG DISCOVERY

Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity

(2013) F. Imperi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caffeine as a Potential Quorum Sensing Inhibitor

(2013) Siti Norizan et al.   SENSORS

Enhancing the utility of existing antibiotics by targeting bacterial behaviour?

(2012) Geraint B Rogers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies

(2012) Max V. Ranall et al.   CURRENT DRUG TARGETS

Gemcitabine is active against clinical multiresistant Staphylococcus aureus strains and is synergistic with gentamicin

(2012) Lars Petter Jordheim et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Effect of 5-azacytidine on in vitro biofilm formation of Streptococcus pneumoniae

(2012) Mukesh Kumar Yadav et al.   MICROBIAL PATHOGENESIS

The Pyrimidine Nucleotide Biosynthetic Pathway Modulates Production of Biofilm Determinants in Escherichia coli

(2012) Marco Garavaglia et al.   PLoS One

Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism

(2012) Louise Egeblad et al.   PLoS One

Novel classes of antibiotics or more of the same?

(2011) Anthony RM Coates et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antibiotics as Signal Molecules

(2011) Diego Romero et al.   CHEMICAL REVIEWS

Pyrimidine Salvage Pathway in Mycobacterium tuberculosis

(2011) A. D. Villela et al.   CURRENT MEDICINAL CHEMISTRY

Zidovudine (AZT) has a bactericidal effect on enterobacteria and induces genetic modifications in resistant strains

(2011) A. Doléans-Jordheim et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Indole Affects Biofilm Formation in Bacteria

(2011) Mingxi Hu et al.   INDIAN JOURNAL OF MICROBIOLOGY

The LuxS-Dependent Quorum-Sensing System Regulates Early Biofilm Formation by Streptococcus pneumoniae Strain D39

(2011) Jorge E. Vidal et al.   INFECTION AND IMMUNITY

Complex c-di-GMP Signaling Networks Mediate Transition between Virulence Properties and Biofilm Formation in Salmonella enterica Serovar Typhimurium

(2011) Irfan Ahmad et al.   PLoS One

Molecular mechanisms of compounds affecting bacterial biofilm formation and dispersal

(2010) Paolo Landini et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Anti-infective external coating of central venous catheters: A randomized, noninferiority trial comparing 5-fluorouracil with chlorhexidine/silver sulfadiazine in preventing catheter colonization*

(2010) J. Matthias Walz et al.   CRITICAL CARE MEDICINE

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Gemcitabine Functions Epigenetically by Inhibiting Repair Mediated DNA Demethylation

(2010) Andrea Schäfer et al.   PLoS One

Gallium Maltolate Treatment Eradicates Pseudomonas aeruginosa Infection in Thermally Injured Mice

(2009) K. DeLeon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound

(2009) Can Attila et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

(2009) M. Schaefer et al.   CANCER RESEARCH

Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer

(2009) William B. Parker   CHEMICAL REVIEWS

The role of antibiotics and antibiotic resistance in nature

(2009) Rustam I. Aminov   ENVIRONMENTAL MICROBIOLOGY

Cyclic di-GMP signalling controls virulence properties ofSalmonella entericaserovar Typhimurium at the mucosal lining

(2009) Agaristi Lamprokostopoulou et al.   ENVIRONMENTAL MICROBIOLOGY

Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosis

(2009) M. Y. Krishnan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1

(2009) M. J. Dapp et al.   JOURNAL OF VIROLOGY

Brominated Furanones Inhibit Biofilm Formation by Salmonella enterica Serovar Typhimurium

(2008) J. C. A. Janssens et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibiotics as signals that trigger specific bacterial responses

(2008) Alicia Fajardo et al.   CURRENT OPINION IN MICROBIOLOGY

Nucleoside analogs: molecular mechanisms signaling cell death

(2008) B Ewald et al.   ONCOGENE

Antibiotics and Antibiotic Resistance Genes in Natural Environments

(2008) J. L. Martinez   SCIENCE

Uracil influences quorum sensing and biofilm formation inPseudomonas aeruginosaand fluorouracil is an antagonist

(2008) Akihiro Ueda et al.   Microbial Biotechnology

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY