Article
Pharmacology & Pharmacy
Esteban Cruz, Vicki Sifniotis, Zeynep Sumer-Bayraktar, Mouhamad Reslan, Lorna Wilkinson-White, Stuart Cordwell, Veysel Kayser
Summary: Protein aggregation is a common issue in the production and clinical use of therapeutic monoclonal antibodies. By inserting N-glycosylation sequons in the Fab region, the physical stability of the protein can be increased, preventing self-association of antibody monomers and protein aggregation. Further studies show that additional glycosylation can enhance physical stability, shedding light on potential applications for the development of better antibodies.
Review
Pharmacology & Pharmacy
Karin M. Torres-Obreque, Giovanna P. Meneguetti, Jorge J. Muso-Cachumba, Valker A. Feitosa, Joao H. P. M. Santos, Sonia P. M. Ventura, Carlota O. Rangel-Yagui
Summary: This article explores the concept and advantages of biobetters, as well as current methods and trends for improving biological drugs, ranging from glycosylation to bioconjugation. Research is ongoing to investigate novel polymers and innovative genetic engineering techniques for drug improvement.
DRUG DISCOVERY TODAY
(2022)
Article
Green & Sustainable Science & Technology
Erwei Dong, Bing Fu, Yuntan Li, Jianing Jin, Hengyu Hu, Yajing Ma, Zecheng Zhang, Qianwen Xu, Zhu Cheng
Summary: This study analyzed the strengths, weaknesses, opportunities, and threats of Hainan's sport tourism development and proposed future directions, including event-oriented sport tourism, prioritizing sport motivation, identifying major sport tourism markets, making rational use of sport tourism resources, and nurturing sport culture.
Article
Spectroscopy
Robert J. Soto, David S. Meriage, Robin L. Wagner, Ting Wang, David J. Semin
Summary: Raman spectroscopy proves useful for rapid identity verification of biotherapeutic protein products in solution, with the development of specific spectral models through PCA to reduce false-negative rates. Instrumental variance is compensated for through spectral preprocessing algorithms, leading to successful evaluation on different Raman instruments without false-positive analyses. This work lays the groundwork for implementing Raman ID methods for solution-based protein products in the biopharmaceutical industry.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Geosciences, Multidisciplinary
Stephen Coss, Michael T. T. Durand, C. K. Shum, Yuchan Yi, Xiao Yang, Tamlin Pavelsky, Augusto Getirana, Dai Yamazaki
Summary: River channels play a crucial role in storing large volumes of water globally, affecting ecological and biogeochemical processes. However, there is currently no observational constraint on the quantity of water stored in river channels. This study introduces a 26-year record of remotely sensed volumetric channel water storage (CWS) change on 26 major rivers worldwide, revealing the significant contribution of mainstem CWS climatology amplitude to terrestrial water storage variability in basins.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Environmental Sciences
G. Rachid, I. Alameddine, M. El-Fadel
Summary: This study examined the risks of seawater intrusion in data scarce aquifers along the Eastern Mediterranean by conducting a SWOT analysis. It found alarming signs of SWI in some areas, with varying levels of adaptive capabilities across different countries. The study also showed a positive correlation between risks and the status of SWI, providing an effective decision-making tool for regions with data scarcity.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Article
Pharmacology & Pharmacy
Maria Sinegubova, Ivan Vorobiev, Anatoly Klishin, Dmitry Eremin, Nadezhda Orlova, Natalya Orlova, Mikhail Polzikov
Summary: A purification process for r-hFSH centered on immunoaffinity chromatography with single-domain recombinant camelid antibodies was developed, allowing for pharmaceutical quality r-hFSH to be obtained from Chinese hamster ovary cell culture broth. The use of immunoaffinity matrix was suitable for industrial use and stable for at least 40 full chromatography cycles, with leaked single-domain antibody ligand completely removed by subsequent purification steps. The industrial purification process yielded consistent batches of r-hFSH with high purity and bioactivity levels.
Article
Pharmacology & Pharmacy
Khalid A. Alnaqbi, Agnes Bellanger, Alex Brill, Gilberto Castaneda-Hernandez, Ana Clopes Estela, Olga Delgado Sanchez, Pilar Garcia-Alfonso, Pius Gyger, Daniel Heinrich, Germain Hezard, Adriana Kakehasi, Cheryl Koehn, Olivier Mariotte, Francesco Mennini, Sonia Perez-Tapia, Michele Pistollato, Rowan Saada, Tadanori Sasaki, George Tambassis, Marc Thill, Gustavo Werutsky, Tim Wilsdon, Steven Simoens
Summary: This study compares the sustainability of biosimilar policies across 17 countries and finds that European countries generally have higher sustainability scores due to their experience and developed policy frameworks. Key factors contributing to sustainability include manufacturing and R&D of biosimilars, policies ensuring safety and quality, exemption from health technology assessment, and efforts to address misconceptions. However, improvements are needed in biosimilar contracting, education, and understanding. Overall, sustainability depends on healthcare systems, pharmaceutical market access policies, and experience with biosimilar use and policies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Calef Sanchez-Trasvina, Miguel Flores-Gatica, Daniela Enriquez-Ochoa, Marco Rito-Palomares, Karla Mayolo-Deloisa
Summary: Proteins with biorecognition properties are widely used as therapeutic agents, and can be modified to improve pharmacokinetic properties and stability. Purification steps are crucial for ensuring the quality and safety of the final product, with chromatographic methods being the gold standard for downstream processing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Immunology
Ferdinando D'Amico, Virginia Solitano, Daniel Aletaha, Ailsa Hart, Fernando Magro, Carlo Selmi, Siew C. Ng, Sameer Al Awadhi, Ernest Choy, Hendrik Schulze-Koops, Peter Bossuyt, Pablo A. Olivera, Paulo Gustavo Kotze, Subrata Ghosh, Laurent Peyrin-Biroulet, Silvio Danese
Summary: Biobetters are a new type of treatment for patients with IMIDs, which require clinical studies to validate their definition. An appropriate balance between clinical outcomes and costs, as well as a shared decision between physicians and patients, should guide the use of biobetters.
AUTOIMMUNITY REVIEWS
(2021)
Review
Genetics & Heredity
Magdalena Johanna Konopka, Billy Sperlich, Gerard Rietjens, Maurice Petrus Zeegers
Summary: Exercise genetics/genomics is a rapidly growing research field with various strengths and opportunities, but it also faces weaknesses and threats. This study conducted a systematic SWOT analysis of non-systematic reviews to identify the strengths, weaknesses, opportunities, and threats associated with exercise genetics/genomics. The analysis revealed five strengths, nine weaknesses, six opportunities, and three threats. The strengths include technological advancements, empirical evidence, growing research discipline, establishment of consortia, and acceptance/accessibility of genetic testing. The weaknesses are related to low research quality, complexity of exercise-related traits, low generalizability, high costs, genotype scores, reporting bias, invasive methods, research progress, and causality. The opportunities include precision exercise, omics, multicenter studies, and genetic testing as a commercial, screening, and anti-doping detection tool. The threats are associated with ethical issues, direct-to-consumer genetic testing companies, and gene doping. This study provides insights into the current state of research in sport genetics/genomics, highlighting the potential of this field while emphasizing the need for further advancements in methodology and ethics to address the recognized weaknesses and threats.
FRONTIERS IN GENETICS
(2023)
Article
Environmental Studies
Abel Meza, Muammer Koc, Mohammed Saleh Al-Sada
Summary: During the 2010s, the global LNG markets underwent significant changes and challenges, including the impact of the COVID-19 pandemic. This article highlights the need to analyze the LNG market, exporters, importers, production, and capacity using a SWOT analysis. It concludes that in the short term, the LNG market will recover faster than other energy sectors, and Qatar will remain a reliable supplier. In the long term, the crisis may bring balance and new opportunities, benefiting Qatar.
Article
Green & Sustainable Science & Technology
Shuyang Yu, Dan Wang
Summary: This research aims to provide a reference strategy for Open Universities in China to develop non-academic education during their transition period. The study found that, despite some drawbacks, favorable national policies and citizens' learning needs have created good opportunities for the development of Open Universities.
Article
Chemistry, Physical
Muhammad Imran Khan, Sami G. Al-Ghamdi
Summary: The serious threat of climate change has prompted GCC countries to aggressively seek clean energy sources. Recently, these countries have announced carbon emission targets, with some aiming for net-zero emissions by 2050 or 2060. Governments and energy companies around the world are betting on hydrogen to lower emissions. However, there are obstacles to the adoption of a green hydrogen economy in Gulf countries, including high production costs, infrastructure and transportation issues, regulation, and demand. This study analyzes the obstacles and future prospects of hydrogen economy in the GCC region using SWOT analysis, concluding that while GCC countries have the potential to lead in hydrogen, they need to take risks to compete globally, and the growth of the hydrogen economy depends on external factors beyond their control.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Environmental Sciences
Tomas Bakalar, Henrieta Pavolova, Alexander Tokarcik
Summary: The study proposed a sustainable management model based on water quality for river basins, including monitoring, analysis, surveys, and case studies, to promote the development of surface water quality in the basin. The model covers principles of sustainable development and implementation measures.
Review
Pharmacology & Pharmacy
Shruti U. Rawal, Bhoomika M. Patel, Mayur M. Patel
Summary: This article discusses the importance and challenges of the blood-brain barrier and blood-cerebrospinal fluid barrier in drug delivery, as well as different strategies and methods for brain-targeted drugs, emphasizing the need for further research and prospects, especially in non-invasive approaches.
Article
Cell Biology
Vivek R. Bora, Dhruv Gohel, Rajesh Singh, Bhoomika M. Patel
Summary: This study investigates the effects of several anti-diabetic drugs on cardiovascular complications associated with cancer cachexia. The results show that these drugs can alleviate cardiac atrophy and improve hemodynamic status, potentially offering a treatment option for cardiovascular complications in cancer cachexia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Education, Scientific Disciplines
Rory E. Kim, Terry D. Church, Manjunath Ghate, Mayur Patel, Tejal Mehta, Mehul Naik, Terrence F. Graham, Ian S. Haworth
Summary: This report describes the design, implementation, and student perceptions of an online course co-taught by two pharmacy schools in different countries. The course focused on cross-cultural learning and students reported gaining new knowledge, perspectives, and transferable skills as a result.
PHARMACY EDUCATION
(2022)
Article
Cell Biology
Darshak Shah, Mit Joshi, Jigna Shah, Bhoomika M. Patel
Summary: Stroke cachexia is a condition characterized by inflammation, muscle loss, and poor prognosis in stroke patients. This study evaluated the potential of buspirone, a 5-HT1a agonist, to improve the symptoms of stroke cachexia. The results showed that treatment with buspirone improved the behavioral parameters, increased food intake and body weight, and decreased inflammatory markers in stroke cachexia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Saumitra Gajjar, Vivek Bora, Bhoomika M. Patel
Summary: The study evaluated the role of simvastatin in colon cancer associated with type 2 diabetes mellitus. It was found that simvastatin controlled diabetes and colon cancer in animal models, reduced CDK4 mRNA expression in colon tissues, and induced apoptosis. These findings suggest that simvastatin could be considered for repositioning in the treatment of colon cancer in patients with diabetes mellitus.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Nanoscience & Nanotechnology
Kunj Vyas, Maharshsinh Rathod, Mayur M. Patel
Summary: Oral cancer is a deadly malignancy with high failure rates in current chemotherapeutic drugs due to toxicity and poor tumor targeting. Nanotechnology-based drug delivery systems hold great promise for precise targeting and improving patient health and survival rates in oral cancer.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Kunj Vyas, Mayur M. Patel
Summary: Complications of the liver are severe diseases, with liver fibrosis as the initial stage and cirrhosis as the final stage. Effective drug delivery methods are critical for treating liver problems, but there are challenges in targeting the liver due to its metabolic capacity and physiological barriers. Nanotechnology-based delivery systems and targeted drug delivery to hepatic stellate cells (HSCs) have shown potential in treating fibrosis. This review highlights recent breakthroughs in drug and gene-based nano and targeted delivery systems for liver fibrosis and cirrhosis.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Shruti Rawal, Shubham Khot, Vivek Bora, Bhoomika Patel, Mayur M. Patel
Summary: This study develops an orally administrable, folate-receptor-targeted Nanostructured lipid carriers (NLCs) of Docetaxel (DX) to overcome the bioavailability and toxicity issues of intravenous administration in lung cancer chemotherapy, showing promising antitumor efficacy and safety.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Oncology
Mit Joshi, Bhoomika M. Patel
Summary: Cancer cachexia is a wasting syndrome driven by chronic inflammation and high energy expenditure. Uncoupling proteins (UCPs) play an important role in cancer cachexia by increasing the body's overall energy utilization. This review provides new insights into the role of UCPs in cancer cachexia and highlights their potential as a target for treating this syndrome.
Review
Immunology
Vivek P. Chavda, Gargi Jogi, Srusti Dave, Bhoomika M. Patel, Lakshmi Vineela Nalla, Krishna Koradia
Summary: mRNA vaccines harness the cells' protein production mechanism by providing mRNA instructions for constructing specific proteins. BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) are newly approved mRNA-based COVID-19 vaccines that have demonstrated high protection and efficacy. There are currently five more mRNA-based COVID-19 vaccine candidates in various stages of clinical development.
Review
Chemistry, Multidisciplinary
Dhruvi Solanki, Preksha Vinchhi, Mayur M. Patel
Summary: Wound healing is a complex physiological process that involves cellular and molecular events to reconstruct the skin after tissue damage. It is crucial to treat chronic wounds to improve patients' quality of life. Hydrogels, which have moistening and biocompatible properties, are playing a leading role in engineering ideal wound dressings.
Article
Oncology
Kruti Patel, Vivek Bora, Bhoomika Patel
Summary: Type 2 diabetes mellitus increases the risk of colon cancer. This study found that sodium orthovanadate (SOV) plays a protective role in colon cancer associated with diabetes by inhibiting cell proliferation, angiogenesis, and inducing apoptosis.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Srusti Dave, Bhoomika M. Patel
Summary: Cancer cachexia is a debilitating syndrome characterized by muscle atrophy and fat loss, caused by various mechanisms including the release of cytokines and the disruption of metabolic pathways. This review focuses on the imbalances in protein synthesis and degradation in skeletal muscles.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vivek P. Chavda, Vrashabh V. Sugandhi, Chandrakantsing V. Pardeshi, Rahul Jaywant Patil, Mit Joshi, Bhoomika Patel, Avinash Khadela, Rajashri Bezbaruah, Bedanta Bhattacharjee, Pankti C. Balar, Lalitkumar K. Vora
Summary: Exosomes are multivesicular bodies that release their cargo into surrounding body fluids by fusing with the plasma membrane. They transfer various biomolecules between cells, making them potential therapeutic drug delivery systems. The use of exosomes for cancer detection and prognosis has gained considerable interest. In addition to existing engineering approaches, novel methodologies for exosomal alteration show promise in advancing therapeutic medicines for cancer. This review highlights the theranostic potential of exosomes in various types of cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
