Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity

In VivoModeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease

(2017) Stephen W. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster

(2016) Ann-Christin Niehoff et al.   ANALYTICAL CHEMISTRY

Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila

(2016) Zhou-Jing Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia

(2016) S. Chiang et al.   CLINICAL SCIENCE

Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis

(2016) Marta Carrasco-Rando et al.   DEVELOPMENT

Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity

(2016) Isaac A. Adedara et al.   NEUROCHEMICAL RESEARCH

Peumus boldus (Boldo) Aqueous Extract Present Better Protective Effect than Boldine Against Manganese-Induced Toxicity in D. melanogaster

(2016) Matheus Chimelo Bianchini et al.   NEUROCHEMICAL RESEARCH

Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease

(2016) Sirena Soriano et al.   PLoS One

Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration

(2016) Kuchuan Chen et al.   eLife

Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals

(2016) Kuchuan Chen et al.   eLife

Manganese Is Essential for Neuronal Health

(2015) Kyle J. Horning et al.   Annual Review of Nutrition

Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues

(2015) Christopher D. Richards et al.   BIOMETALS

Iron is a specific cofactor for distinct oxidation- and aggregation-dependent A  toxicity mechanisms in a Drosophila model

(2015) S. Ott et al.   Disease Models & Mechanisms

Digital gene expression profiling (DGE) of cadmium-treated Drosophila melanogaster

(2015) Delong Guan et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich׳s ataxia

(2015) Juan A. Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multicopper oxidase-1 orthologs from diverse insect species have ascorbate oxidase activity

(2015) Zeyu Peng et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila

(2015) Kesang Dechen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Iron homeostasis in insects: Insights fromDrosophilastudies

(2015) Xiaona Tang et al.   IUBMB LIFE

Deferiprone in Friedreich ataxia: A 6-Month randomized controlled trial

(2014) Massimo Pandolfo et al.   ANNALS OF NEUROLOGY

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry

(2014) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Characterization of the effect of Cr(VI) on humoral innate immunity usingDrosophila melanogaster

(2014) P. Pragya et al.   ENVIRONMENTAL TOXICOLOGY

The active role of vitamin C in mammalian iron metabolism: Much more than just enhanced iron absorption!

(2014) Darius J.R. Lane et al.   FREE RADICAL BIOLOGY AND MEDICINE

ZIP2 Protein, a Zinc Transporter, Is Associated with Keratinocyte Differentiation

(2014) Yu Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

(2014) D. Leyva-Illades et al.   JOURNAL OF NEUROSCIENCE

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide  -amyloid (1-42)

(2014) J. Everett et al.   Journal of the Royal Society Interface

Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster

(2014) S. Meyer et al.   Metallomics

Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition

(2014) B.Y. Kong et al.   MOLECULAR HUMAN REPRODUCTION

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Correction: The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways

(2014) Toshiyuki Fukada et al.   PLoS One

Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength

(2014) S. Hojyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

(2014) Guiran Xiao et al.   eLife

ACUTE EXPOSURE OFDrosophila melanogasterTO PARAQUAT CAUSES OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION

(2013) Ravikumar Hosamani et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter

(2013) Ira Kukic et al.   BIOCHEMICAL JOURNAL

Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation

(2013) Qiuhong Qin et al.   BMC BIOLOGY

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup

(2013) C. Groth et al.   DEVELOPMENT

The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers

(2013) Nadine D. Younan et al.   FASEB JOURNAL

Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia

(2013) Sirena Soriano et al.   GENE

Drosophila melanogasteras a model system of aluminum toxicity and aging

(2013) Ewelina Kijak et al.   Insect Science

Gene regulation and epigenetics in Friedreich's ataxia

(2013) Cihangir Yandim et al.   JOURNAL OF NEUROCHEMISTRY

Friedreich Ataxia: Neuropathology Revised

(2013) Arnulf H. Koeppen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

What can flies tell us about copper homeostasis?

(2013) Adam Southon et al.   Metallomics

Negative Correlation of LIV-1 and E-Cadherin Expression in Hepatocellular Carcinoma Cells

(2013) Rongxi Shen et al.   PLoS One

Essential Role of the Zinc Transporter ZIP9/SLC39A9 in Regulating the Activations of Akt and Erk in B-Cell Receptor Signaling Pathway in DT40 Cells

(2013) Masanari Taniguchi et al.   PLoS One

Compound Heterozygous Mutations in SLC30A2/ZnT2 Results in Low Milk Zinc Concentrations: A Novel Mechanism for Zinc Deficiency in a Breast-Fed Infant

(2013) Naoya Itsumura et al.   PLoS One

Presenilin Promotes Dietary Copper Uptake

(2013) Adam Southon et al.   PLoS One

The Zinc Transporter Zip5 (Slc39a5) Regulates Intestinal Zinc Excretion and Protects the Pancreas against Zinc Toxicity

(2013) Jim Geiser et al.   PLoS One

The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells

(2013) Stephen A. Myers et al.   PLoS One

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

(2013) G. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron Absorption in Drosophila melanogaster

(2013) Konstantinos Mandilaras et al.   Nutrients

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Inherited Copper Transport Disorders: Biochemical Mechanisms, Diagnosis, and Treatment

(2012) Hiroko Kodama et al.   CURRENT DRUG METABOLISM

Effects of Hg(II) Exposure on MAPK Phosphorylation and Antioxidant System inD. melanogaster

(2012) M. T. Paula et al.   ENVIRONMENTAL TOXICOLOGY

Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster

(2012) Xiaona Tang et al.   FASEB JOURNAL

Functional significance of the copper transporter ATP7 in peptidergic neurons and endocrine cells inDrosophila melanogaster

(2012) Azza Sellami et al.   FEBS LETTERS

An Overview and Update ofATP7AMutations Leading to Menkes Disease and Occipital Horn Syndrome

(2012) Zeynep Tümer   HUMAN MUTATION

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster

(2012) J. C. Lye et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis

(2012) Helen J. Bosomworth et al.   Metallomics

Cellular transport and homeostasis of essential and nonessential metals

(2012) Ebany J. Martinez-Finley et al.   Metallomics

Alumina nanoparticles alter rhythmic activities of local interneurons in the antennal lobe ofDrosophila

(2012) Naya Huang et al.   Nanotoxicology

Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster

(2012) M. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome

(2012) J. Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linkage Disequilibrium and Haplotype Analysis of the ATP7B Gene in Alzheimer's Disease

(2012) Rosanna Squitti et al.   REJUVENATION RESEARCH

Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster

(2012) E. Bonilla et al.   TOXICOLOGY

Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research

(2012) Helmut V. B. Hirsch et al.   Frontiers in Genetics

Iron, Copper, and Zinc Transport: Inhibition of Divalent Metal Transporter 1 (DMT1) and Human Copper Transporter 1 (hCTR1) by shRNA

(2011) Alejandra Espinoza et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: a model to study Parkinsonism

(2011) Leonardo Bonilla-Ramirez et al.   BIOMETALS

Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila

(2011) Haiqing Hua et al.   BIOMETALS

Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia

(2011) Youichirou Higashi et al.   GLIA

Cellular prion protein is essential for oligomeric amyloid- -induced neuronal cell death

(2011) W. Kudo et al.   HUMAN MOLECULAR GENETICS

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue Nonspecific Alkaline Phosphatase Is Activated via a Two-step Mechanism by Zinc Transport Complexes in the Early Secretory Pathway

(2011) Ayako Fukunaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of MtnE, the fifth metallothionein member in Drosophila

(2011) Lilit Atanesyan et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase

(2011) L. Bettedi et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Catecholamines up integrates dopamine synthesis and synaptic trafficking

(2011) Zhe Wang et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

ATP7A Gene Addition to the Choroid Plexus Results in Long-term Rescue of the Lethal Copper Transport Defect in a Menkes Disease Mouse Model

(2011) Anthony Donsante et al.   MOLECULAR THERAPY

Tracing the tracks of genotoxicity by trivalent and hexavalent chromium in Drosophila melanogaster

(2011) Manish Mishra et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity testing of two lead-compounds in somatic cells of Drosophila melanogaster

(2011) Erico R. Carmona et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Correction: Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

MTF-1-Mediated Repression of the Zinc Transporter Zip10 Is Alleviated by Zinc Restriction

(2011) Louis A. Lichten et al.   PLoS One

A Transgenic Drosophila Model for Arsenic Methylation Suggests a Metabolic Rationale for Differential Dose-Dependent Toxicity Endpoints

(2011) Jorge G. Muñiz Ortiz et al.   TOXICOLOGICAL SCIENCES

Missense Mutations in the Copper Transporter Gene ATP7A Cause X-Linked Distal Hereditary Motor Neuropathy

(2010) Marina L. Kennerson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Somatic mosaicism in Menkes disease suggests choroid plexus-mediated copper transport to the developing brain

(2010) Anthony Donsante et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease

(2010) Sarah L. Hands et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Zinc supplement greatly improves the condition of parkin mutant Drosophila

(2010) Nidhi Saini et al.   BIOLOGICAL CHEMISTRY

Conservation of copper-transporting P(IB)-type ATPase function

(2010) Adam Southon et al.   BIOMETALS

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro

(2010) Rebecca A Bozym et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Understanding the molecular mechanisms of Friedreich's ataxia to develop therapeutic approaches

(2010) S. Schmucker et al.   HUMAN MOLECULAR GENETICS

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific interplay between copper uptake and efflux in Drosophila

(2010) Tim Binks et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene

(2010) Damiano Porcelli et al.   MITOCHONDRION

Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production

(2010) Zhihao Wu et al.   NEUROBIOLOGY OF AGING

Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways

(2010) Nidhi Saini et al.   NEUROBIOLOGY OF DISEASE

Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary gland

(2009) Shannon L. Kelleher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Overexpression ofDrosophila mitoferrinin l(2)mbn cells results in dysregulation of Fer1HCH expression

(2009) Christoph Metzendorf et al.   BIOCHEMICAL JOURNAL

SLC39A9 (ZIP9) Regulates Zinc Homeostasis in the Secretory Pathway: Characterization of the ZIP Subfamily I Protein in Vertebrate Cells

(2009) Wataru MATSUURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment

(2009) S. Bahadorani et al.   Disease Models & Mechanisms

Menkes disease

(2009) Zeynep Tümer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease

(2009) Thomas Rival et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster

(2009) Xiaoxi Wang et al.   FASEB JOURNAL

Multicellular models of Friedreich ataxia

(2009) Hélène Puccio   JOURNAL OF NEUROLOGY

Metalloproteomics, metalloproteomes, and the annotation of metalloproteins

(2009) Wolfgang Maret   Metallomics

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster

(2009) Helmut V.B. Hirsch et al.   NEUROTOXICOLOGY

Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead

(2009) Douglas M. Ruden et al.   NEUROTOXICOLOGY

Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae

(2009) T. He et al.   NEUROTOXICOLOGY

New developments in the regulation of intestinal copper absorption

(2009) Peter VE van den Berghe et al.   NUTRITION REVIEWS

Pb2+: An endocrine disruptor in Drosophila?

(2009) Helmut V.B. Hirsch et al.   PHYSIOLOGY & BEHAVIOR

Spondylocheiro Dysplastic Form of the Ehlers-Danlos Syndrome—An Autosomal-Recessive Entity Caused by Mutations in the Zinc Transporter Gene SLC39A13

(2008) Cecilia Giunta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

(2008) Johanna Myllyharju   ANNALS OF MEDICINE

Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

(2008) Neal C. Burton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia

(2008) A. Campanella et al.   HUMAN MOLECULAR GENETICS

Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues

(2008) Richard Burke et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Instability of Superoxide Dismutase 1 ofDrosophilain Mutants Deficient for Its Cognate Copper Chaperone

(2008) Kim Kirby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malvolio is a copper transporter in Drosophila melanogaster

(2008) A. Southon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Investigating Arsenic Susceptibility from a Genetic Perspective in Drosophila Reveals a Key Role for Glutathione Synthetase

(2008) Jorge G. Muñiz Ortiz et al.   TOXICOLOGICAL SCIENCES