What can flies tell us about copper homeostasis?

MEDNIK syndrome: a novel defect of copper metabolism treatable by zinc acetate therapy

(2013) Diego Martinelli et al.   BRAIN

Presenilin Promotes Dietary Copper Uptake

(2013) Adam Southon et al.   PLoS One

Three-Dimensional Atlas of Iron, Copper, and Zinc in the Mouse Cerebrum and Brainstem

(2012) Dominic J. Hare et al.   ANALYTICAL CHEMISTRY

The Human ZIP4 Transporter Has Two Distinct Binding Affinities and Mediates Transport of Multiple Transition Metals

(2012) Sagar Antala et al.   BIOCHEMISTRY

Efficient metal-specific transcription activation by Drosophila MTF-1 requires conserved cysteine residues in the carboxy-terminal domain

(2012) Sharon K. Marr et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Aceruloplasminemia

(2012) Satoshi Kono   CURRENT DRUG TARGETS

Functional significance of the copper transporter ATP7 in peptidergic neurons and endocrine cells inDrosophila melanogaster

(2012) Azza Sellami et al.   FEBS LETTERS

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is MtnE, the fifth Drosophila metallothionein, functionally distinct from the other members of this polymorphic protein family?

(2012) Sílvia Pérez-Rafael et al.   Metallomics

The Drosophila melanogaster Genetic Reference Panel

(2012) Trudy F. C. Mackay et al.   NATURE

Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster

(2012) M. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation

(2012) H. I. Sims et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability

(2011) Haiqing Hua et al.   BIOLOGICAL CHEMISTRY

Iron, Copper, and Zinc Transport: Inhibition of Divalent Metal Transporter 1 (DMT1) and Human Copper Transporter 1 (hCTR1) by shRNA

(2011) Alejandra Espinoza et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Evidence for evolutionary constraints in Drosophila metal biology

(2011) Maryam Sadraie et al.   BIOMETALS

Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila

(2011) Haiqing Hua et al.   BIOMETALS

Drosophila melanogaster prophenoloxidases respond inconsistently to Cu2+ and have different activity in vitro

(2011) Fei Liu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Dissection of Drosophila MTF-1 reveals a domain for differential target gene activation upon copper overload vs. copper starvation

(2011) Viola Günther et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of MtnE, the fifth metallothionein member in Drosophila

(2011) Lilit Atanesyan et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase

(2011) L. Bettedi et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

Detection of Genetically Altered Copper Levels in Drosophila Tissues by Synchrotron X-Ray Fluorescence Microscopy

(2011) Jessica C. Lye et al.   PLoS One

Conservation of copper-transporting P(IB)-type ATPase function

(2010) Adam Southon et al.   BIOMETALS

Cardiac Copper Deficiency Activates a Systemic Signaling Mechanism that Communicates with the Copper Acquisition and Storage Organs

(2010) Byung-Eun Kim et al.   Cell Metabolism

The ADP-ribosylation factor 1 (Arf1) is involved in regulating copper uptake

(2010) Adam Southon et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cellsin VivoThat Is Controlled at the Level of Protein Stability

(2010) Yasuhiro Nose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheDrosophilaCopper Transporter Ctr1C Functions in Male Fertility

(2010) Dominik Steiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific interplay between copper uptake and efflux in Drosophila

(2010) Tim Binks et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene

(2010) Damiano Porcelli et al.   MITOCHONDRION

Control of Alzheimer's Amyloid Beta Toxicity by the High Molecular Weight Immunophilin FKBP52 and Copper Homeostasis in Drosophila

(2010) Reiko Sanokawa-Akakura et al.   PLoS One

Syntaxin 5 Is Required for Copper Homeostasis in Drosophila and Mammals

(2010) Melanie Norgate et al.   PLoS One

Hormonal and nutritional regulation of insect fat body development and function

(2009) Ying Liu et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

The multi-layered regulation of copper translocating P-type ATPases

(2009) Nicholas A. Veldhuis et al.   BIOMETALS

A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment

(2009) S. Bahadorani et al.   Disease Models & Mechanisms

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease

(2009) Thomas Rival et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Drosophila melanogaster as a Model Organism of Brain Diseases

(2009) Astrid Jeibmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Copper-dependent Recycling of hCTR1, the Human High Affinity Copper Transporter

(2009) Shannon A. Molloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects

(2009) Haiqing Hua et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

(2009) Jennifer L. Mummery-Widmer et al.   NATURE

New developments in the regulation of intestinal copper absorption

(2009) Peter VE van den Berghe et al.   NUTRITION REVIEWS

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Drosophila melanogaster cytochrome P450 genes

(2009) H. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DrosophilaModels of Neurodegenerative Diseases

(2008) Bingwei Lu et al.   Annual Review of Pathology-Mechanisms of Disease

Diagnosis of Wilson's Disease: A Comprehensive Review

(2008) Chloe M. Mak et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Diagnosis and treatment of Wilson disease: An update

(2008) Eve A. Roberts et al.   HEPATOLOGY

Expression and localisation of the essential copper transporter DmATP7 in Drosophila neuronal and intestinal tissues

(2008) Richard Burke et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Instability of Superoxide Dismutase 1 ofDrosophilain Mutants Deficient for Its Cognate Copper Chaperone

(2008) Kim Kirby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malvolio is a copper transporter in Drosophila melanogaster

(2008) A. Southon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY