miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Principles of miRNA-Target Regulation in Metazoan Models

(2013) Epaminondas Doxakis   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Trophic Factor Gene Therapy for Parkinson's Disease

(2013) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

MiR-7 Triggers Cell Cycle Arrest at the G1/S Transition by Targeting Multiple Genes Including Skp2 and Psme3

(2013) Noelia Sanchez et al.   PLoS One

Downregulation of miR-223 and miR-153 mediates mechanical stretch-stimulated proliferation of venous smooth muscle cells via activation of the insulin-like growth factor-1 receptor

(2012) Lei Song et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

New Agents Promote Neuroprotection in Parkinson’s Disease Models

(2012) Claudia Maria Miranda Santos   CNS & Neurological Disorders-Drug Targets

MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic  -Cells

(2012) Y. Wang et al.   DIABETES

Ginsenoside Rb1 Prevents MPP+-Induced Apoptosis in PC12 Cells by Stimulating Estrogen Receptors with Consequent Activation of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK

(2012) Ryo Hashimoto et al.   Evidence-based Complementary and Alternative Medicine

MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma

(2012) YuXiang Fang et al.   HEPATOLOGY

MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients

(2012) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovering the first microRNA-targeted drug

(2012) Morten Lindow et al.   JOURNAL OF CELL BIOLOGY

Cooperative action of JNK and AKT/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells

(2012) Jezabel Rodríguez-Blanco et al.   JOURNAL OF NEUROSCIENCE RESEARCH

MicroRNAs in Parkinson's disease

(2012) M. Maral Mouradian   NEUROBIOLOGY OF DISEASE

Kinases and kinase signaling pathways: Potential therapeutic targets in Parkinson's disease

(2012) Gang Wang et al.   PROGRESS IN NEUROBIOLOGY

Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer

(2012) Ziqing Wu et al.   PROSTATE

Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

(2012) J H Zhu et al.   Cell Death & Disease

Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP+-induced mitochondrial dysfunctions in neuronal cells

(2011) Ying Piao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis

(2011) Wei Cui et al.   NEUROCHEMISTRY INTERNATIONAL

Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells

(2011) Kai Zhang et al.   NEUROPHARMACOLOGY

FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of rapamycin pathway and inhibiting RTP801 expression in Parkinson's disease models

(2011) X.-Q. Bao et al.   NEUROSCIENCE

Direct Interaction of α-Synuclein and AKT Regulates IGF-1 Signaling: Implication of Parkinson Disease

(2011) Ji-Yun Chung et al.   NEUROSIGNALS

Upcoming treatments in Parkinson's disease, including gene therapy

(2011) Robert L Rodnitzky   PARKINSONISM & RELATED DISORDERS

The Promise of Neuroprotective Agents in Parkinson?s Disease

(2011) Stacey E. Seidl et al.   Frontiers in Neurology

Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signaling

(2010) Lei Wang et al.   APOPTOSIS

Overexpression of α-Synuclein Down-Regulates BDNF Expression

(2010) Yuhe Yuan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

(2010) Epaminondas Doxakis   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration

(2010) Daniele Cartelli et al.   JOURNAL OF NEUROCHEMISTRY

Distinct Roles of c-Jun N-Terminal Kinase Isoforms in Neurite Initiation and Elongation during Axonal Regeneration

(2010) M. Barnat et al.   JOURNAL OF NEUROSCIENCE

Microtubule Stabilization by Bone Morphogenetic Protein Receptor-Mediated Scaffolding of c-Jun N-Terminal Kinase Promotes Dendrite Formation

(2010) M. Podkowa et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways

(2010) Xian-Guo Chen et al.   MOLECULAR CARCINOGENESIS

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons

(2010) Felix Junyent et al.   NEUROCHEMISTRY INTERNATIONAL

Brain-derived Neurotrophic Factor Enhances the Basal Rate of Protein Synthesis by Increasing Active Eukaryotic Elongation Factor 2 Levels and Promoting Translation Elongation in Cortical Neurons

(2009) Nobuyuki Takei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

(2009) Gerardo A Morfini et al.   NATURE NEUROSCIENCE

Akt signal transduction dysfunction in Parkinson's disease

(2009) Suzanne Timmons et al.   NEUROSCIENCE LETTERS

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma

(2008) B. Kefas et al.   CANCER RESEARCH

Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK

(2008) Gareth M Thomas et al.   EMBO JOURNAL

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

(2008) M. Rosner et al.   HUMAN MOLECULAR GENETICS

Rheb and mTOR Regulate Neuronal Polarity through Rap1B

(2008) Ying-Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

(2008) Tobias Thomas et al.   JOURNAL OF NEUROCHEMISTRY

Selective Activation of p38 Mitogen-Activated Protein Kinase in Dopaminergic Neurons of Substantia Nigra Leads to Nuclear Translocation of p53 in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice

(2008) S. Karunakaran et al.   JOURNAL OF NEUROSCIENCE

Multisite Phosphorylation Regulates Bim Stability and Apoptotic Activity

(2008) Anette Hübner et al.   MOLECULAR CELL

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells

(2007) Kazuhiro Nakaso et al.   NEUROSCIENCE LETTERS