The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

(2016) Naila Rabbani et al.   GLYCOCONJUGATE JOURNAL

Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study

(2016)   INTENSIVE CARE MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells

(2016) Jakob Morgenstern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling

(2016) Taeyeop Park et al.   Journal of Neuroinflammation

RAGE-mediated inflammation in patients with septic shock

(2016) Stefan Hofer et al.   JOURNAL OF SURGICAL RESEARCH

The reciprocal interaction of sympathetic nervous system and cAMP-PKA-NF-kB pathway in immune suppression after experimental stroke

(2016) Lei Zuo et al.   NEUROSCIENCE LETTERS

Mitochondrial Function in Sepsis

(2016) Nishkantha Arulkumaran et al.   SHOCK

The Endothelium in Sepsis

(2016) Can Ince et al.   SHOCK

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

(2015) Naila Rabbani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study

(2015) Florian Uhle et al.   MEDIATORS OF INFLAMMATION

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Cytopathic Hypoxia and Sepsis

(2015) Mitchell P. Fink   Pediatric Critical Care Medicine

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Defence against methylglyoxal in Group AStreptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?

(2015) May M. Zhang et al.   Pathogens and Disease

Glyoxalase Centennial conference: introduction, history of research on the glyoxalase system and future prospects

(2014) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Metabolic response to the stress of critical illness

(2014) J.-C. Preiser et al.   BRITISH JOURNAL OF ANAESTHESIA

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery

(2014) Virginia Vanasco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

(2014) Kirsi-Maija Kaukonen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

(2014) Raymond P. Donnelly et al.   JOURNAL OF IMMUNOLOGY

Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples

(2014) Naila Rabbani et al.   Nature Protocols

Cytokine and Nitric Oxide Levels in Patients with Sepsis – Temporal Evolvement and Relation to Platelet Mitochondrial Respiratory Function

(2014) Fredrik Sjövall et al.   PLoS One

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

(2013) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Reactive Metabolites and AGE-RAGE-Mediated Inflammation in Patients following Liver Transplantation

(2013) Thorsten Brenner et al.   MEDIATORS OF INFLAMMATION

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Generation of Nitric Oxide and Reactive Oxygen Species by Neutrophils and Monocytes From Septic Patients and Association With Outcomes

(2012) Sidnéia Sousa Santos et al.   SHOCK

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Cyclic AMP: a selective modulator of NF-κB action

(2011) Sarah Gerlo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

(2011) A. K. Berner et al.   DIABETOLOGIA

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

A Global Perspective of the Genetic Basis for Carbonyl Stress Resistance

(2011) Shawn Hoon et al.   G3-Genes Genomes Genetics

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose

(2010) Arti Dhar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reactive Metabolites and AGE/RAGE-Mediated Cellular Dysfunction Affect the Aging Process – A Mini-Review

(2010) Thomas H. Fleming et al.   GERONTOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

(2009) D. Yao et al.   DIABETES

Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

(2009) Beatriz Duran-Jimenez et al.   DIABETES

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

Stress hyperglycaemia

(2009) Kathleen M Dungan et al.   LANCET

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

The GAIT system: a gatekeeper of inflammatory gene expression

(2009) Rupak Mukhopadhyay et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL

Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

(2008) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular energetic metabolism in sepsis: The need for a systems approach

(2008) Jane E. Carré et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Role of Glyceraldehyde 3-Phosphate Dehydrogenase in the Development and Progression of Diabetic Retinopathy

(2008) M. Kanwar et al.   DIABETES

Benefits and Risks of Tight Glucose Control in Critically Ill Adults

(2008) Renda Soylemez Wiener et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inflammatory Response in Microvascular Endothelium in Sepsis: Role of Oxidants

(2008) Gediminas Cepinskas et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The tandem of free radicals and methylglyoxal

(2007) Miklós Péter Kalapos   CHEMICO-BIOLOGICAL INTERACTIONS