Association of Smoking, Alcohol Use, and Betel Quid Chewing with Epigenetic Aberrations in Cancers

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

(2017) Eleonore Maury et al.   Epigenetics

Anti-leukemic effects of HDACi Belinostat and HMTi 3-Deazaneplanocin A on human acute promyelocytic leukemia cells

(2017) Giedrė Valiulienė et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness

(2017) Suvasmita Rath et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors

(2017) Paola Maroni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Carbocysteine and Beclomethasone on Histone Acetylation/Deacetylation Processes in Cigarette Smoke Exposed Bronchial Epithelial Cells

(2017) Elisabetta Pace et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Correlation between histone acetylation and expression of Notch1 in human lung carcinoma and its possible role in combined small-cell lung carcinoma

(2017) Wael Abdo Hassan et al.   LABORATORY INVESTIGATION

Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

(2017) Li R. Kong et al.   Molecular Oncology

Epigenetic basis of the dark side of alcohol addiction

(2017) Subhash C. Pandey et al.   NEUROPHARMACOLOGY

PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer

(2017) Liyan Chen et al.   Oncotarget

Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: implications for COPD and lung cancer

(2016) Isaac K. Sundar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Residential neighbourhood greenspace is associated with reduced risk of incident diabetes in older people: a prospective cohort study

(2016) Alice M. Dalton et al.   BMC PUBLIC HEALTH

Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes

(2016) Irene M. Shui et al.   CANCER

Combination of panobinostat with ponatinib synergistically overcomes imatinib-resistant CML cells

(2016) Yasufumi Matsuda et al.   CANCER SCIENCE

Context Matters: Contribution of Specific DNA Adducts to the Genotoxic Properties of the Tobacco-Specific Nitrosamine NNK

(2016) Lisa A. Peterson   CHEMICAL RESEARCH IN TOXICOLOGY

Persistent Chromatin Modifications Induced by High Fat Diet

(2016) Amy Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model

(2016) Leena Hilakivi-Clarke et al.   JNCI-Journal of the National Cancer Institute

Inhibition of Class I Histone Deacetylases 1 and 2 Promotes Urothelial Carcinoma Cell Death by Various Mechanisms

(2016) M. Pinkerneil et al.   MOLECULAR CANCER THERAPEUTICS

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

(2016) Kimberly A. Krautkramer et al.   MOLECULAR CELL

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

Panobinostat-A Potential Treatment for Metastasized Ewing Sarcoma? A Case Report

(2016) Annemiek M. van Maldegem et al.   PEDIATRIC BLOOD & CANCER

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

Epigenetic silencing of p21 by long non-coding RNA HOTAIR is involved in the cell cycle disorder induced by cigarette smoke extract

(2016) Yi Liu et al.   TOXICOLOGY LETTERS

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

HEDD: the human epigenetic drug database

(2016) Yunfeng Qi et al.   Database-The Journal of Biological Databases and Curation

Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms

(2016) Joshua R Freeman et al.   Oncotarget

Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model

(2016) Leena Hilakivi-Clarke et al.   JNCI-Journal of the National Cancer Institute

Reversion of AHRR Demethylation Is a Quantitative Biomarker of Smoking Cessation

(2016) Robert Philibert et al.   Frontiers in Psychiatry

Molecular damage and lung tumors in cigarette smoke-exposed mice

(2015) Alberto Izzotti et al.   Annals of the New York Academy of Sciences

Association of Methylation of the RAR-β Gene with Cigarette Smoking in Non-Small Cell Lung Cancer with Southern-central Chinese Population

(2015) Wen Li et al.   Asian Pacific Journal of Cancer Prevention

Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases

(2015) Saman Sabounchi et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives

(2015) Philippe Grandjean et al.   ENDOCRINOLOGY

A Systematic Gene–Gene and Gene–Environment Interaction Analysis of DNA Repair GenesXRCC1,XRCC2,XRCC3,XRCC4, and Oral Cancer Risk

(2015) Cheng-Hong Yang et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Cigarette smoke mediates epigenetic repression of miR-217 during esophageal adenocarcinogenesis

(2015) S Xi et al.   ONCOGENE

Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells

(2015) Partha Mukhopadhyay et al.   REPRODUCTIVE TOXICOLOGY

A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2′-dC upon inhibition of ribonucleotide reductase

(2015) Alissa Minkovsky et al.   Epigenetics & Chromatin

Associative DNA methylation changes in children with prenatal alcohol exposure

(2015) Benjamin I Laufer et al.   Epigenomics

The Interaction between Epigenetics, Nutrition and the Development of Cancer

(2015) Karen Bishop et al.   Nutrients

Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood

(2015) Ho-Sun Lee   Nutrients

Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice

(2015) Min Wu et al.   Oncotarget

Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies

(2015) Yin Cao et al.   BMJ-British Medical Journal

Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies

(2015) Yin Cao et al.   BMJ-British Medical Journal

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer

(2015) Shujie Yang et al.   Oncotarget

Acute Ethanol Alters Multiple Histone Modifications at Model Gene Promoters in the Cerebral Cortex

(2014) Andrey Finegersh et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract

(2014) Bairu Wang et al.   ARCHIVES OF TOXICOLOGY

Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

(2014) Heli Venhoranta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of histone modifying enzymes by the ubiquitin–proteasome system

(2014) Chunbin Zou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cigarette sidestream smoke induces histone H3 phosphorylation via JNK and PI3K/Akt pathways, leading to the expression of proto-oncogenes

(2014) Yuko Ibuki et al.   CARCINOGENESIS

Hydralazine–valproate: a repositioned drug combination for the epigenetic therapy of cancer

(2014) Alfonso Dueñas-Gonzalez et al.   Expert Opinion on Drug Metabolism & Toxicology

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Paternal Alcohol Exposure Reduces Alcohol Drinking and Increases Behavioral Sensitivity to Alcohol Selectively in Male Offspring

(2014) Andrey Finegersh et al.   PLoS One

NNK, a Tobacco-Specific Carcinogen, Inhibits the Expression of Lysyl Oxidase, a Tumor Suppressor

(2014) Guang Cheng et al.   International Journal of Environmental Research and Public Health

Methylation-Associated Gene Silencing ofRARBin Areca Carcinogens Induced Mouse Oral Squamous Cell Carcinoma

(2014) Zi-Lun Lai et al.   Biomed Research International

Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma

(2013) Mariana Brait et al.   CELL CYCLE

DNA Methyltransferase Inhibition Reverses Epigenetically Embedded Phenotypes in Lung Cancer Preferentially Affecting Polycomb Target Genes

(2013) A. Hascher et al.   CLINICAL CANCER RESEARCH

A genome-wide methylation study on obesity

(2013) Xiaojing Xu et al.   Epigenetics

Cigarette Smoke Component Acrolein Modulates Chromatin Assembly by Inhibiting Histone Acetylation

(2013) Danqi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis

(2013) Sichuan Xi et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes

(2013) Xiaolu Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Cigarette Smoke Induces Distinct Histone Modifications in Lung Cells: Implications for the Pathogenesis of COPD and Lung Cancer

(2013) Isaac K. Sundar et al.   JOURNAL OF PROTEOME RESEARCH

High expressions of histone methylation- and phosphorylation-related proteins are associated with prognosis of oral squamous cell carcinoma in male population of Taiwan

(2013) Jen-Hao Chen et al.   MEDICAL ONCOLOGY

Correction: Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells

(2013) Sascha Venturelli et al.   PLoS One

Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells

(2013) Han Han et al.   PLoS One

Cigarette smoking and DNA methylation

(2013) Ken W. K. Lee et al.   Frontiers in Genetics

Distinct Involvement of 9p21-24 and 13q14.1-14.3 Chromosomal Regions in Raw Betel-Nut Induced Esophageal Cancers in the State of Meghalaya, India

(2012) Avdhesh K. Rai et al.   Asian Pacific Journal of Cancer Prevention

Genome-Wide miRNA Expression Profiling Identifies miR-9-3 and miR-193a as Targets for DNA Methylation in Non-Small Cell Lung Cancers

(2012) G. Heller et al.   CLINICAL CANCER RESEARCH

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Epigenetic Inheritance of Disease and Disease Risk

(2012) Johannes Bohacek et al.   NEUROPSYCHOPHARMACOLOGY

Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes

(2012) Hui-wen Liu et al.   NUCLEIC ACIDS RESEARCH

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

ArecolineN-Oxide: Its Mutagenicity and Possible Role as Ultimate Carcinogen in Areca Oral Carcinogenesis

(2011) Kuo-Hui Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cytotoxic Effects Produced by Arecoline Correlated to Epigenetic Regulation in Human K-562 Cells

(2011) Pei-Chin Lin et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Epigenome-wide association studies for common human diseases

(2011) Vardhman K. Rakyan et al.   NATURE REVIEWS GENETICS

MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer

(2011) Robert S. Hudson et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

(2011) Johannes Gräff et al.   PHYSIOLOGICAL REVIEWS

Epigenetic diet: impact on the epigenome and cancer

(2011) Tabitha M Hardy et al.   Epigenomics

Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke: An Overview

(2011) Rong-Jane Chen et al.   Journal of Oncology

Endothelin Receptor Type B Gene Promoter Hypermethylation in Salivary Rinses Is Independently Associated with Risk of Oral Cavity Cancer and Premalignancy

(2010) K. M. Pattani et al.   Cancer Prevention Research

Nitric Oxide-Mediated Histone Hyperacetylation in Oral Cancer: Target for a Water-Soluble HAT Inhibitor, CTK7A

(2010) Mohammed Arif et al.   CHEMISTRY & BIOLOGY

Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer

(2010) D. Beleford et al.   CLINICAL CANCER RESEARCH

Promoter hypermethylation in Indian primary oral squamous cell carcinoma

(2010) Jatinder Kaur et al.   INTERNATIONAL JOURNAL OF CANCER

High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka

(2010) Maiko Takeshima et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis

(2010) Karwan A Moutasim et al.   JOURNAL OF PATHOLOGY

Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

(2010) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate

(2010) F Liu et al.   ONCOGENE

Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma

(2010) Sung-Hsien Huang et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

(2009) M. E. Figueroa et al.   BLOOD

Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells

(2009) Hongjuan Zhao et al.   BMC Medical Genomics

Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-Sensitive and Castrate-Resistant Prostate Cancer

(2009) D. S. Welsbie et al.   CANCER RESEARCH

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells

(2009) F. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Lung cancer epigenetics and genetics

(2008) Angela Risch et al.   INTERNATIONAL JOURNAL OF CANCER

Histone Ubiquitination: Triggering Gene Activity

(2008) Vikki M. Weake et al.   MOLECULAR CELL

A novel single nucleotide polymorphism in XRCC4 gene is associated with oral cancer susceptibility in Taiwanese patients

(2008) Chang-Fang Chiu et al.   ORAL ONCOLOGY

Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients

(2008) Hao-Hueng Chang et al.   ORAL ONCOLOGY

Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cells

(2008) Yi-Shan Tsai et al.   TOXICOLOGY

CpG island density and its correlations with genomic features in mammalian genomes

(2008) Leng Han et al.   GENOME BIOLOGY