Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors

Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma

(2017) Paola Bendinelli et al.   Cell Death & Disease

The hypoxic tumor microenvironment: A driving force for breast cancer progression

(2016) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma

(2016) S. Del Mare et al.   CANCER RESEARCH

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

DNA methylation plasticity contributes to the natural history of metastasis

(2015) Miguel Vizoso et al.   CELL CYCLE

Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion

(2015) Nikola Vlahov et al.   CURRENT BIOLOGY

Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear translocation in bone metastasis from breast carcinoma

(2015) Paola Maroni et al.   EXPERIMENTAL CELL RESEARCH

Tumor suppressor WWOX moderates the mitochondrial respiratory complex

(2015) Amanda Choo et al.   GENES CHROMOSOMES & CANCER

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Hypoxia-inducible factor 1 and breast cancer metastasis

(2015) Zhao-ji Liu et al.   Journal of Zhejiang University-SCIENCE B

HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells

(2015) Paola Bendinelli et al.   Molecular Cancer

Epigenetic and Genetic Alterations Affect the WWOX Gene in Head and Neck Squamous Cell Carcinoma

(2015) Seda Ekizoglu et al.   PLoS One

Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics

(2015) Prashanta Kumar Panda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies

(2014) C. Marcelo Aldaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation

(2014) M Abu-Remaileh et al.   CELL DEATH AND DIFFERENTIATION

Very large common fragile site genes and their potential role in cancer development

(2014) Ge Gao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

(2014) Veronica A. Codelia et al.   CURRENT BIOLOGY

WW domain-containing oxidoreductase’s role in myriad cancers: Clinical significance and future implications

(2014) Aliza Gardenswartz et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

WWOX: A fragile tumor suppressor

(2014) Morgan S Schrock et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism

(2014) Muhannad Abu-Remaileh et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Association study of a functional copy number variation in theWWOXgene with risk of gliomas among Chinese people

(2014) Ke Yu et al.   INTERNATIONAL JOURNAL OF CANCER

Clinical development of demethylating agents in hematology

(2014) Shyamala C. Navada et al.   JOURNAL OF CLINICAL INVESTIGATION

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2014) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer

(2013) Paola Bendinelli et al.   EUROPEAN JOURNAL OF CANCER

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese

(2013) Lei Yang et al.   HUMAN MOLECULAR GENETICS

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

A RASSF1A Polymorphism Restricts p53/p73 Activation and Associates with Poor Survival and Accelerated Age of Onset of Soft Tissue Sarcoma

(2012) K. S. Yee et al.   CANCER RESEARCH

Bone metastatic process of breast cancer involves methylation state affecting E-cadherin expression through TAZ and WWOX nuclear effectors

(2012) Emanuela Matteucci et al.   EUROPEAN JOURNAL OF CANCER

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase

(2011) Jean-Yun Chang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nuclear co-localization and functional interaction of COX-2 and HIF-1α characterize bone metastasis of human breast carcinoma

(2010) Paola Maroni et al.   BREAST CANCER RESEARCH AND TREATMENT

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Modularity in the Hippo signaling pathway

(2010) Marius Sudol et al.   TRENDS IN BIOCHEMICAL SCIENCES

YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

(2009) Kainan Wang et al.   Biochemistry and Cell Biology

Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells

(2009) E. Matteucci et al.   CARCINOGENESIS

Transforming Growth Factor β1 Signaling via Interaction with Cell Surface Hyal-2 and Recruitment of WWOX/WOX1

(2009) Li-Jin Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WWOX: Its genomics, partners, and functions

(2009) Sara Del Mare et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nuclear Accumulation of E-Cadherin Correlates with Loss of Cytoplasmic Membrane Staining and Invasion in Pituitary Adenomas

(2009) Marianne S. Elston et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Complement C1q Activates Tumor Suppressor WWOX to Induce Apoptosis in Prostate Cancer Cells

(2009) Qunying Hong et al.   PLoS One

Dramatic Co-Activation of WWOX/WOX1 with CREB and NF-κB in Delayed Loss of Small Dorsal Root Ganglion Neurons upon Sciatic Nerve Transection in Rats

(2009) Meng-Yen Li et al.   PLoS One

E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas

(2008) Alan Wells et al.   CLINICAL & EXPERIMENTAL METASTASIS

MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1

(2008) Chen-Peng Lo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

(2008) Rami I. Aqeilan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

(2008) Dimitrios Iliopoulos et al.   PLoS One