Epigenetic Inheritance of Disease and Disease Risk

Minireview: Epigenetic Programming of Diabetes and Obesity: Animal Models

(2012) Yoshinori Seki et al.   ENDOCRINOLOGY

Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence

(2012) I. Ponomarev et al.   JOURNAL OF NEUROSCIENCE

Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint

(2012) Sam Guoping Gu et al.   NATURE GENETICS

The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment

(2012) J. E. Cropley et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Critical Evaluation of Imprinted Gene Expression by RNA–Seq: A New Perspective

(2012) Brian DeVeale et al.   PLoS Genetics

Paternal Transmission of Stress-Induced Pathologies

(2011) David M. Dietz et al.   BIOLOGICAL PSYCHIATRY

Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans

(2011) Oded Rechavi et al.   CELL

Epigenetic mechanisms in developmental programming of adult disease

(2011) Man Chen et al.   DRUG DISCOVERY TODAY

The impact of epigenomics on future drug design and new therapies

(2011) Christopher A. Hamm et al.   DRUG DISCOVERY TODAY

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

Variable histone modifications at the Avymetastable epiallele

(2011) Dana C. Dolinoy et al.   Epigenetics

A survey of small RNAs in human sperm

(2011) Stephen A. Krawetz et al.   HUMAN REPRODUCTION

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

(2011) C. P. Morgan et al.   JOURNAL OF NEUROSCIENCE

Cleavage of rRNA ensures translational cessation in sperm at fertilization

(2011) G.D. Johnson et al.   MOLECULAR HUMAN REPRODUCTION

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

Transcriptional and epigenetic mechanisms of addiction

(2011) Alfred J. Robison et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic Treatments for Cognitive Impairments

(2011) Jeremy J Day et al.   NEUROPSYCHOPHARMACOLOGY

Influence of Early Stress on Social Abilities and Serotonergic Functions across Generations in Mice

(2011) Tamara B. Franklin et al.   PLoS One

Dietary Protein Restriction during F0 Pregnancy in Rats Induces Transgenerational Changes in the Hepatic Transcriptome in Female Offspring

(2011) Samuel P. Hoile et al.   PLoS One

miR-135A Regulates Preimplantation Embryo Development through Down-Regulation of E3 Ubiquitin Ligase Seven in Absentia Homolog 1A (SIAH1A) Expression

(2011) Ronald T. K. Pang et al.   PLoS One

Sperm-borne microRNA-34c is required for the first cleavage division in mouse

(2011) W.-M. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

(2011) Khursheed Iqbal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of maternal diet on the epigenome: implications for human metabolic disease

(2011) Karen A. Lillycrop   PROCEEDINGS OF THE NUTRITION SOCIETY

Prenatal exposure to ethanol: A specific effect on the H19 gene in sperm

(2011) Christelle Stouder et al.   REPRODUCTIVE TOXICOLOGY

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

(2011) Mark Wossidlo et al.   Nature Communications

Inheritable Effect of Unpredictable Maternal Separation on Behavioral Responses in Mice

(2011) Isabelle C. Weiss et al.   Frontiers in Behavioral Neuroscience

Chromatin Organization in Sperm May Be the Major Functional Consequence of Base Composition Variation in the Human Genome

(2011) Tanya Vavouri et al.   PLoS Genetics

Nutrition, Epigenetics, and Developmental Plasticity: Implications for Understanding Human Disease

(2010) Graham C. Burdge et al.   Annual Review of Nutrition

Developmental Origins of Health and Disease: New Insights

(2010) Mark A. Hanson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Early Life Programming and Neurodevelopmental Disorders

(2010) Tracy L. Bale et al.   BIOLOGICAL PSYCHIATRY

Histone Modifications at the Blastocyst Axin1Fu Locus Mark the Heritability of In Vitro Culture-Induced Epigenetic Alterations in Mice1

(2010) Raul Fernandez-Gonzalez et al.   BIOLOGY OF REPRODUCTION

Prenatal stress and brain development

(2010) Arnaud Charil et al.   BRAIN RESEARCH REVIEWS

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity

(2010) Elizabeth H. Bayne et al.   CELL

MicroRNA Activity Is Suppressed in Mouse Oocytes

(2010) Jun Ma et al.   CURRENT BIOLOGY

Stable inheritance of an acquired behavior in Caenorhabditis elegans

(2010) Jean-Jacques Remy   CURRENT BIOLOGY

The prevalence of epigenetic mechanisms in the regulation of cognitive functions and behaviour

(2010) Tamara B Franklin et al.   CURRENT OPINION IN NEUROBIOLOGY

Parent-of-origin and trans-generational germline influences on behavioral development: The interacting roles of mothers, fathers, and grandparents

(2010) J.P. Curley et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Transgenerational Inheritance of Glucose Intolerance in a Mouse Model of Neonatal Overnutrition

(2010) Thais Pentinat et al.   ENDOCRINOLOGY

The paternal hidden agenda: Epigenetic inheritance through sperm chromatin

(2010) Deepika Puri et al.   Epigenetics

Glucocorticoids, prenatal stress and the programming of disease

(2010) Anjanette Harris et al.   HORMONES AND BEHAVIOR

Epigenetics and chemical safety assessment

(2010) Matthew J. LeBaron et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Epigenetics as a unifying principle in the aetiology of complex traits and diseases

(2010) Arturas Petronis   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Targets and dynamics of promoter DNA methylation during early mouse development

(2010) Julie Borgel et al.   NATURE GENETICS

Next-generation genomics: an integrative approach

(2010) R. David Hawkins et al.   NATURE REVIEWS GENETICS

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

(2010) Julie A. Law et al.   NATURE REVIEWS GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Timing in Prenatal Nutrition: A Reprise of the Dutch Famine Study

(2010) Mervyn Susser et al.   NUTRITION REVIEWS

Review: Placental Programming of Postnatal Diabetes and Impaired Insulin Action after IUGR

(2010) K.L. Gatford et al.   PLACENTA

Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome

(2010) Carlos Guerrero-Bosagna et al.   PLoS One

Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes

(2010) Christelle Stouder et al.   REPRODUCTION

The sperm nucleus: chromatin, RNA, and the nuclear matrix

(2010) Graham D Johnson et al.   REPRODUCTION

Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations

(2010) Kaylon L. Bruner-Tran et al.   REPRODUCTIVE TOXICOLOGY

Paramutation’s Properties and Puzzles

(2010) Vicki L. Chandler   SCIENCE

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

Epigenetic Reprogramming in Plant and Animal Development

(2010) Suhua Feng et al.   SCIENCE

Developmental origins of metabolic disease: life course and intergenerational perspectives

(2010) Keith M. Godfrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transgenerational genetic effects of the paternal Y chromosome on daughters’ phenotypes

(2010) Vicki R Nelson et al.   Epigenomics

Maternal Ethanol Consumption Alters the Epigenotype and the Phenotype of Offspring in a Mouse Model

(2010) Nina Kaminen-Ahola et al.   PLoS Genetics

Foetal Alcohol Spectrum Disorders and Alterations in Brain and Behaviour

(2009) C. Guerri et al.   ALCOHOL AND ALCOHOLISM

Effect of Alcohol Consumption on CpG Methylation in the Differentially Methylated Regions ofH19andIG-DMRin Male Gametes-Implications for Fetal Alcohol Spectrum Disorders

(2009) Lillian A. Ouko et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

(2009) Tania L. Roth et al.   BIOLOGICAL PSYCHIATRY

Animal Models to Study Environmental Epigenetics1

(2009) Cheryl S. Rosenfeld   BIOLOGY OF REPRODUCTION

Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta

(2009) K. O’Donnell et al.   DEVELOPMENTAL NEUROSCIENCE

Neonatal Exposure to Diethylstilbestrol Alters Expression of DNA Methyltransferases and Methylation of Genomic DNA in the Mouse Uterus

(2009) Koji SATO et al.   ENDOCRINE JOURNAL

Maternal High-Fat Diet Promotes Body Length Increases and Insulin Insensitivity in Second-Generation Mice

(2009) Gregory A. Dunn et al.   ENDOCRINOLOGY

Hypermethylation of Homeobox A10 byin UteroDiethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming

(2009) Jason G. Bromer et al.   ENDOCRINOLOGY

Epigenetic dysregulation in cognitive disorders

(2009) Johannes Gräff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transgenerational genetic effects on phenotypic variation and disease risk

(2009) J. H. Nadeau   HUMAN MOLECULAR GENETICS

Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment

(2009) J. A. Arai et al.   JOURNAL OF NEUROSCIENCE

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Impairment in protein expression profile of testicular steroid receptor coregulators in male rat offspring perinatally exposed to Bisphenol A

(2009) Smita Salian et al.   LIFE SCIENCES

Imprinting and epigenetic changes in the early embryo

(2009) Jamie R. Weaver et al.   MAMMALIAN GENOME

Paramutation: A Heritable Change in Gene Expression by Allelic Interactions In Trans

(2009) Maike Stam   Molecular Plant

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Small silencing RNAs: an expanding universe

(2009) Megha Ghildiyal et al.   NATURE REVIEWS GENETICS

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic inheritance in mammals: Evidence for the impact of adverse environmental effects

(2009) Tamara B. Franklin et al.   NEUROBIOLOGY OF DISEASE

Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

(2009) William Renthal et al.   NEURON

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

(2009) Eva Jablonka et al.   QUARTERLY REVIEW OF BIOLOGY

Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm

(2009) Christelle Stouder et al.   REPRODUCTION

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Assisted Reproductive Technology, Epigenetics, and Long-Term Health: A Developmental Time Bomb Still Ticking

(2009) Kristen Grace et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of subsequent generations

(2009) Kunifumi Inawaka et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Paramutation: the tip of an epigenetic iceberg?

(2009) Catherine M. Suter et al.   TRENDS IN GENETICS

Emerging Role of Epigenetics in the Actions of Alcohol

(2008) Shivendra D. Shukla et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

A Mechanistic View of Genomic Imprinting

(2008) Ky Sha   Annual Review of Genomics and Human Genetics

Transgenerational Epigenetic Effects

(2008) Neil A. Youngson et al.   Annual Review of Genomics and Human Genetics

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring

(2008) Karen A. Lillycrop et al.   BRITISH JOURNAL OF NUTRITION

The Colorful History of Active DNA Demethylation

(2008) Steen K.T. Ooi et al.   CELL

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

(2008) J. C. Jimenez-Chillaron et al.   DIABETES

The EDGE hypothesis: Epigenetically directed genetic errors in repeat-containing proteins (RCPs) involved in evolution, neuroendocrine signaling, and cancer

(2008) Douglas M. Ruden et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Epigenetic mechanisms and the transgenerational effects of maternal care

(2008) Frances A. Champagne   FRONTIERS IN NEUROENDOCRINOLOGY

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER

Paternal contributions: New functional insights for spermatozoal RNA

(2008) Claudia Lalancette et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

(2008) Ho-Jin Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

(2008) B. R. Mueller et al.   JOURNAL OF NEUROSCIENCE

Maternal, not paternal, PTSD is related to increased risk for PTSD in offspring of Holocaust survivors

(2008) Rachel Yehuda et al.   JOURNAL OF PSYCHIATRIC RESEARCH

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior

(2008) Michael K. Skinner et al.   PLoS One

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The link between childhood trauma and depression: Insights from HPA axis studies in humans

(2008) Christine Heim et al.   PSYCHONEUROENDOCRINOLOGY

Vinclozolin—The lack of a transgenerational effect after oral maternal exposure during organogenesis

(2008) S SCHNEIDER et al.   REPRODUCTIVE TOXICOLOGY

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE