Gene-Diet Interaction and Precision Nutrition in Obesity

Gene–obesogenic environment interactions in the UK Biobank study

(2017) Jessica Tyrrell et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Adherence to Healthy Lifestyle and Cardiovascular Diseases in the Chinese Population

(2017) Jun Lv et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents

(2017) Jie-Yun Song et al.   PLoS One

Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects study

(2017) Lena M S Carlsson et al.   Lancet Diabetes & Endocrinology

Long-term Impact of Temporal Sequence from Childhood Obesity to Hyperinsulinemia on Adult Metabolic Syndrome and Diabetes: The Bogalusa Heart Study

(2017) Tao Zhang et al.   Scientific Reports

Heritability of high sugar consumption through drinks and the genetic correlation with substance use

(2016) Jorien L Treur et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Interactions between genetic variants associated with adiposity traits and soft drinks in relation to longitudinal changes in body weight and waist circumference

(2016) Nanna J Olsen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts

(2016) Louise Brunkwall et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

(2016) Tao Huang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sugar-sweetened beverage intake, chromosome 9p21 variants, and risk of myocardial infarction in Hispanics

(2016) Yan Zheng et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials1–3

(2016) Yan Zheng et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Determinants and Consequences of Obesity

(2016) Adela Hruby et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Relationship Among Body Fat Percentage, Body Mass Index, and All-Cause Mortality

(2016) Raj Padwal et al.   ANNALS OF INTERNAL MEDICINE

Putting the Genome in Context: Gene-Environment Interactions in Type 2 Diabetes

(2016) Paul W. Franks et al.   Current Diabetes Reports

Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program

(2016) Geoffrey A. Walford et al.   DIABETES

Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial

(2016) Yoriko Heianza et al.   DIABETES CARE

Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis

(2016) Marta Guasch-Ferré et al.   DIABETES CARE

Temporal Relationship Between Childhood Body Mass Index and Insulin and Its Impact on Adult HypertensionNovelty and Significance

(2016) Tao Zhang et al.   HYPERTENSION

Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial

(2016) W Ma et al.   INTERNATIONAL JOURNAL OF OBESITY

Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS LOST trial

(2016) T Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Association of a Genetic Risk Score With Body Mass Index Across Different Birth Cohorts

(2016) Stefan Walter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic variations of circulating adiponectin levels modulate changes in appetite in response to weight-loss diets

(2016) Wenjie Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets

(2016) Yan Zheng et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Weight-Loss Diets, Adiponectin, and Changes in Cardiometabolic Risk in the 2-Year POUNDS Lost Trial

(2016) Wenjie Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The long-term prognosis of cardiovascular disease and all-cause mortality for metabolically healthy obesity: a systematic review and meta-analysis

(2016) Ruizhi Zheng et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

The effect of host genetics on the gut microbiome

(2016) Marc Jan Bonder et al.   NATURE GENETICS

Association of host genome with intestinal microbial composition in a large healthy cohort

(2016) Williams Turpin et al.   NATURE GENETICS

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

(2016) Janina S. Ried et al.   Nature Communications

Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

(2016) Alexander I. Young et al.   Nature Communications

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

(2016) Tuomas O. Kilpeläinen et al.   Nature Communications

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

(2016) Johannes Kettunen et al.   Nature Communications

FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

(2016) Katherine M Livingstone et al.   BMJ-British Medical Journal

Lifestyle Advice Combined with Personalized Estimates of Genetic or Phenotypic Risk of Type 2 Diabetes, and Objectively Measured Physical Activity: A Randomized Controlled Trial

(2016) Job G. Godino et al.   PLOS MEDICINE

FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

(2016) Katherine M Livingstone et al.   BMJ-British Medical Journal

Neuropeptide Y genotype, central obesity, and abdominal fat distribution: the POUNDS LOST trial1,2

(2015) Xiaochen Lin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Normal-Weight Central Obesity: Implications for Total and Cardiovascular Mortality

(2015) Karine R. Sahakyan et al.   ANNALS OF INTERNAL MEDICINE

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

(2015) Qibin Qi et al.   DIABETES

Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits

(2015) Hassan S. Dashti et al.   DIABETES CARE

Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial

(2015)   DIABETOLOGIA

Vitamin D metabolism-related genetic variants, dietary protein intake and improvement of insulin resistance in a 2 year weight-loss trial: POUNDS Lost

(2015) Qibin Qi et al.   DIABETOLOGIA

Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

(2015) Jennifer A. Nettleton et al.   HUMAN MOLECULAR GENETICS

Metabolically normal obese people are protected from adverse effects following weight gain

(2015) Elisa Fabbrini et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial

(2015) Min Xu et al.   JOURNAL OF NUTRITION

Dietary Fat Modifies the Effects of FTO Genotype on Changes in Insulin Sensitivity

(2015) Yan Zheng et al.   JOURNAL OF NUTRITION

Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium

(2015) Caren E. Smith et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A Metabolomic Approach to Understanding the Metabolic Link between Obesity and Diabetes

(2015) Seokjae Park et al.   MOLECULES AND CELLS

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Food Preference Patterns in a UK Twin Cohort

(2015) Tess Pallister et al.   Twin Research and Human Genetics

Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses

(2015) Ayşe Demirkan et al.   PLoS Genetics

Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood

(2015) Ralph Burkhardt et al.   PLoS Genetics

FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial

(2014) Tao Huang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Beyond BMI: The “Metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review

(2014) Lara L Roberson et al.   BMC PUBLIC HEALTH

Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?

(2014) George A. Bray et al.   DIABETES CARE

PCSK7Genotype Modifies Effect of a Weight-Loss Diet on 2-Year Changes of Insulin Resistance: The POUNDS LOST Trial

(2014) Tao Huang et al.   DIABETES CARE

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

(2014) Z. Wang et al.   EUROPEAN HEART JOURNAL

FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

(2014) Qibin Qi et al.   HUMAN MOLECULAR GENETICS

Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study

(2014) R Foraita et al.   INTERNATIONAL JOURNAL OF OBESITY

Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults

(2014) Bradley C. Johnston et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabolically Healthy Obesity, Presence or Absence of Fatty Liver, and Risk of Type 2 Diabetes in Japanese Individuals: Toranomon Hospital Health Management Center Study 20 (TOPICS 20)

(2014) Yoriko Heianza et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CETPgenotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials

(2014) Qibin Qi et al.   JOURNAL OF LIPID RESEARCH

Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies

(2014) J. A. Bell et al.   Obesity Reviews

The Effects of Genetic Variation in FTO rs9939609 on Obesity and Dietary Preferences in Chinese Han Children and Adolescents

(2014) Min Yang et al.   PLoS One

Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies

(2014) Q. Qi et al.   BMJ-British Medical Journal

Saturated Fat Intake Modulates the Association between an Obesity Genetic Risk Score and Body Mass Index in Two US Populations

(2014) Patricia Casas-Agustench et al.   Journal of the Academy of Nutrition and Dietetics

Long-term Outcomes of Bariatric Surgery

(2014) Anita P. Courcoulas et al.   JAMA Surgery

Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery

(2014) Sten Madsbad et al.   Lancet Diabetes & Endocrinology

Variants in glucose- and circadian rhythm–related genes affect the response of energy expenditure to weight-loss diets: the POUNDS LOST Trial

(2013) Khadijeh Mirzaei et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

(2013) Toshiko Tanaka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis

(2013) Vasanti S Malik et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Weight Loss after Gastric Bypass Is Associated with a Variant at 15q26.1

(2013) Ida J. Hatoum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Are Metabolically Healthy Overweight and Obesity Benign Conditions?

(2013) Caroline K. Kramer et al.   ANNALS OF INTERNAL MEDICINE

Genetic Determinant for Amino Acid Metabolites and Changes in Body Weight and Insulin Resistance in Response to Weight-Loss Diets

(2013) Min Xu et al.   CIRCULATION

Gene–diet interaction and weight loss

(2013) Lu Qi   CURRENT OPINION IN LIPIDOLOGY

FTO Genotype, Vitamin D Status, and Weight Gain During Childhood

(2013) B. H. Lourenco et al.   DIABETES

IRS1 Genotype Modulates Metabolic Syndrome Reversion in Response to 2-Year Weight-Loss Diet Intervention: The POUNDS LOST trial

(2013) Q. Qi et al.   DIABETES CARE

Novel locus including FGF21 is associated with dietary macronutrient intake

(2013) Audrey Y. Chu et al.   HUMAN MOLECULAR GENETICS

Genome-wide Association of Single-Nucleotide Polymorphisms With Weight Loss Outcomes After Roux-en-Y Gastric Bypass Surgery

(2013) Erica S. Rinella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interactions of genetic and environmental risk factors with respect to body fat mass in children: Results from the ALSPAC study

(2013) Christina Riedel et al.   Obesity

The genomic determinants of genotype × environment interactions in gene expression

(2013) Vladislav Grishkevich et al.   TRENDS IN GENETICS

Dietary sugars and body weight: systematic review and meta-analyses of randomised controlled trials and cohort studies

(2013) L. Te Morenga et al.   BMJ-British Medical Journal

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

(2013) Shafqat Ahmad et al.   PLoS Genetics

Weight-loss diets modify glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the Preventing Overweight Using Novel Dietary Strategies trial

(2012) Qibin Qi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial

(2012) Xiaomin Zhang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention

(2012) Josiemer Mattei et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Television Watching, Leisure Time Physical Activity, and the Genetic Predisposition in Relation to Body Mass Index in Women and Men

(2012) Qibin Qi et al.   CIRCULATION

Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans

(2012) Susan Cheng et al.   CIRCULATION

FTO Genotype and 2-Year Change in Body Composition and Fat Distribution in Response to Weight-Loss Diets: The POUNDS LOST Trial

(2012) X. Zhang et al.   DIABETES

Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women

(2012) P. Wurtz et al.   DIABETES CARE

Neuropeptide Y Promoter Polymorphism Modifies Effects of a Weight-Loss Diet on 2-Year Changes of Blood Pressure

(2012) Xiaomin Zhang et al.   HYPERTENSION

Dysfunctional Adiposity and the Risk of Prediabetes and Type 2 Diabetes in Obese Adults

(2012) Ian J. Neeland et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome-wide association studies of obesity and metabolic syndrome

(2012) Tove Fall et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

(2012) Robert A Scott et al.   NATURE GENETICS

Sugar-Sweetened Beverages and Genetic Risk of Obesity

(2012) Qibin Qi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Insulin Receptor Substrate 1 Gene Variation Modifies Insulin Resistance Response to Weight-Loss Diets in a 2-Year Randomized Trial

(2011) Qibin Qi et al.   CIRCULATION

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Heritability of the Weight Loss Response to Gastric Bypass Surgery

(2011) Ida J. Hatoum et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China

(2010) Bo Xi et al.   BMC Medical Genetics

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Association of the LCT-13910C>T Polymorphism With Obesity and Its Modulation by Dairy Products in a Mediterranean Population

(2010) Dolores Corella et al.   Obesity

APOA2, Dietary Fat, and Body Mass Index

(2009) Dolores Corella   ARCHIVES OF INTERNAL MEDICINE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

(2009) Johan Rung et al.   NATURE GENETICS

Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

(2009) Frank M. Sacks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Characterization of Metabolically Benign Obesity in Humans

(2008) Norbert Stefan   ARCHIVES OF INTERNAL MEDICINE

'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents

(2008) Timo D Müller et al.   BMC Medical Genetics

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

An Obesity-AssociatedFTOGene Variant and Increased Energy Intake in Children

(2008) Joanne E. Cecil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet

(2008) Iris Shai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene-environment interaction and obesity

(2008) Lu Qi et al.   NUTRITION REVIEWS