期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/ijms18040787
关键词
gene-diet interactions; weight loss; obesity
资金
- NIH from the National Heart, Lung, and Blood Institute [HL071981, HL034594, HL126024]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK091718, DK100383, DK078616]
- Boston Obesity Nutrition Research Center [DK46200]
- United States-Israel Binational Science Foundation [2011036]
- American Heart Association [0730094N]
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [14J30007] Funding Source: KAKEN
The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epidemic. Growing studies have found that changes in adiposity and metabolic response to low-calorie weight loss diets might be modified by genetic variants related to obesity, metabolic status and preference to nutrients. This review summarized data from recent studies of gene-diet interactions, and discussed integration of research of metabolomics and gut microbiome, as well as potential application of the findings in precision nutrition.
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