The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models

Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders

(2016) Ki Chan Kim et al.   Biomolecules & Therapeutics

Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling

(2016) V.M. Doenni et al.   BRAIN BEHAVIOR AND IMMUNITY

The CB2 receptor and its role as a regulator of inflammation

(2016) Caroline Turcotte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid

(2016) Daniel M. Kerr et al.   PHARMACOLOGICAL RESEARCH

Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders

(2016) Fabio Arturo Iannotti et al.   PROGRESS IN LIPID RESEARCH

Genetic and non-genetic animal models for autism spectrum disorders (ASD)

(2016) Zivanit Ergaz et al.   REPRODUCTIVE TOXICOLOGY

Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid

(2016) M Servadio et al.   Translational Psychiatry

Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model

(2016) Maria Gomis-González et al.   Genes

Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome

(2015) Mei Qin et al.   BEHAVIOURAL BRAIN RESEARCH

Modeling autism-relevant behavioral phenotypes in rats and mice

(2015) Michela Servadio et al.   BEHAVIOURAL PHARMACOLOGY

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism

(2015) K. M. Huber et al.   JOURNAL OF NEUROSCIENCE

Autism Spectrum Disorders: Translating human deficits into mouse behavior

(2015) E. Pasciuto et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The Endocannabinoid System and its Modulation by Phytocannabinoids

(2015) Vincenzo Di Marzo et al.   Neurotherapeutics

Increased Cortical Inhibition in Autism-Linked Neuroligin-3R451C Mice Is Due in Part to Loss of Endocannabinoid Signaling

(2015) Haley E. Speed et al.   PLoS One

Endocannabinoid signaling mediates oxytocin-driven social reward

(2015) Don Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prenatal factors associated with autism spectrum disorder (ASD)

(2015) A. Ornoy et al.   REPRODUCTIVE TOXICOLOGY

Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority

(2015) Alycia K Halladay et al.   Molecular Autism

Exploring the Validity of Valproic Acid Animal Model of Autism

(2015) Darine Froy N. Mabunga et al.   Experimental Neurobiology

Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

(2014) Christopher Lipina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The molecular interplay between endocannabinoid and neurotrophin signals in the nervous system and beyond

(2014) Erik Keimpema et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Familial Risk of Autism

(2014) Sven Sandin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages

(2014) Dario Siniscalco et al.   Journal of Neuroinflammation

Endocannabinoids in Synaptic Plasticity and Neuroprotection

(2014) Jian-Yi Xu et al.   NEUROSCIENTIST

Late onset deficits in synaptic plasticity in the valproic acid rat model of autism

(2014) Henry G. S. Martin et al.   Frontiers in Cellular Neuroscience

GABAergic Signaling as Therapeutic Target for Autism Spectrum Disorders

(2014) Giada Cellot et al.   Frontiers in Pediatrics

Alterations in the endocannabinoid system in the rat valproic acid model of autism

(2013) D.M. Kerr et al.   BEHAVIOURAL BRAIN RESEARCH

Modulating the endocannabinoid system in human health and disease - successes and failures

(2013) Pál Pacher et al.   FEBS Journal

Autism

(2013) Meng-Chuan Lai et al.   LANCET

Targeting the endocannabinoid system in the treatment of fragile X syndrome

(2013) Arnau Busquets-Garcia et al.   NATURE MEDICINE

Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling

(2013) Csaba Földy et al.   NEURON

In utero exposure to valproic acid and autism — A current review of clinical and animal studies

(2013) Florence I. Roullet et al.   NEUROTOXICOLOGY AND TERATOLOGY

The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex

(2013) Stephanie M. McTighe et al.   PLoS One

Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism

(2012) Natalia V. Malkova et al.   BRAIN BEHAVIOR AND IMMUNITY

Endocannabinoids in Amygdala and Nucleus Accumbens Mediate Social Play Reward in Adolescent Rats

(2012) V. Trezza et al.   JOURNAL OF NEUROSCIENCE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

(2012) Kwang-Mook Jung et al.   Nature Communications

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

(2011) Joachim Hallmayer   ARCHIVES OF GENERAL PSYCHIATRY

Consequences of Cannabinoid and Monoaminergic System Disruption in a Mouse Model of Autism Spectrum Disorders

(2011) E. S. Onaivi et al.   Current Neuropharmacology

The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives

(2011) Eva M Marco et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Modeling Autistic Features in Animals

(2011) PAUL H. PATTERSON   PEDIATRIC RESEARCH

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function

(2011) M. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces

(2011) Bhismadev Chakrabarti et al.   Molecular Autism

Activation of the maternal immune system induces endocrine changes in the placenta via IL-6

(2010) Elaine Y. Hsiao et al.   BRAIN BEHAVIOR AND IMMUNITY

Endocannabinoid signalling: has it got rhythm?

(2010) Linda K Vaughn et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR55: Current Knowledge and Future Perspectives of a Purported “Type-3” Cannabinoid Receptor

(2010) A. Moriconi et al.   CURRENT MEDICINAL CHEMISTRY

From Surface to Nuclear Receptors: The Endocannabinoid Family Extends its Assets

(2010) M. Pistis et al.   CURRENT MEDICINAL CHEMISTRY

Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs

(2010) V. Marzo et al.   CURRENT MEDICINAL CHEMISTRY

Regulation of the Hypothalamic-Pituitary-Adrenal Axis Circadian Rhythm by Endocannabinoids Is Sexually Diergic

(2010) Helen C. Atkinson et al.   ENDOCRINOLOGY

Defective GABAergic Neurotransmission and Pharmacological Rescue of Neuronal Hyperexcitability in the Amygdala in a Mouse Model of Fragile X Syndrome

(2010) J. L. Olmos-Serrano et al.   JOURNAL OF NEUROSCIENCE

Enhanced Endocannabinoid Signaling Elevates Neuronal Excitability in Fragile X Syndrome

(2010) L. Zhang et al.   JOURNAL OF NEUROSCIENCE

Abnormal mGlu 5 Receptor/Endocannabinoid Coupling in Mice Lacking FMRP and BC1 RNA

(2010) Mauro Maccarrone et al.   NEUROPSYCHOPHARMACOLOGY

Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

(2010) Randi Hagerman et al.   Molecular Autism

The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders

(2009) Ismael Galve-Roperh et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Making synaptic plasticity and memory last: mechanisms of translational regulation

(2009) J. D. Richter et al.   GENES & DEVELOPMENT

Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit

(2009) K. Radyushkin et al.   GENES BRAIN AND BEHAVIOR

Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

(2009) Jill L Silverman et al.   NEUROPSYCHOPHARMACOLOGY

Valproic acid in pregnancy: How much are we endangering the embryo and fetus?

(2009) Asher Ornoy   REPRODUCTIVE TOXICOLOGY

Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype

(2008) Robert Benno et al.   BEHAVIOURAL BRAIN RESEARCH

Immune involvement in schizophrenia and autism: Etiology, pathology and animal models

(2008) Paul H. Patterson   BEHAVIOURAL BRAIN RESEARCH

Downregulation of Tonic GABAergic Inhibition in a Mouse Model of Fragile X Syndrome

(2008) Giulia Curia et al.   CEREBRAL CORTEX

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression

(2008) Katharina Domschke et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Divergent Effects of Anandamide Transporter Inhibitors with Different Target Selectivity on Social Play Behavior in Adolescent Rats

(2008) V. Trezza et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

(2008) S. Jamain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid

(2008) Tomasz Schneider et al.   PSYCHONEUROENDOCRINOLOGY

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES

Abnormal Striatal GABA Transmission in the Mouse Model for the Fragile X Syndrome

(2007) Diego Centonze et al.   BIOLOGICAL PSYCHIATRY

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR