Roles of Copper-Binding Proteins in Breast Cancer

Defining the human copper proteome and analysis of its expression variation in cancers

(2017) S. Blockhuys et al.   Metallomics

Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis

(2016) Thomas R. Cox et al.   CANCER RESEARCH

Predictive Outcomes for HER2-enriched Cancer Using Growth and Metastasis Signatures Driven By SPARC

(2016) Leandro N. Güttlein et al.   MOLECULAR CANCER RESEARCH

Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization

(2016) Anna Frei et al.   Oncotarget

Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin

(2016) Cristine L. Chisholm et al.   Oncotarget

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane

(2016) Meghan A. Morrissey et al.   PLoS Genetics

Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells

(2016) Danny Ramos et al.   PLoS One

Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo

(2016) Archita Das et al.   Scientific Reports

Identification of New Potential Interaction Partners for Human Cytoplasmic Copper Chaperone Atox1: Roles in Gene Regulation?

(2015) Helena Öhrvik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

(2015) Christine A. Phillips-Krawczak et al.   MOLECULAR BIOLOGY OF THE CELL

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

(2015) Jing Wang et al.   Nature Chemistry

Human Copper Chaperone Atox1 Translocates to the Nucleus but does not Bind DNA In Vitro

(2015) Dana Kahra et al.   PROTEIN AND PEPTIDE LETTERS

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

(2015) Damiano Cosimo Rigiracciolo et al.   Oncotarget

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function

(2015) Gin-Fu Chen et al.   Scientific Reports

Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition

(2015) Shun Li et al.   Scientific Reports

How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1

(2014) Helena Öhrvik et al.   Annals of the New York Academy of Sciences

Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis

(2014) G. P. Nagaraju et al.   CARCINOGENESIS

Nuclear translocation of lysyl oxidase is promoted by interaction with transcription repressor p66β

(2014) Irina A. Okkelman et al.   CELL AND TISSUE RESEARCH

Copper is a potent inhibitor of both the canonical and non-canonical NFκB pathways

(2014) Niall Kenneth et al.   CELL CYCLE

Copper as a key regulator of cell signalling pathways

(2014) Alexandra Grubman et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

A new role for LOX and LOXL2 proteins in transcription regulation

(2014) Ane Iturbide et al.   FEBS Journal

Copper is required for oncogenic BRAF signalling and tumorigenesis

(2014) Donita C. Brady et al.   NATURE

Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

(2014) G. MacDonald et al.   Science Signaling

Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury

(2013) Takashi Kohno et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients

(2013) Sung Gwe Ahn et al.   BREAST CANCER RESEARCH AND TREATMENT

MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasivein Vitro

(2013) Hee-Jung Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator of ERBB2-driven Cell Motility (MEMO) Promotes Extranuclear Estrogen Receptor Signaling Involving the Growth Factor Receptors IGF1R and ERBB2

(2013) Kai Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metals and Breast Cancer

(2013) Celia Byrne et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Determinants for Simultaneous Binding of Copper and Platinum to Human Chaperone Atox1: Hitchhiking not Hijacking

(2013) Maria E. Palm-Espling et al.   PLoS One

Bioavailable copper modulates oxidative phosphorylation and growth of tumors

(2013) S. Ishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reaction of platinum anticancer drugs and drug derivatives with a copper transporting protein, Atox1

(2012) Maria E. Palm-Espling et al.   BIOCHEMICAL PHARMACOLOGY

Role of Copper Transport Protein Antioxidant 1 in Angiotensin II–Induced Hypertension

(2012) Kiyoshi Ozumi et al.   HYPERTENSION

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

(2012) M. L. Turski et al.   MOLECULAR AND CELLULAR BIOLOGY

MEMO1, a new IRS1-interacting protein, induces epithelial–mesenchymal transition in mammary epithelial cells

(2012) A V Sorokin et al.   ONCOGENE

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

(2012) C. P. El-Haibi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in the Understanding of Mammalian Copper Transporters

(2012) Yanfang Wang et al.   Advances in Nutrition

The HIF-1-Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth

(2011) F. Pez et al.   CANCER RESEARCH

LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution

(2011) H. E. Barker et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SPARC mediates Src-induced disruption of actin cytoskeleton via inactivation of small GTPases Rho–Rac–Cdc42

(2011) Praveen Bhoopathi et al.   CELLULAR SIGNALLING

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas

(2011) Gema Moreno-Bueno et al.   EMBO Molecular Medicine

Key contribution of CPEB4-mediated translational control to cancer progression

(2011) Elena Ortiz-Zapater et al.   NATURE MEDICINE

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

(2011) M. E. Palm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COMMD1 disrupts HIF-1α/β dimerization and inhibits human tumor cell invasion

(2010) Bart van de Sluis et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteome-Wide Profiling of the MCF10AT Breast Cancer Progression Model

(2010) Lee Yee Choong et al.   PLoS One

Lysyl oxidase: a potential target for cancer therapy

(2010) Siddikuzzaman et al.   INFLAMMOPHARMACOLOGY

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells

(2009) Peter Hollosi et al.   INTERNATIONAL JOURNAL OF CANCER

Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis

(2009) Étienne Lemieux et al.   INTERNATIONAL JOURNAL OF CANCER

Memo is a cofilin-interacting protein that influences PLC 1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration

(2009) M. Meira et al.   JOURNAL OF CELL SCIENCE

Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site

(2009) Yingjie Li et al.   JOURNAL OF STRUCTURAL BIOLOGY

Tetrathiomolybdate Inhibits Copper Trafficking Proteins Through Metal Cluster Formation

(2009) H. M. Alvarez et al.   SCIENCE

SPARC: a matricellular regulator of tumorigenesis

(2009) Shanna A. Arnold et al.   Journal of Cell Communication and Signaling

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

(2008) D. Sarrio et al.   CANCER RESEARCH

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

The use of copper-lowering therapy with tetrathiomolybdate in medicine

(2008) George J Brewer   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Novel mechanism for regulation of extracellular SOD transcription and activity by copper: Role of antioxidant-1

(2008) S ITOH et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Copper Binding Domain of SPARC Mediates Cell Survivalin Vitrovia Interaction with Integrin β1 and Activation of Integrin-linked Kinase

(2008) Matt S. Weaver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Roles for Copper Metabolism in Cell Proliferation, Signaling, and Disease

(2008) Michelle L. Turski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation

(2008) Shinichi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memo–RhoA–mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells

(2008) Kossay Zaoui et al.   JOURNAL OF CELL BIOLOGY

Transcriptional regulation of the cyclin D1 gene at a glance

(2008) E. A. Klein et al.   JOURNAL OF CELL SCIENCE