Determinants for Simultaneous Binding of Copper and Platinum to Human Chaperone Atox1: Hitchhiking not Hijacking

Reaction of platinum anticancer drugs and drug derivatives with a copper transporting protein, Atox1

(2012) Maria E. Palm-Espling et al.   BIOCHEMICAL PHARMACOLOGY

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

(2012) Chiara Gabbiani et al.   CHEMICAL COMMUNICATIONS

The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin

(2012) Roohangiz Safaei et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mechanistic Basis for Overcoming Platinum Resistance Using Copper Chelating Agents

(2012) Z. D. Liang et al.   MOLECULAR CANCER THERAPEUTICS

In Vitro Thermodynamic Dissection of Human Copper Transfer from Chaperone to Target Protein

(2012) Moritz S. Niemiec et al.   PLoS One

Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila

(2011) Haiqing Hua et al.   BIOMETALS

Metal–metal bonds in biology

(2011) Paul A. Lindahl   JOURNAL OF INORGANIC BIOCHEMISTRY

Probing the Interaction of Cisplatin with the Human Copper Chaperone Atox1 by Solution and In-Cell NMR Spectroscopy

(2011) Fabio Arnesano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

(2011) M. E. Palm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmetalation Supported by a PtIICuI Bond

(2010) Marc-Etienne Moret et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cisplatin resistance: Preclinical findings and clinical implications

(2010) Beate Köberle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Cellular uptake and cytoplasm / DNA distribution of cisplatin and oxaliplatin and their liposomal formulation in human colorectal cancer cell HCT116

(2010) Thititip Tippayamontri et al.   INVESTIGATIONAL NEW DRUGS

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Copper Transporters and the Cellular Pharmacology of the Platinum-Containing Cancer Drugs

(2010) S. B. Howell et al.   MOLECULAR PHARMACOLOGY

The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin

(2009) Nataliya V. Dolgova et al.   BIOCHEMICAL JOURNAL

Differential Roles of Met10, Thr11, and Lys60 in Structural Dynamics of Human Copper Chaperone Atox1†

(2009) Agustina Rodriguez-Granillo et al.   BIOCHEMISTRY

Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1

(2009) Zhengyi Wu et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Lysine-60 in Copper Chaperone Atox1 Plays an Essential Role in Adduct Formation with a Target Wilson Disease Domain

(2009) Faiza Hussain et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structures of Cisplatin Bound to a Human Copper Chaperone

(2009) Amie K. Boal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal Binding Domains 3 and 4 of the Wilson Disease Protein: Solution Structure and Interaction with the Copper(I) Chaperone HAH1†‡

(2008) Lucia Banci et al.   BIOCHEMISTRY

Effects of the loss of Atox1 on the cellular pharmacology of cisplatin

(2008) Roohangiz Safaei et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mononuclear Organometallic Platinum(II) Complexes and Platinum(II)−Copper(I) Mixed Complexes from Symmetrical 3,5-Bis(iminoacetyl)pyrazolate Ligands

(2008) Marc-Etienne Moret et al.   ORGANOMETALLICS