Regulation of Mutant p53 Protein Expression

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer

(2015) S. Stegeman et al.   ENDOCRINE-RELATED CANCER

MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells

(2015) Chen Xie et al.   FEBS LETTERS

SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma

(2015) Zheng Yun Zhang et al.   JOURNAL OF HEPATOLOGY

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

(2015) E. M. Alexandrova et al.   NATURE

Ribosomal proteins: functions beyond the ribosome

(2015) Xiang Zhou et al.   Journal of Molecular Cell Biology

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells

(2015) Yong Weon Yi et al.   Oncotarget

MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling

(2015) Cen Zhang et al.   Oncotarget

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

p53 Is Positively Regulated by miR-542-3p

(2014) Y. Wang et al.   CANCER RESEARCH

miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2

(2014) M D Jansson et al.   ONCOGENE

A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis

(2014) M Subramanian et al.   ONCOGENE

Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

(2014) Wensheng Yan et al.   PLoS One

miR-19b promotes tumor growth and metastasis via targeting TP53

(2014) Y. Fan et al.   RNA

microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network

(2014) Y. Hoffman et al.   Journal of Molecular Cell Biology

The dichotomy of p53 regulation by noncoding RNAs

(2014) Q. Deng et al.   Journal of Molecular Cell Biology

Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction

(2014) O Fortunato et al.   Cell Death & Disease

A gain-of-function mutant p53–HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress

(2014) D Li et al.   Cell Death & Disease

Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth

(2014) Z-J Ren et al.   Cell Death & Disease

ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53

(2014) Jianhong Zhang et al.   Nature Communications

Characterization of Dual PTEN and p53-Targeting MicroRNAs Identifies MicroRNA-638/Dnm2 as a Two-Hit Oncogenic Locus

(2014) Yvonne Tay et al.   Cell Reports

The role of ubiquitin modification in the regulation of p53

(2013) Andreas K. Hock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

(2013) Sue Haupt et al.   CELL CYCLE

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Mutant p53 Regulates Dicer through p63-dependent and -independent Mechanisms to Promote an Invasive Phenotype

(2013) Patricia A. J. Muller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of Tip60 by USP7 Determines the Activity of the p53-Dependent Apoptotic Pathway

(2013) Ashraf Dar et al.   MOLECULAR AND CELLULAR BIOLOGY

Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells

(2013) S Masciarelli et al.   ONCOGENE

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

(2013) W Wang et al.   Cell Death & Disease

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

(2013) Y-H Fan et al.   Cell Death & Disease

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Mutant p53 drives invasion in breast tumors through up-regulation of miR-155

(2012) P M Neilsen et al.   ONCOGENE

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer

(2012) Tingxiu Xiang et al.   PLoS One

MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame

(2012) Pooja Mandke et al.   PLoS One

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

(2012) Milena Wiech et al.   PLoS One

MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme

(2012) S.-S. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The sufficient minimal set of miRNA seed types

(2011) Daniel C. Ellwanger et al.   BIOINFORMATICS

miR-98 regulates cisplatin-induced A549 cell death by inhibiting TP53 pathway

(2011) Shuai Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure

(2011) Yiping Huang et al.   CELL CYCLE

MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function

(2011) S Donzelli et al.   CELL DEATH AND DIFFERENTIATION

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

(2011) Juhong Liu et al.   EMBO JOURNAL

Transcriptional and epigenetic regulation of the p53 tumor suppressor gene

(2011) Ricardo Saldaña-Meyer et al.   Epigenetics

miR-449 inhibits cell proliferation and is down-regulated in gastric cancer

(2011) Tony Bou Kheir et al.   Molecular Cancer

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26

(2010) Y. Zhang et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator

(2010) X Xiong et al.   ONCOGENE

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Ubiquitin-independent p53 proteasomal degradation

(2009) P Tsvetkov et al.   CELL DEATH AND DIFFERENTIATION

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

(2009) Qian Cheng et al.   EMBO JOURNAL

MicroRNA-125b is a novel negative regulator of p53

(2009) M. T.N. Le et al.   GENES & DEVELOPMENT

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53

(2008) Valentina Zuckerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of Pirh2-mediated p53 ubiquitylation

(2008) Yi Sheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-29 miRNAs activate p53 by targeting p85α and CDC42

(2008) Seong-Yeon Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PML enhances the regulation of p53 by CK1 in response to DNA damage

(2008) O Alsheich-Bartok et al.   ONCOGENE

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE