The regulation of MDM2 oncogene and its impact on human cancers

MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7

(2013) Qiang Li et al.   CANCER LETTERS

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity

(2013) V. Pant et al.   GENES & DEVELOPMENT

The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression

(2013) Altaf A Dar et al.   JNCI-Journal of the National Cancer Institute

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network

(2013) Lilyn Daftuar et al.   PLoS One

Endogenous Human MDM2-C Is Highly Expressed in Human Cancers and Functions as a p53-Independent Growth Activator

(2013) Danielle R. Okoro et al.   PLoS One

The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

(2012) Madhavsai Gajjar et al.   CANCER CELL

Small molecules that bind the Mdm2 RING stabilize and activate p53

(2012) P. Roxburgh et al.   CARCINOGENESIS

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Transcription Factor NFAT1 Activates themdm2Oncogene Independent of p53

(2012) Xu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress

(2012) L. Biderman et al.   MOLECULAR AND CELLULAR BIOLOGY

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage

(2012) Svetlana V. Khoronenkova et al.   MOLECULAR CELL

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop

(2012) J Zhang et al.   ONCOGENE

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

(2012) Z. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

(2012) B. Graves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme

(2012) S.-S. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians

(2011) Stian Knappskog et al.   CANCER CELL

Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop

(2011) G Blandino et al.   CELL DEATH AND DIFFERENTIATION

miR-605joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

(2011) Jiening Xiao et al.   EMBO JOURNAL

MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination

(2011) Xinjiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

(2011) Makoto R. Hara et al.   NATURE

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

(2011) L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay

(2011) A. G. Herman et al.   Cancer Discovery

E2F1 inhibits MDM2 expression in a p53-dependent manner

(2010) Xu Tian et al.   CELLULAR SIGNALLING

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Regulation of XIAP Translation and Induction by MDM2 following Irradiation

(2009) Lubing Gu et al.   CANCER CELL

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

(2009) Qian Cheng et al.   EMBO JOURNAL

CK1α Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability

(2009) Anne-Sophie Huart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation

(2009) Wei Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFN Regulatory Factor 8 Regulates MDM2 in Germinal Center B Cells

(2009) J. X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation

(2009) Rosario Amato et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

(2008) K Linke et al.   CELL DEATH AND DIFFERENTIATION

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

(2008) Yaara Ofir-Rosenfeld et al.   MOLECULAR CELL

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do stress-related psychosocial factors contribute to cancer incidence and survival?

(2008) Yoichi Chida et al.   Nature clinical practice. Oncology