Regulation of Chemokine Function: The Roles of GAG-Binding and Post-Translational Nitration

Structural Basis of Native CXCL7 Monomer Binding to CXCR2 Receptor N-Domain and Glycosaminoglycan Heparin

(2017) Aaron Brown et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions

(2017) Aaron Brown et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pancreatic islet inflammation: an emerging role for chemokines

(2017) J Jason Collier et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Inhibition of inflammation induced shedding of the endothelial glycocalyx with low molecular weight heparin

(2017) Herbert H. Lipowsky et al.   MICROVASCULAR RESEARCH

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Structural basis for chemokine recognition by a G protein–coupled receptor and implications for receptor activation

(2017) Joshua J. Ziarek et al.   Science Signaling

Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis

(2017) Hasan Al Faruque et al.   PLoS One

CCL2 nitration is a negative regulator of chemokine-mediated inflammation

(2017) Catriona E. Barker et al.   Scientific Reports

Oxidative Modifications of Protein Tyrosyl Residues Are Increased in Plasma of Human Subjects with Interstitial Lung Disease

(2016) Subramaniam Pennathur et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Non-Anticoagulant Fraction of Heparin Inhibits Leukocyte Diapedesis into the Lung by an Effect on Platelets

(2016) Yanira Riffo-Vasquez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

(2016) Andrew B. Kleist et al.   BIOCHEMICAL PHARMACOLOGY

Thirty Years of Saying NO

(2016) Paul M. Vanhoutte et al.   CIRCULATION RESEARCH

Chemokine binding proteins: An immunomodulatory strategy going viral

(2016) Víctor González-Motos et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mast cell glycosaminoglycans

(2016) B. Mulloy et al.   GLYCOCONJUGATE JOURNAL

Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions

(2016) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of chemokine receptors and intestinal epithelial cells in the mucosal inflammation and tolerance

(2016) Neeraja Kulkarni et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

(2016) M. A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery

(2016) Katsuhiro Nagata et al.   Journal of Trauma and Acute Care Surgery

Chemokines and Chemokine Receptors in the Development of Lupus Nephritis

(2016) Xiaofeng Liao et al.   MEDIATORS OF INFLAMMATION

Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?

(2016) Subrata Kumar Biswas   Oxidative Medicine and Cellular Longevity

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3

(2016) Wenguang G. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo

(2016) Rik Janssens et al.   Oncotarget

Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery

(2016) Katsuhiro Nagata et al.   Journal of Trauma and Acute Care Surgery

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

(2016) Kirti V. Sawant et al.   Scientific Reports

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

Glycosaminoglycan silencing by engineered CXCL12 variants

(2015) Martha Gschwandtner et al.   FEBS LETTERS

The dependence of chemokine–glycosaminoglycan interactions on chemokine oligomerization

(2015) Douglas P Dyer et al.   GLYCOBIOLOGY

Increased oxidative stress contributes to cardiomyocyte dysfunction and death in patients with Fabry disease cardiomyopathy

(2015) Cristina Chimenti et al.   HUMAN PATHOLOGY

Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies

(2015) Irina Kufareva et al.   IMMUNOLOGY AND CELL BIOLOGY

Glycosaminoglycans: Sorting determinants in intracellular protein traffic

(2015) Deyan Mihov et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CXCL1/MGSA Is a Novel Glycosaminoglycan (GAG)-binding Chemokine

(2015) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74–103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice

(2015) Vincent Vanheule et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction of Heparin Tetrasaccharides with Chemokine CCL5 Is Modulated by Sulfation Pattern and pH

(2015) Arunima Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis

(2015) A. Takahashi et al.   OSTEOARTHRITIS AND CARTILAGE

Allopurinol Protects against Ischemia/Reperfusion-Induced Injury in Rat Urinary Bladders

(2015) Ju-Hyun Shin et al.   Oxidative Medicine and Cellular Longevity

Designing a mutant CCL2-HSA chimera with high glycosaminoglycan-binding affinity and selectivity

(2015) Tanja Gerlza et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Chemokines and Glycosaminoglycans

(2015) Amanda E. I. Proudfoot   Frontiers in Immunology

Transplantation and inflammation: implications for the modification of chemokine function

(2014) Catriona E. Barker et al.   IMMUNOLOGY

Citrullination of CXCL12 Differentially Reduces CXCR4 and CXCR7 Binding with Loss of Inflammatory and Anti-HIV-1 Activity via CXCR4

(2014) S. Struyf et al.   JOURNAL OF IMMUNOLOGY

New nomenclature for atypical chemokine receptors

(2014) Françoise Bachelerie et al.   NATURE IMMUNOLOGY

Heparin fails to inhibit the leukocyte recruitment for an extended time following inflammatory stimulus

(2014) Dayse Santos Arimateia et al.   PHARMACEUTICAL BIOLOGY

The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide

(2014) Agnieszka A. Kendrick et al.   PROTEIN SCIENCE

Bias in chemokine receptor signalling

(2014) Annelien J.M. Zweemer et al.   TRENDS IN IMMUNOLOGY

Designing CXCL8-based decoy proteins with strong anti-inflammatory activityin vivo

(2013) Angelika Falsone et al.   BIOSCIENCE REPORTS

Molecular Basis of Glycosaminoglycan Heparin Binding to the Chemokine CXCL1 Dimer

(2013) Krishna Mohan Poluri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response

(2013) S. de Oliveira et al.   JOURNAL OF IMMUNOLOGY

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Mechano-sensing and transduction by endothelial surface glycocalyx: composition, structure, and function

(2013) Bingmei M. Fu et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

(2011) Barbara Molon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

(2011) Pavani Gangavarapu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

(2010) Xingfeng Bao et al.   IMMUNITY

Characterization of the Chemokine CXCL11-Heparin Interaction Suggests Two Different Affinities for Glycosaminoglycans

(2010) India C. Severin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Chemokine–Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs

(2010) Yoshi Tanino et al.   JOURNAL OF IMMUNOLOGY

Monomeric and Dimeric CXCL8 Are Both Essential for In Vivo Neutrophil Recruitment

(2010) Sandhya Thulasi Das et al.   PLoS One

Chemokines and Their Receptors in Human Renal Allotransplantation

(2010) Denise J. Lo et al.   TRANSPLANTATION

Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12

(2009) Graeme O'Boyle et al.   FASEB JOURNAL

Chemokine patterning by glycosaminoglycans and interceptors

(2009) Antal Rot   Frontiers in Bioscience-Landmark

Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation

(2009) T. Loos et al.   HAEMATOLOGICA

Differential Activation and Regulation of CXCR1 and CXCR2 by CXCL8 Monomer and Dimer

(2009) M. W. Nasser et al.   JOURNAL OF IMMUNOLOGY

A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage

(2009) Jens Bedke et al.   MOLECULAR IMMUNOLOGY

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation

(2008) T. Loos et al.   BLOOD

Kinetic Analysis of Intracellular Concentrations of Reactive Nitrogen Species

(2008) Chang Hoon Lim et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein tyrosine nitration—Functional alteration or just a biomarker?

(2008) José M. Souza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

(2008) Paul Proost et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Orchestrating the orchestrators: chemokines in control of T cell traffic

(2008) Shannon K Bromley et al.   NATURE IMMUNOLOGY

Regulation of chemokine activity by posttranslational modification

(2008) A MORTIER et al.   PHARMACOLOGY & THERAPEUTICS

Chemokine redundancy in BOS pathogenesis. A possible role also for the CC chemokines: MIP3-beta, MIP3-alpha, MDC and their specific receptors

(2007) F. Meloni et al.   TRANSPLANT IMMUNOLOGY