Aquaporins: important but elusive drug targets

Aggregation state determines the localization and function of M1– and M23–aquaporin-4 in astrocytes

(2014) Alex J. Smith et al.   JOURNAL OF CELL BIOLOGY

Clinical improvement in a patient with neuromyelitis optica following therapy with the anti-IL-6 receptor monoclonal antibody tocilizumab

(2014) Manabu Araki et al.   Modern Rheumatology

Mutations in AQP5, Encoding a Water-Channel Protein, Cause Autosomal-Dominant Diffuse Nonepidermolytic Palmoplantar Keratoderma

(2013) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human AQP1 Is a Constitutively Open Channel that Closes by a Membrane-Tension-Mediated Mechanism

(2013) Marcelo Ozu et al.   BIOPHYSICAL JOURNAL

A Small Molecule Screen Identifies Selective Inhibitors of Urea Transporter UT-A

(2013) Cristina Esteva-Font et al.   CHEMISTRY & BIOLOGY

Aquaporin Inhibition by Gold(III) Compounds: New Insights

(2013) Ana Paula Martins et al.   ChemMedChem

A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds

(2013) Benoît Bertrand et al.   DALTON TRANSACTIONS

Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia

(2013) Ryuichi Katada et al.   FASEB JOURNAL

Neuromyelitis Optica IgG Causes Placental Inflammation and Fetal Death

(2013) S. Saadoun et al.   JOURNAL OF IMMUNOLOGY

Mutation in AQP5, Encoding Aquaporin 5, Causes Palmoplantar Keratoderma Bothnia Type

(2013) Xu Cao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

AqF026 Is a Pharmacologic Agonist of the Water Channel Aquaporin-1

(2013) A. J. Yool et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site

(2013) Sören J. Wacker et al.   MOLECULAR MEMBRANE BIOLOGY

The Gating Mechanism of the Human Aquaporin 5 Revealed by Molecular Dynamics Simulations

(2013) Lorant Janosi et al.   PLoS One

Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells

(2013) Yong-Hong Huang et al.   TUMOR BIOLOGY

Discovery of Novel Human Aquaporin-1 Blockers

(2012) Daniel Seeliger et al.   ACS Chemical Biology

Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes

(2012) Sabina Jelen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody

(2012) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

In silico study of Aquaporin V: Effects and affinity of the central pore-occluding lipid

(2012) Y.B. Zhang et al.   BIOPHYSICAL CHEMISTRY

Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica

(2012) Lukmanee Tradtrantip et al.   FASEB JOURNAL

Homozygosity for aquaporin 7 G264V in three unrelated children with hyperglyceroluria and a mild platelet secretion defect

(2012) Christophe Goubau et al.   GENETICS IN MEDICINE

Neuromyelitis optica IgG does not alter aquaporin-4 water permeability, plasma membrane M1/M23 isoform content, or supramolecular assembly

(2012) Andrea Rossi et al.   GLIA

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

(2012) Puay-Wah Phuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aquaporin 2-increased renal cell proliferation is associated with cell volume regulation

(2012) Gisela Di Giusto et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Chemokine-dependent T cell migration requires aquaporin-3–mediated hydrogen peroxide uptake

(2012) Mariko Hara-Chikuma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aquaporin-4–dependent K+and water transport modeled in brain extracellular space following neuroexcitation

(2012) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Aquaporin 4 and neuromyelitis optica

(2012) Marios C Papadopoulos et al.   LANCET NEUROLOGY

Noble metal-dithiocarbamates precious allies in the fight against cancer

(2012) Eszter Márta Nagy et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Aquaporin 2: From its discovery to molecular structure and medical implications

(2012) Sei Sasaki   MOLECULAR ASPECTS OF MEDICINE

Congenital nephrogenic diabetes insipidus: the current state of affairs

(2012) Daniel Wesche et al.   PEDIATRIC NEPHROLOGY

Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-Based Compound

(2012) Ana Paula Martins et al.   PLoS One

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

(2012) B. J. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Disease Amelioration With Tocilizumab in a Treatment-Resistant Patient With Neuromyelitis Optica

(2012) Bernd C. Kieseier et al.   JAMA Neurology

Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica

(2011) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Functional Characterization of Three Aquaglyceroporins from Trypanosoma brucei in Osmoregulation and Glycerol Transport

(2011) Björn Bassarak et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Water flux through human aquaporin 1: inhibition by intracellular furosemide and maximal response with high osmotic gradients

(2011) Marcelo Ozu et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Defective macrophage function in aquaporin-3 deficiency

(2011) Na Zhu et al.   FASEB JOURNAL

Hyperosmotic Stress Induces Aquaporin-dependent Cell Shrinkage, Polyphosphate Synthesis, Amino Acid Accumulation, and Global Gene Expression Changes inTrypanosoma cruzi

(2011) Zhu-Hong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice

(2011) Sabina Jelen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light inactivation of water transport and protein–protein interactions of aquaporin–Killer Red chimeras

(2011) Florian Baumgart et al.   JOURNAL OF GENERAL PHYSIOLOGY

Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics

(2011) William Castro-Borges et al.   Journal of Proteomics

Aquaporin-5: A Marker Protein for Proliferation and Migration of Human Breast Cancer Cells

(2011) Hyun Jun Jung et al.   PLoS One

Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes

(2011) S. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus

(2011) E. T. B. Olesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica

(2011) Norio Chihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

Structural insights into eukaryotic aquaporin regulation

(2010) Susanna Törnroth-Horsefield et al.   FEBS LETTERS

AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands

(2010) R Gao et al.   GENE THERAPY

Aquaporin 0 enhances gap junction coupling via its cell adhesion function and interaction with connexin 50

(2010) J. Liu et al.   JOURNAL OF CELL SCIENCE

Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer

(2010) Ziqiang Zhang et al.   JOURNAL OF PATHOLOGY

Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole

(2010) Kildare Miranda et al.   MOLECULAR MICROBIOLOGY

Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage

(2010) M.J. Tait et al.   NEUROSCIENCE

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

(2010) E. W. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated Cell-Based Assay for Screening of Aquaporin Inhibitors

(2009) Maria Grazia Mola et al.   ANALYTICAL CHEMISTRY

Novel therapeutic targets inPlasmodium falciparum: aquaglyceroporins

(2009) Jürgen F Kun et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies

(2009) Grazia Paola Nicchia et al.   GLIA

Aquaporin-1 Tunes Pain Perception by Interaction with Nav1.8 Na+Channels in Dorsal Root Ganglion Neurons

(2009) Hua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging

(2009) J. M. Crane et al.   JOURNAL OF CELL SCIENCE

Inhibition of Aquaporin-1 and Aquaporin-4 Water Permeability by a Derivative of the Loop Diuretic Bumetanide Acting at an Internal Pore-Occluding Binding Site

(2009) E. Migliati et al.   MOLECULAR PHARMACOLOGY

Aquaglyceroporin 9 in brain pathologies

(2009) J. Badaut   NEUROSCIENCE

Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG

(2009) R. Musa-Aziz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

(2009) J. D. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Yeast Aquaporin at 1.15 Å Reveals a Novel Gating Mechanism

(2009) Gerhard Fischer et al.   PLOS BIOLOGY

Membrane tension regulates water transport in yeast

(2008) Graça Soveral et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Inhibition of Aquaporin 4 by antiepileptic drugs

(2008) Vincent J. Huber et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice

(2008) S. Saadoun et al.   BRAIN

Membrane proteins: molecular dynamics simulations

(2008) E LINDAHL et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A cautionary note on cosmetics containing ingredients that increase aquaporin-3 expression

(2008) A. S. Verkman   EXPERIMENTAL DERMATOLOGY

Congenital nephrogenic diabetes insipidus: what can we learn from mouse models?

(2008) Michelle Boone et al.   EXPERIMENTAL PHYSIOLOGY

Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation

(2008) Baoxue Yang et al.   FASEB JOURNAL

Aquaporins—new players in cancer biology

(2008) A. S. Verkman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Is TEA an inhibitor for human Aquaporin-1?

(2008) E. Matthias Müller et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY