Therapeutic targeting of chemoresistant and recurrent glioblastoma stem cells with a proapoptotic variant of oncolytic herpes simplex virus

The Impact of Macrophage- and Microglia-Secreted TNF  on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment

(2015) W. H. Meisen et al.   CLINICAL CANCER RESEARCH

How to train glioma cells to die: molecular challenges in cell death

(2015) Jeffrey Wojton et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment

(2015) Fares Nigim et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Encapsulated Stem Cells Loaded With Hyaluronidase-expressing Oncolytic Virus for Brain Tumor Therapy

(2015) Jordi Martinez-Quintanilla et al.   MOLECULAR THERAPY

Convection-enhanced delivery for the treatment of glioblastoma

(2015) M. A. Vogelbaum et al.   NEURO-ONCOLOGY

Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

(2015) Paul A. Clark et al.   NEOPLASIA

Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

(2015) Wei Zhang et al.   NEOPLASIA

Stem Cells Loaded With Multimechanistic Oncolytic Herpes Simplex Virus Variants for Brain Tumor Therapy

(2014) Matthias Duebgen et al.   JNCI-Journal of the National Cancer Institute

Targeted molecular therapies against epidermal growth factor receptor: Past experiences and challenges

(2014) D. A. Reardon et al.   NEURO-ONCOLOGY

Oncolytic herpes simplex virus-based strategies: toward a breakthrough in glioblastoma therapy

(2014) Jianfang Ning et al.   Frontiers in Microbiology

Expansion of CD133-positive glioma cells in recurrent de novo glioblastomas after radiotherapy and chemotherapy

(2013) Kaoru Tamura et al.   JOURNAL OF NEUROSURGERY

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

(2013) Roshan Mahabir et al.   NEURO-ONCOLOGY

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model

(2013) T. A. Cheema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling

(2013) Kareem N. Mohni et al.   PLoS Pathogens

Enhancing CHK1 inhibitor lethality in glioblastoma

(2012) Yong Tang et al.   CANCER BIOLOGY & THERAPY

Multimechanistic Tumor Targeted Oncolytic Virus Overcomes Resistance in Brain Tumors

(2012) Kaoru Tamura et al.   MOLECULAR THERAPY

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects

(2012) J. A. J. M. van de Water et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherapy in Killing Glioblastoma Stem Cells

(2011) Ryuichi Kanai et al.   JNCI-Journal of the National Cancer Institute

Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells

(2011) H. Wakimoto et al.   NEURO-ONCOLOGY

Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy

(2011) X. Gong et al.   NEUROLOGY

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme

(2011) H J Jun et al.   ONCOGENE

ATR and ATRIP Are Recruited to Herpes Simplex Virus Type 1 Replication Compartments Even though ATR Signaling Is Disabled

(2010) K. N. Mohni et al.   JOURNAL OF VIROLOGY

Sensitivity to temozolomide in brain tumor initiating cells

(2010) M. D. Blough et al.   NEURO-ONCOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Biology of glioma cancer stem cells

(2009) Deric M. Park et al.   MOLECULES AND CELLS

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy

(2009) L. S. Sasportas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells

(2008) Y. Dai et al.   BLOOD

Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma

(2008) D. Beier et al.   CANCER RESEARCH

Bimodal Viral Vectors and In Vivo Imaging Reveal the Fate of Human Neural Stem Cells in Experimental Glioma Model

(2008) K. Shah et al.   JOURNAL OF NEUROSCIENCE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Glioma Stem Cells: A Midterm Exam

(2008) Charles D. Stiles et al.   NEURON

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth

(2008) Han Li et al.   VIROLOGY