Endogenous lipid antigens for invariant natural killer T cells hold the reins in adipose tissue homeostasis

Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets

(2017) Eleanor Clancy-Thompson et al.   JOURNAL OF IMMUNOLOGY

Global Health Effects of Overweight and Obesity

(2017) Edward W. Gregg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children

(2017) Genoveva Keustermans et al.   PLoS One

Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs

(2017) Beatriz Dal Santo Francisco Bonamichi et al.   Diabetes & Metabolism Journal

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

(2016) Lydia Lynch et al.   Cell Metabolism

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

(2016) Byung-Cheol Lee et al.   Cell Metabolism

Adipose tissue in control of metabolism

(2016) Liping Luo et al.   JOURNAL OF ENDOCRINOLOGY

TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells

(2016) Joshua A Vieth et al.   NATURE IMMUNOLOGY

Innate-like functions of natural killer T cell subsets result from highly divergent gene programs

(2016) Isaac Engel et al.   NATURE IMMUNOLOGY

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Lipidomics for studying metabolism

(2016) Xianlin Han   Nature Reviews Endocrinology

The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells

(2016) Juan A. Torreno-Pina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Role of Epigenetics in Inflammation and Immunometabolism

(2016) Sukanya Raghuraman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adipocyte-specific CD1d-deficiency mitigates diet-induced obesity and insulin resistance in mice

(2016) Masashi Satoh et al.   Scientific Reports

CD1d-dependent endogenous and exogenous lipid antigen presentation

(2015) Rosanna M McEwen-Smith et al.   CURRENT OPINION IN IMMUNOLOGY

A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production

(2015) Alysia M. Birkholz et al.   JOURNAL OF IMMUNOLOGY

The complex immunological and inflammatory network of adipose tissue in obesity

(2015) Vasso Apostolopoulos et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Regulatory Role of Invariant NKT Cells in Tumor Immunity

(2015) Rosanna M. McEwen-Smith et al.   Cancer Immunology Research

Recognition of Microbial Glycolipids by Natural Killer T Cells

(2015) Dirk M. Zajonc et al.   Frontiers in Immunology

The Identification of the Endogenous Ligands of Natural Killer T Cells Reveals the Presence of Mammalian α-Linked Glycosylceramides

(2014) Lisa Kain et al.   IMMUNITY

Adipose invariant natural killer T cells

(2014) Lydia Lynch   IMMUNOLOGY

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

(2014) Un Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD1d-mediated Presentation of Endogenous Lipid Antigens by Adipocytes Requires Microsomal Triglyceride Transfer Protein

(2014) Maryam Rakhshandehroo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between the immune system and adipose tissue in obesity

(2014) Mark A Exley et al.   JOURNAL OF ENDOCRINOLOGY

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

Mice Lacking Natural Killer T Cells Are More Susceptible to Metabolic Alterations following High Fat Diet Feeding

(2014) Brittany V. Martin-Murphy et al.   PLoS One

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

(2014) Patrick J. Brennan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of Invariant Natural Killer T Cells Affects Lipid Metabolism in Adipose Tissue of Diet-Induced Obese Mice

(2013) Daniela Strodthoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

(2013) Tuo Deng et al.   Cell Metabolism

Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease

(2013) M. Rakhshandehroo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glycosphingolipids: synthesis and functions

(2013) Giovanni D'Angelo et al.   FEBS Journal

CD40L Stimulates the Crosstalk Between Adipocytes and Inflammatory Cells

(2013) A. Chatzigeorgiou et al.   HORMONE AND METABOLIC RESEARCH

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

(2013) Koen Venken et al.   JOURNAL OF HEPATOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

(2013) R. Bedel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic adipose tissue inflammation: all immune cells on the stage

(2013) Gökhan Cildir et al.   TRENDS IN MOLECULAR MEDICINE

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity

(2012) Yewei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4

(2012) Yewei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural killer T cells in adipose tissue prevent insulin resistance

(2012) Henk S. Schipper et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells

(2012) J. Y. Huh et al.   MOLECULAR AND CELLULAR BIOLOGY

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

(2012) Nadia R Cohen et al.   NATURE IMMUNOLOGY

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Type II NKT Cells Stimulate Diet-Induced Obesity by Mediating Adipose Tissue Inflammation, Steatohepatitis and Insulin Resistance

(2012) Masashi Satoh et al.   PLoS One

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

(2012) L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose tissue-resident immune cells: key players in immunometabolism

(2012) Henk S. Schipper et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells

(2011) Fenna C.M. Sillé et al.   IMMUNOLOGY LETTERS

Requirement for Invariant Chain in Macrophages for Mycobacterium tuberculosis Replication and CD1d Antigen Presentation

(2011) Fenna C. M. Sillé et al.   INFECTION AND IMMUNITY

Induction of Lectin-like Transcript 1 (LLT1) Protein Cell Surface Expression by Pathogens and Interferon-γ Contributes to Modulate Immune Responses

(2011) Claire Germain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection

(2011) Manfred Brigl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Structural Basis for the Recognition of  -Linked Glycolipid Antigens by Invariant NKT Cells

(2011) E. D. Yu et al.   JOURNAL OF IMMUNOLOGY

Dynamics of human adipose lipid turnover in health and metabolic disease

(2011) Peter Arner et al.   NATURE

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

(2011) Patrick J Brennan et al.   NATURE IMMUNOLOGY

Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria

(2011) Yuki Kinjo et al.   NATURE IMMUNOLOGY

Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity

(2011) Benjamin S. Mantell et al.   PLoS One

Impact of CD1d Deficiency on Metabolism

(2011) Maya E. Kotas et al.   PLoS One

Role of NKT cells in allergic asthma

(2010) Chiaki Iwamura et al.   CURRENT OPINION IN IMMUNOLOGY

Short-Term Overfeeding May Induce Peripheral Insulin Resistance Without Altering Subcutaneous Adipose Tissue Macrophages in Humans

(2010) C. S. Tam et al.   DIABETES

Regulation of CD1 Antigen-presenting Complex Stability

(2010) Artur N. Odyniec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

(2010) N. Ouchi et al.   SCIENCE

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Invariant NKT cells and CD1d+cells amass in human omentum and are depleted in patients with cancer and obesity

(2009) Lydia Lynch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct Requirements for CD1d Intracellular Transport for Development of V 14 iNKT Cells

(2009) F. C. M. Sille et al.   JOURNAL OF IMMUNOLOGY

Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation

(2009) Marco van Eijk et al.   PLoS One

Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen  GalCer

(2009) L. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen recognition by CD1d-restricted NKT T cell receptors

(2009) Dale I. Godfrey et al.   SEMINARS IN IMMUNOLOGY

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

(2008) Jennifer L Matsuda et al.   CURRENT OPINION IN IMMUNOLOGY

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY