Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets

The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs

(2017) Anna S. Tocheva et al.   JOURNAL OF IMMUNOLOGY

Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs

(2016) Kenji Chamoto et al.   JOURNAL OF IMMUNOLOGY

Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming

(2016) Mayra Cruz Tleugabulova et al.   JOURNAL OF IMMUNOLOGY

TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells

(2016) Ageliki Tsagaratou et al.   NATURE IMMUNOLOGY

Innate-like functions of natural killer T cell subsets result from highly divergent gene programs

(2016) Isaac Engel et al.   NATURE IMMUNOLOGY

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors

(2016) Tingxi Guo et al.   PLoS One

Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets

(2016) Hristo Georgiev et al.   Nature Communications

Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response

(2015) You Jeong Lee et al.   IMMUNITY

The Alpha and Omega of Galactosylceramides in T Cell Immune Function

(2015) Alysia M. Birkholz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development

(2015) Marta Monteiro et al.   JOURNAL OF IMMUNOLOGY

Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity

(2015) Garth Cameron et al.   JOURNAL OF IMMUNOLOGY

Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis

(2015) Salah Mansour et al.   JOURNAL OF IMMUNOLOGY

The Extended Family of CD1d-Restricted NKT Cells: Sifting through a Mixed Bag of TCRs, Antigens, and Functions

(2015) Elodie Macho-Fernandez et al.   Frontiers in Immunology

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

IL-10–producing NKT10 cells are a distinct regulatory invariant NKT cell subset

(2014) Duygu Sag et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired SLAM-SLAM Homotypic Interaction between Invariant NKT Cells and Dendritic Cells Affects Differentiation of IL-4/IL-10-Secreting NKT2 Cells in Nonobese Diabetic Mice

(2014) D. V. Baev et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Discrete Functions of mTOR Signaling in Invariant NKT Cell Development and NKT17 Fate Decision

(2014) Jun Wei et al.   JOURNAL OF IMMUNOLOGY

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue

(2014) Lydia Lynch et al.   NATURE IMMUNOLOGY

iNKT Cell Production of GM-CSF Controls Mycobacterium tuberculosis

(2014) Alissa C. Rothchild et al.   PLoS Pathogens

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

(2013) Stephanie K. Dougan et al.   NATURE

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells

(2013) You Jeong Lee et al.   NATURE IMMUNOLOGY

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

(2013) S. K. Dougan et al.   Cancer Immunology Research

The transcription factor Th-POK negatively regulates Th17 differentiation in V 14i NKT cells

(2012) I. Engel et al.   BLOOD

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

(2012) Nadia R Cohen et al.   NATURE IMMUNOLOGY

IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells

(2012) S. K. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Development and Function of Invariant Natural Killer T Cells Producing TH2- and TH17-Cytokines

(2012) Hiroshi Watarai et al.   PLOS BIOLOGY

A Molecular Basis for NKT Cell Recognition of CD1d-Self-Antigen

(2011) Thierry Mallevaey et al.   IMMUNITY

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

(2011) Kwok S. Wun et al.   IMMUNITY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Structural Basis for the Recognition of  -Linked Glycolipid Antigens by Invariant NKT Cells

(2011) E. D. Yu et al.   JOURNAL OF IMMUNOLOGY

NKT Cells Inhibit Antigen-Specific Effector CD8 T Cell Induction to Skin Viral Proteins

(2011) S. R. Mattarollo et al.   JOURNAL OF IMMUNOLOGY

NKT TCR Recognition of CD1d- -C-Galactosylceramide

(2011) O. Patel et al.   JOURNAL OF IMMUNOLOGY

Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

(2011) Daniel G Pellicci et al.   NATURE IMMUNOLOGY

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

(2011) Patrick J Brennan et al.   NATURE IMMUNOLOGY

Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner

(2011) Irah L King et al.   NATURE IMMUNOLOGY

Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy

(2011) T.-N. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique Interplay between Sugar and Lipid in Determining the Antigenic Potency of Bacterial Antigens for NKT Cells

(2011) Enrico Girardi et al.   PLOS BIOLOGY

The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode

(2010) Yali Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma gondii Obtained via SCNT

(2010) O. Kirak et al.   SCIENCE

Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 and Vβ7 Semi-invariant NKT T Cell Receptors

(2009) Daniel G. Pellicci et al.   IMMUNITY

Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor  t+ and Respond Preferentially under Inflammatory Conditions

(2009) J.-M. Doisne et al.   JOURNAL OF IMMUNOLOGY

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

(2009) Jhoanne L Bautista et al.   NATURE IMMUNOLOGY

Critical role of ROR- t in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation

(2008) M.-L. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA